Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Freeze dried isatis root powder for injection and its prepn

A technology of freeze-dried powder injection and Banlangen, which is applied in the field of preparation of the Banlangen freeze-dried powder injection, can solve the problem of high stability and bioavailability, and achieve good therapeutic effect, high bioavailability, and definite effect

Inactive Publication Date: 2003-11-05
吴梅春
View PDF0 Cites 7 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the clinically used injection is a 2ml intramuscular injection, and there is no freeze-dried powder injection with good stability, high bioavailability, and available for intravenous injection, which limits the further clinical application of Radix isatidis

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Take 500g of Radix Radix, cut into small pieces, add 12 times the amount of water to decoct and boil, then soak at 90°C for 1 hour, then soak the dregs once more in the same way, combine the soaking liquid, filter, and concentrate the filtrate under reduced pressure to a relative density of 1.05 (60 ℃), add ethanol to make the alcohol content to 65%, stir evenly, let it stand, filter, and recover the ethanol to 450ml from the filtrate under reduced pressure, refrigerate for 28 hours, filter, adjust the pH value of the filtrate to 8.5 with ammonia test solution, and stir evenly , refrigerated for 48 hours, filtered, heated to remove ammonia, let cool, ultrafiltered, added water for injection to the filtrate to 900ml, refrigerated, filtered, adjusted the pH value of the filtrate to 7.5 with 10% sodium carbonate solution, stood still, filtered, Add 50 g of mannitol to the filtrate and add water for injection to 1000 ml, filter with 0.65 μm and 0.22 μm microporous membranes ...

Embodiment 2

[0019] Take 520g of Radix Radix, cut into small pieces, add 10 times the amount of water to decoct and boil, then soak at 80°C for 1 hour, then soak the dregs twice in the same way, combine the soaking liquid, filter, and concentrate the filtrate under reduced pressure to a relative density of 1.08 (60 ℃), add ethanol to make the alcohol content to 75%, stir evenly, let it stand, filter, and recover the ethanol to 490ml from the filtrate under reduced pressure, refrigerate for 32 hours, filter, adjust the pH value of the filtrate to 8.0 with ammonia test solution, and stir evenly , refrigerated for 48 hours, filtered, heated to remove ammonia, let cool, ultrafiltered, added water for injection to the filtrate to 900ml, refrigerated, filtered, adjusted the pH value of the filtrate to 7.0 with 10% sodium carbonate solution, stood still, filtered, Add 40 g of mannitol and 15 g of glucose to the filtrate and add water for injection to the specified amount, filter through 0.65 μm an...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention discloses one kind of freeze dried isatis root powder for injection, which is prepared with isatis root as main material and through extraction, refining, blending with proper amount of medicinal supplementary material and freeze drying. The present invention has high stability, long effective period, obvious antiseptic, antiviral, heat-clearing away and immunity-strengthening functions, good safety and no negative effect.it has excellent treating effect on influenza, parotitis, hepatitis, encephalitis B, upper respiratory tract infection and other diseases.

Description

Technical field [0001] The invention relates to a Radix Radix freeze-dried powder injection, and also relates to a preparation method of the Radix Radix freeze-dried powder injection. Background technique [0002] Isatis root is a traditional Chinese medicine. It has been recorded in successive dynasties of herbal medicines. It was first recorded in "Shen Nong's Materia Medica". It is the dried root of Isatis indigicafort, a cruciferous plant. It is widely used in the treatment of viral and bacterial diseases such as hepatitis, mumps, influenza, erysipelas, meningitis and tonsillitis. At present, the clinically used injection is a 2ml intramuscular injection, and there is no freeze-dried powder injection with good stability, high bioavailability, and available for intravenous injection, which limits the further clinical application of Radix isatidis. Contents of the invention [0003] The object of the present invention is to provide a isatidis freeze-dried powder injecti...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/19A61P1/16A61P31/04A61P31/12
Inventor 吴梅春
Owner 吴梅春
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com