Calcium metasilicates and methods for making the same

A technology of calcium metasilicate and calcium source, applied in the directions of botanical equipment and methods, application, silicate, etc., can solve the problems of low effective treatment dose, slowness and unevenness of antibiotics

Inactive Publication Date: 2007-05-09
EVONIK OPERATIONS GMBH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Unfortunately, most tablets do not dissolve immediately in the mouth, but disintegrate in a slow and uneven manner, so that if the tablet is not swallowed, the dose released into the bloodstream is significantly lower than Effective therapeutic dose
This problem is particularly acute when drug tablets are administered to treat bacterial diseases, as the patient refuses to swallow the tablet, resulting in less than therapeutically effective amounts of antibiotic being released into the bloodstream, causing the bacteria to develop resistance to the antibiotic

Method used

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  • Calcium metasilicates and methods for making the same
  • Calcium metasilicates and methods for making the same
  • Calcium metasilicates and methods for making the same

Examples

Experimental program
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Effect test

Embodiment 1

[0069] Calcium metasilicate was prepared by conventional methods of the prior art by combining 10 g of Hubersorb(R) 250 amorphous calcium silicate (available from J.M. Huber Corporation in Havre de Grace, Maryland) with 5.4 g in a V-shaped mill. Dry calcium hydroxide powder (Chemstone Corporation, Strasburg, VA) was mixed for 15 minutes. The mixture was then dehydrated (or "calcined") in an autoclave at 900°C for 4 hours. The final dehydration product was recovered, and its composition was determined to be calcium metasilicate by powder X-ray diffraction, mainly in the form of wollastonite, with a small amount of crystalline silica (cristobalite polymorph) simultaneously (see Table V below) . The properties of the calcium metasilicate of Example 1 are shown in Table IV below.

Embodiment 2

[0071] In the first step of this example, sulfuric acid is added to a dilute waterglass solution in a well-stirred vessel to affect the precipitation of amorphous hydrated silica to produce a calcium metasilicate suitable for use in the preparation of calcium metasilicate. of amorphous silica. Specifically, under stirring conditions at 95°C, 500 gallons of water glass solution containing 13% sodium silicate solids (SiO 2 / Na 2 A total of 278 gallons of 11.5% sulfuric acid was added at a rate of 4.7 gpm (gallons per minute) to a molar ratio of O of 3.3). Sulfuric acid was added continuously until the pH reached 5.5 and the reaction mixture was digested for 1 hour. The resulting suspension of silica particles is recovered by filtration, washed and dried to form a finely dispersed reactive silica powder. Then, in a stirring vessel, 90 kg of the aqueous solution (solid content 16%) of the reactive silica powder obtained above was mixed with 105 kg lime slurry (solid content 18%...

Embodiment 3

[0078] Prepare calcium metasilicate according to the method of the present invention, the method is that the pure Ca(OH) of 10.5g drying 2(from Chemstone Corporation) was mixed with 56.25 g of the reactive silica aqueous slurry (16% solids) prepared in Example 2 to obtain a homogeneous mixture. The mixture was then filtered to recover the solids, which were then dried at 105°C for 16 hours and then dehydrated (calcined) in a 900°C kiln for 1 hour. Characterization of the recovered product by X-ray powder diffraction revealed that it was wollastonite type 2M, which contained no trace of crystalline silica. The properties of the calcium metasilicate of Example 3 are shown in Table V below.

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Abstract

The invention discloses a calcium metasilicate, the aspect ratio (the average diameter of the major axis / the average diameter of the minor axis) is about 1:1 to about 2.5:1, and the oil absorption rate is about 20ml / 100g to about 220ml / 100g. The calcium metasilicate of the present invention can be used as an additive for medicines, food, agricultural products, personal care products, household care products and similar products, when the products in solid form (such as tablets) contain this calcium metasilicate, and the formed Tablet disintegration rates are significantly increased when the product is exposed to a substantially aqueous environment such as mammalian saliva or mucus.

Description

technical field [0001] The present invention relates to calcium metasilicate and its preparation method and application. Background technique [0002] Many consumer products like healthcare and personal care products are produced and packaged in solid pressed form. The solid pressed product form has many advantages over other product forms, such as easier production, good transport durability, and ease of storage for retailers and consumers alike. Oral over-the-counter and nutritional supplements are particularly well-suited for solid tablet form, as virtually any active drug formulation can be granulated and powdered without compromising potency. In addition, after swallowing, the tablet disintegrates rapidly in the acidic environment of the stomach, and the active agent in the tablet is rapidly digested and absorbed into the blood. [0003] However, in some cases it is advantageous for the tablet to disintegrate in the mouth so that the active ingredient of the drug can ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C01B33/24A61K9/14A61K9/16A61K8/25A23P1/00A61K47/02C01B33/26A01N25/08A23L1/00A23L29/294A61K9/00A61K9/20A61K9/22A61K47/04A61K47/12A61K47/26A61K47/32A61K47/36A61K47/38A61Q5/02A61Q19/00A61Q19/10C05D3/04
CPCC05D3/04C01B33/24A61Q5/02A23L1/0041A61K8/25A61K9/2009A61K9/0056A61Q19/10A23L1/059A23P10/47A23L29/294C01B33/26A61K9/14A61K9/20
Inventor 迈克尔·C·威辛阿姆唐纳德·P·科尔尼爱德华·T·扬努
Owner EVONIK OPERATIONS GMBH
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