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Lignin-based pH-responsive magnetic nano-drug carrier as well as preparation method and application thereof

A magnetic nano, lignin-based technology, applied in drug combinations, pharmaceutical formulations, anti-tumor drugs, etc., can solve the problems of low active targeting, strong toxic and side effects, low drug loading rate, etc., and achieve low price and low toxic and side effects Effect of low and good biocompatibility

Active Publication Date: 2022-03-15
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the problems of low active targeting of existing drug carriers, low drug loading rate, strong toxic and side effects, etc., the primary purpose of the present invention is to provide a method for preparing a lignin-based pH-responsive magnetic nano-antibody carrier

Method used

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  • Lignin-based pH-responsive magnetic nano-drug carrier as well as preparation method and application thereof
  • Lignin-based pH-responsive magnetic nano-drug carrier as well as preparation method and application thereof
  • Lignin-based pH-responsive magnetic nano-drug carrier as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Example 1Fe 3 o 4 Preparation of / ALS Composite Drug Carrier Nanoparticles

[0059] Water phase preparation: weigh 0.02g of nano-Fe 3 o 4 Particles (20nm) and 0.04g of modified lignin powder (grafted ethylenediamine sodium lignosulfonate powder), dissolved in 20mL of water, after shaking and dispersing, placed in an ultrasonic cleaner for ultrasonic dispersion for 10 minutes, and then used ultrasonic The cell pulverizer was crushed for 20 minutes (the frequency was 300w, the ultrasonic time was 2s, and the pause time was 3s), rinsed and cooled with running water, and pure ammonia water was added dropwise to adjust the pH to 10, then oscillated to disperse to make it a stable suspension. Preparation of oil phase: Measure 150g of cyclohexane and ethanol (mass ratio: 17:3) mixed solution containing 2.55g of Span 80, put it in an ultrasonic cleaner, stir and disperse for 5 minutes, and make it fully mixed. Compounding: Pour the prepared water phase into the oil phase, s...

Embodiment 2

[0060] Example 2 Fe 3 o 4 Preparation of / ALS Composite Drug Carrier Nanoparticles

[0061] Water phase preparation: weigh 0.02g of nano-Fe 3 o 4 Particles (20nm) and 0.06g of modified lignin powder (grafted ethylenediamine sodium lignosulfonate powder), dissolved in 20mL of water, after shaking and dispersing, placed in an ultrasonic cleaner for ultrasonic dispersion for 10 minutes, and then used ultrasonic The cell pulverizer was crushed for 20 minutes (the frequency was 300w, the ultrasonic time was 2s, and the pause time was 3s), rinsed and cooled with running water, and pure ammonia water was added dropwise to adjust the pH to 10, then oscillated to disperse to make it a stable suspension. Preparation of oil phase: Measure 150g of cyclohexane and ethanol (mass ratio: 17:3) mixed solution containing 2.55g of Span 80, put it in an ultrasonic cleaner, stir and disperse for 5 minutes, and make it fully mixed. Compounding: Pour the prepared water phase into the oil phase, ...

Embodiment 3

[0062] Example 3 Fe 3 o 4 Preparation of / ALS Composite Drug Carrier Nanoparticles

[0063] Water phase preparation: weigh 0.02g of nano-Fe 3 o 4 Particles (20nm) and 0.08g of modified lignin powder (grafted ethylenediamine sodium lignosulfonate powder), dissolved in 20mL of water, after shaking and dispersing, placed in an ultrasonic cleaner for ultrasonic dispersion for 10 minutes, and then used ultrasonic The cell pulverizer was crushed for 20 minutes (the frequency was 300w, the ultrasonic time was 2s, and the pause time was 3s), rinsed and cooled with running water, and pure ammonia water was added dropwise to adjust the pH to 10, and then shaken to disperse to make it a stable suspension. Preparation of oil phase: Measure 150g of cyclohexane and ethanol (mass ratio: 17:3) mixed solution containing 2.55g of Span 80, put it in an ultrasonic cleaner, stir and disperse for 5 minutes, make it fully mixed and compound: prepare Pour the water phase into the oil phase, set t...

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Abstract

The invention discloses a lignin-based pH response type magnetic nano-drug carrier as well as a preparation method and application thereof. The preparation method comprises the following steps: firstly, carrying out amination modification on sodium lignin sulfonate through Mannich reaction, so that the sodium lignin sulfonate becomes amphiphilic macromolecules with pH responsiveness; then compounding by using cyclohexane and ethanol as oil phases and lignin and a magnetic Fe3O4 aqueous solution as an aqueous phase through an inverse emulsion crosslinking method; and finally, adding a cross-linking agent to react to obtain the composite nano-carrier. Lignin molecules can be uniformly cross-linked on Fe3O4 nano-particles in a reversed-phase suspension, the synthesized drug-loaded nano-particles are good in monodispersity, the particle size can be lower than 200 nm, the morphology is spherical, the drug loading rate and the release rate are high, and a constructed drug delivery system provides valuable data and reference for accurate control and treatment of cancers and has good application prospects. And a theoretical basis is provided for clinical application of doxorubicin hydrochloride targeted therapy.

Description

technical field [0001] The invention belongs to the field of biomedical drug carriers, in particular to a lignin-based pH-responsive magnetic nano drug carrier and its preparation method and application. Background technique [0002] At present, the main means of treating cancer are surgery, radiotherapy and chemotherapy. However, these methods have shortcomings such as unclean tumor resection, no specific recognition effect, and systemic side effects. Therefore, the design of a controllable drug carrier has attracted extensive attention of researchers. The controllable drug carrier has targeting properties, can accurately transport drugs, and improve the half-life of drugs in the body, which is not only effective in preventing the spread of cancer cells. Significantly, but also greatly improve the treatment effect. [0003] Lignin is the second most productive natural polymer after cellulose, and it is also a renewable resource with aromatic units as the main structural u...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K31/704A61K41/00A61K47/02A61K47/30A61P35/00C08H7/00
CPCA61K9/146A61K9/143A61K31/704A61P35/00A61K47/30A61K47/02A61K41/00C08H6/00
Inventor 郑大锋刘倩邱学青
Owner SOUTH CHINA UNIV OF TECH
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