Kushenin tablet and preparation method thereof

A technology of matrine and ginseng tablets, which is applied in the direction of medical formulas, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., which can solve incomplete release, easy to produce sticky punches, and unstable drug release and other problems, to achieve the effects of stable drug release, qualified content uniformity, and suitable for commercial scale production

Active Publication Date: 2022-03-18
广东逸舒制药股份有限公司 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] At present, in order to overcome the shortcomings of matrine’s unstable drug release, most of the existing technologies are based on the preparation of sustained-release preparations, but such sustained-release preparations have high technical requirements, and because matrine has strong hygroscopicity and is easy to soften, During the long-term preparation process, it is easy to produce sticking and punching, and there is a problem of content uniformity between the slow-release material and matrine, which can easily lead to rapid early release and incomplete subsequent release.

Method used

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  • Kushenin tablet and preparation method thereof
  • Kushenin tablet and preparation method thereof
  • Kushenin tablet and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0031] The preparation of embodiment 1 matrine tablet

[0032] The prescription composition of 1000 described matrine tablets

[0033] name Dosage (g) Matrine (D90=120-130μm) 200.00 Hydroxypropylmethylcellulose 12.00 Dextran 30.00 anhydrous lactose 75.00 Micropowder silica gel 6.00 Sodium stearyl fumarate 3.00 Croscarmellose Sodium 18.00

[0034] Preparation:

[0035] 1) Grinding matrine to a particle size D90 of 120-130 μm to obtain matrine powder;

[0036] 2) Separately pulverize hydroxypropyl methylcellulose, dextran, anhydrous lactose, croscarmellose sodium, micropowder silica gel, and sodium stearyl fumarate, pass through a 100-150 mesh sieve, and set aside;

[0037] 3) Add the sieved micro-powder silica gel to the matrine powder obtained in step 1), and stir at a speed of 300-500r / min for 10-15min to obtain a matrine dispersion;

[0038] 4) Add sieved hydroxypropyl methylcellulose and dextran to the matrine disper...

Embodiment 2

[0040] The preparation of embodiment 2 matrine tablets

[0041] The prescription composition of 1000 described matrine tablets

[0042]

[0043]

[0044] The preparation method is as in Example 1.

Embodiment 3

[0045] The preparation of embodiment 3 Kushensu Tablets The prescription composition of 1000 Kushensu Tablets

[0046] name Dosage (g) Matrine (D90=110-120μm) 200.00 Hydroxyethyl cellulose 18.00 Dextran 36.00 Calcium Dihydrogen Phosphate 100.00 Micropowder silica gel 16.00 Magnesium stearate 4.00 Crospovidone 30.00

[0047] The preparation method is as in Example 1.

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Abstract

The present invention discloses a kushenin tablet and a preparation method thereof, the kushenin tablet comprises kushenin, a sustained-release material, glucan, a filler, a flow aid, a lubricant, a disintegrating agent and pharmaceutically acceptable auxiliary materials, the particle size D90 of the kushenin is more than or equal to 100 [mu] m and less than or equal to 150 [mu] m, and the mass ratio of the kushenin to the sustained-release material to the glucan is 1: 0.05-0.1: 0.1-0.2. The mass ratio of the flow aid to the lubricant is (1-4): 1. The product disclosed by the invention has the advantages of stable and long-acting drug release, no sticking, tablet cracking and other phenomena in the tabletting process, qualified content uniformity, qualified and stable product quality, simple process operation and high application value, and is suitable for commercial large-scale production.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to matrine tablets and a preparation method thereof. Background technique [0002] Matrine (Oxymatrine, Oxymatrine) is an alkaloid extracted from the traditional Chinese medicine Sophora flavescens, containing more than 98% of oxymatrine and a very small amount of oxymatrine, the chemical formula of oxymatrine for C 15 h 24 N 2 o 2 , with a molecular weight of 264, colorless crystals, easily soluble in water, and the structural formula of matrine is: [0003] [0004] Studies have shown that matrine has anti-tumor, antibacterial, anti-virus, improving liver function and preventing liver fibrosis, reducing transaminase, and improving the body's immunity. After taking matrine, the hepatitis B virus in infected cells will replicate in the body Level (quantitative detection of genes), alanine aminotransferase and bilirubin in chronic hepatitis B patients re...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/4375A61K47/38A61K47/36A61K47/04A61K47/12A61K47/02A61P1/16A61P31/04A61P31/12A61P31/20A61P35/00A61P37/04A61P43/00
CPCA61K31/4375A61K9/2009A61K9/2013A61K9/2054A61K9/205A61P35/00A61P31/04A61P31/12A61P1/16A61P43/00A61P37/04A61P31/20
Inventor 邓军王如山史敏李勇袁波刘玲
Owner 广东逸舒制药股份有限公司
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