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Absorbable active tissue matter for repairing hard tissue and its prepn

A hard tissue and composition technology, applied in the field of absorbable active compositions and their preparation, can solve problems such as unfavorable bone synthesis, and achieve the effects of improving biodegradation and absorption function, simple equipment, and improving biocompatibility

Inactive Publication Date: 2003-03-19
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no detailed description in the literature that this material has a significant effect of inducing bone growth, which is not conducive to bone synthesis and delays bone healing

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Preparation of hard tissue repair materials: absorbable synthetic polymer materials can be poly-L-lactic acid, poly-(D, L)-lactic acid, polyglycolic acid, polycaprolactone, polybutyrolactone, polyvalerolactone, One of polyester dioxane, polyanhydride, or a copolymer of at least two of the following monomers: L-lactic acid, (D, L)-lactic acid, glycolic acid, caprolactone, butyrolactone, Valerolactone, or their blends. For example, 0.6 g of poly-L-lactic acid is dissolved in chloroform, 0.4 g of unsintered hydroxyapatite with a particle size of about 1 micron is dispersed in chloroform, and the two are mixed, and 1 mg of human gene recombinant bone without separation and purification The forming protein (BMP) is dispersed in chloroform and mixed with the former, and the above-mentioned part of the mixed liquid is slowly injected into cold ethanol containing an appropriate amount of gentamicin, and the composite material is precipitated, vacuum-dried to remove the solvent,...

Embodiment 2

[0037] Preparation of hard tissue repair materials: Bone growth factor can be heterologous bone morphogenic protein or human recombinant bone morphogenic protein, which can be heterogeneous bone morphogenic protein without separation and purification, human recombinant bone morphogenic protein (BMP), BMP-1, BMP-2, BMP-3, BMP-4, BMP-5, BMP-6, BMP-7, BMP-8, growth / differentiation factor GDF-5, GD-6, GDF-7 or two or more thereof mixture. For example, recombinant bone morphogenetic protein-2 (BMP-2) using the isolated human gene. Dissolve 0.85 g of poly-L-lactic acid with a weight average molecular weight of 150,000 in dioxane, 0.15 g of unsintered hydroxyapatite with a particle size of about 1 micron and 1 mg of BMP-2 in dioxane , mix the two, and add an appropriate amount of gentamicin, inject the above mixture into the cavity—a cylindrical mold with a diameter of 15 mm and a height of 20 mm, freeze-dry at -70°C, and sterilize with ethylene oxide to obtain Porous hard tissue r...

Embodiment 3

[0039] Preparation of hard tissue repair materials: unsintered calcium phosphate salt can use low-temperature synthesized hydroxyapatite (Ca 10 (PO 4 ) 6 (OH) 2 ), tricalcium phosphate (Ca 3 (PO 4 ) 2 ), calcium pyrophosphate (Ca 2 P 2 o 7 ), calcium hydrogen phosphate (CaHPO 4 ), calcium hydrogen phosphate dihydrate (CaHPO 4 .2H 2 O) one or a mixture of two or more calcium phosphate salts. For example, using unsintered tricalcium phosphate (Ca 3 (PO 4 ) 2 ). Dissolve 0.7 gram of poly L-lactic acid with a weight average molecular weight of 150,000 in dioxane, 0.2 gram of chitosan short fibers with a length of about 3 mm and 0.2 gram of unsintered chitosan fibers with a particle size of about 1 micron Tricalcium phosphate and 1 mg of bone morphogenic protein were dispersed in dioxane, and the two were mixed evenly. Part of the above mixture was injected into the cavity—a cylindrical mold with a diameter of 15 mm and a height of 20 mm, freeze-dried at -70°C, and ...

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PUM

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Abstract

The present invention relates to surgical material. The material includes biologically absorbable polymer 10-90 wt%, un-sintered calcium phosphate salt 5-80 wt%, and bone growth factor less than 10 wt%. The biologically absorbable polymer includes polyester, chitosan, chondroitin sulfate, collagen, alginate, etc.; and the calcium phosphate salt is un-sintered hydroxyapatite or tricalcium phosphate of granularity less than 100 microns. The hard tissue repairing material is prepared through mixing biologically absorbably polymer, un-sintered calcium phosphate salt and bone growth factor dispersed in solvent, molding, freeze drying to eliminate solvent and obtain the composition. The composition has the function of promoting bond healing and excellent biocompatibility.

Description

1. Technical field: [0001] The invention relates to an absorbable active composition for hard tissue repair and a preparation method thereof, belonging to the technical field of preparation of materials for medical surgery. 2. Background technology: [0002] Hard tissues such as human bones and teeth are damaged due to disease or trauma, and artificial materials are required for repair or correction. Such repair materials include metals, inorganic materials, polymer materials, etc. [0003] Bone repair materials made of stainless steel or titanium alloy have high strength, low cost, and high frequency of use, but stress shielding may occur, which may lead to bone resorption, delay bone healing, and poor tissue compatibility. lead to inflammatory reactions, etc. [0004] Hydroxyapatite and tricalcium phosphate are commonly used bioceramics. Calcium phosphate bone cement is also commonly used in hard tissue repair. It has good biocompatibility. Hydroxyapatite can also induce...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/00A61L31/12
Inventor 李新松浦跃朴哈涌泉邹俊章庆国
Owner SOUTHEAST UNIV
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