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Medicine of polysaccharide sulfate amino acid salt, its preparation and application

A technology of polysaccharide sulfate and amino acid salt, which is applied in the preparation of drugs for the treatment of chronic nephritis and renal failure. In the field of polysaccharide sulfate amino acid salt medicine and preparation, it can solve the problems of low solubility and poor taste, and achieve simple production process , low cost, and the effect of eliminating adverse effects

Inactive Publication Date: 2006-11-22
NANJING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these patented products all have the disadvantages of poor mouthfeel, nausea, and low solubility of certain amino acids or α-keto acids and α-hydroxy acid analogues.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Example 1 Composition of Polysaccharide Sulfate Amino Acid Salt Drugs

[0038] (1) Polysaccharide sulfate arginine salt: L-arginine accounts for 38.4% by weight of the finished product, and polysaccharide sulfate accounts for 61.6%. Among them, the molecular weight distribution range of the polysaccharide sulfate ester is 6,000-200,000, and the sulfate content is 48.6%.

[0039] (2) Seaweed polysaccharide sulfate mixed amino acid salt: seaweed polysaccharide sulfate accounts for 47.6% of the product weight, and mixed amino acid is 52.4%. Among them, the sulfate content of seaweed polysaccharide sulfate ester is 45.0%, and the molecular weight distribution range is 5,000-150,000; among the mixed amino acids, L-ornithine accounts for 23.8% of the weight ratio of seaweed polysaccharide sulfate ester mixed amino acid salt, and L-leucine Acid, L-isoleucine and L-valine each accounted for 9.5%.

[0040] (3) Chondroitin sulfate mixed amino acid salt: chondroitin sulfate acco...

Embodiment 2

[0041] The chemical synthesis preparation of embodiment 2 pachyrhin polysaccharide sulfate arginine salt, its preparation steps are as follows:

[0042] 1. Extraction of Poria cocos polysaccharide

[0043] (1) 100g Poria cocos dry powder is placed in the 1mol / LNaOH dilute alkali solution of 5 times amount and soaks at room temperature for 4 hours;

[0044] (2) The viscous liquid is separated by suction filtration, and the residue is extracted once again with 3 times the amount of lye, and the extracts are combined twice;

[0045] (3) The extract was neutralized to pH 6 with 10% acetic acid solution, added 3 times the amount of 95% ethanol, left at 4°C overnight, centrifuged to separate the precipitate, and dialyzed against running water for two days;

[0046] (4) After washing with distilled water and absolute ethanol in sequence, vacuum drying was performed to obtain 63.7 g of white powder.

[0047] 2, the preparation of pachyphyllan sulfate ester

[0048] (1) Add 240ml of...

Embodiment 3

[0062] The chemical synthesis preparation of embodiment 3 pachyrhin polysaccharide sulfate ester ornithine

[0063] 1, the preparation process of polysaccharide polysaccharide and polysaccharide sulfate is with embodiment 2;

[0064] 2, the acidification process of 100g pachymansan sulfate ester to remove sodium ion is the same as embodiment 2;

[0065] 3. Make 50g of commercially available L-ornithine into a 20% solution;

[0066] 4. Slowly stir and add L-ornithine solution into the acidic polysaccharide sulfate solution, monitor the pH value of the solution during the salt formation reaction, stop adding L-ornithine solution when the pH reaches 6.5, the actual The dosage is 44g;

[0067] 5. After activated carbon decolorization, concentration and drying, light yellow powder was obtained, weighing 124g;

[0068] 6. L-ornithine accounted for 35.5% by weight of the finished product, and polysaccharide sulfate accounted for 64.5%.

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Abstract

The invention discloses a polysaccharide sulfate amino acid salt drug and a preparation method thereof. The drug is a complex formed by polysaccharide sulfate polyanion carrier and amino acid salt formation, wherein the weight ratio of polysaccharide sulfate to the complex is 10 %-95%, amino acid accounts for 5%-90%. The preparation method of the drug comprises the following steps: (1) extraction of polysaccharide; (2) preparation of polysaccharide sulfate; (3) preparation of polysaccharide sulfate amino acid salt. Because the drug combines polysaccharide sulfate with amino acid to form a salt, it helps to remove metal ions produced during the preparation of polysaccharide sulfate, and integrates their immunomodulatory activity and pharmacological activity for treating chronic nephritis and renal failure, thereby producing a positive effect. To the synergistic effect, the protective effect of polysaccharide sulfate amino acid salt on renal function of patients with kidney disease is stronger than that of polysaccharide sulfate and natural amino acid alone. This type of medicine has good water solubility, remarkable curative effect, low toxicity and no side effect, and is a good medicine for treating chronic nephritis and renal failure diseases.

Description

1. Technical field [0001] The invention relates to the technical field of biochemical pharmacy, in particular to a polysaccharide sulfate amino acid salt drug, a preparation method and its application in the preparation of drugs for treating chronic nephritis and renal failure. 2. Background technology [0002] Renal failure is a syndrome involving water and electrolyte disorders, acid-base balance disorders, and multiple organ dysfunctions caused by renal parenchymal damage caused by various reasons. It is difficult to treat and the medical expenses are expensive. According to relevant statistics, there are about 30 million kidney patients in my country, and the incidence of chronic renal failure is about 5 / 10,000 of the total population, and tens of thousands of them die from uremia every year. In recent decades, the advent and continuous improvement of blood purification technology, as well as the development of nutritional therapy, antibiotics and other technologies have...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/737A61K9/20A61K9/48A61K9/08A61P13/12A61K31/195
Inventor 焦庆才陈群李绪亮刘茜
Owner NANJING UNIV
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