Process for preparing simvastation drip pill
A technology for simvastatin and dripping pills, which is applied in the field of preparation of simvastatin dripping pills, can solve the problems of expensive imported drugs, monotonous dosage forms, restrictions on the use of drugs, etc., and achieves advantages of labor protection, easy operation, and long treatment cycle. Effect
Inactive Publication Date: 2004-09-01
AOLING BODA MEDICINE SCI & TECH DEV BEIJING
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Problems solved by technology
Due to the high price of imported drugs, the use of such drugs is restricted
At present, my country has approved the production of raw materials, tablets, and capsules. Simvastatin is a bulk product, and the dosage form is monotonous.
Method used
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[0031] Example
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Abstract
The present invention relates to medicine preparation technology. The Simvastatin drip pill is prepared with Simvastatin as material medicine as wells as polyglycol-6000, polyglycol-4000, teriary butyl-4-hydroxyl methyl phenoxide, Tween-80 and other supplementary material. The preparation process includes crushing and grinding of Simvastatin, mixing polyglycol-6000 and polyglycol-4000 and heating to melt, cooling to 72-78 deg.c, mixing fine Simvastatin powder with other supplementary material via stirring, dripping and air drying. The Simvastatin drip pill has high fast effect, biological utilization and less side effect.
Description
technical field [0001] The invention relates to a preparation method of simvastatin dripping pills, belonging to the technical field of medicine preparation. Background technique [0002] Simvastatin is a synthetic drug of the fermentation product of oxytetracycline. It is a blood lipid regulating drug for the treatment of hypercholesterolemia and prevention of atherosclerosis. It is currently one of the most effective lipid-lowering drugs clinically. Merck & Co., Ltd. of the United States obtained the patent right for this compound in 1981. First launched in Sweden in 1988. Listed in the United States in 1989. Hyperlipidemia often leads to many cardiovascular and cerebrovascular diseases such as atherosclerosis and coronary heart disease, and is often accompanied by diabetes, fatty liver, and nephrotic syndrome. Cardiovascular and cerebrovascular diseases seriously endanger human health and become the main cause of death among Chinese residents. The main function of sim...
Claims
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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K31/351A61P3/06A61P9/10
Inventor 许群
Owner AOLING BODA MEDICINE SCI & TECH DEV BEIJING
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