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Composite kaolinite diagnosis and treatment agent as well as preparation method and application thereof

A kaolinite and compound technology, applied in the field of tumor drugs, can solve the problems of rapid systemic clearance, limited anti-cancer effect, poor bioavailability, etc., and achieve excellent anti-tumor performance, prevent aggregation, and eliminate tumors.

Active Publication Date: 2022-03-11
CHINA UNIV OF GEOSCIENCES (WUHAN) +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the in vivo application of nano-drug delivery systems still faces many challenges, including poor bioavailability, rapid systemic clearance, limited anticancer effects, and biosafety, etc.
Moreover, multidrug resistance to chemotherapeutic drugs remains a concern in the treatment of

Method used

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  • Composite kaolinite diagnosis and treatment agent as well as preparation method and application thereof
  • Composite kaolinite diagnosis and treatment agent as well as preparation method and application thereof
  • Composite kaolinite diagnosis and treatment agent as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] A kind of preparation of modified kaolinite, the method comprises the following steps: the kaolinite intercalation compound is firstly prepared by step-by-step intercalation method. Take 90mL DMSO and 10mL deionized water into the reaction bottle, weigh 10g of pharmaceutical grade kaolinite into the above reaction bottle. Under the condition of 60°C water bath, the reaction was stirred for 24h. Centrifuge after the reaction is over, wash the obtained precipitate three times with absolute ethanol, and then dry at 60°C for 24 hours to obtain the intercalation complex 1, labeled as Kaolinite-DMSO; weigh 39g of urea (Urea) into the reaction bottle, add 50mL of deionized water, stirred until dissolved to prepare a 13mol / L saturated urea solution. Put 5g Kaolinite-DMSO sample into the above-mentioned reaction bottle, add 50mL urea solution, and stir at room temperature for 24h. After the reaction, it was centrifuged at 8000rpm, and the obtained precipitate was washed three ...

Embodiment 2

[0035] (1) Carbon nitride is prepared according to the following method: Weigh 3g of melamine in a crucible, seal it with tin foil and place it in a muffle furnace for calcination (calcination at 500°C for 4h, then increase the temperature at a rate of 20°C to 550°C, and keep it warm for 2h) After calcination, cool to room temperature to obtain light yellow graphite phase carbon nitride powder, marked as g-C 3 N 4 .

[0036] (2) The carbon nitride quantum dot solution is prepared according to the following method: Weigh 0.2g of g-C prepared in Example 2 3 N 4 Put the powder in a beaker, add 40mL deionized water and 40mL hydrogen peroxide, ultrasonically disperse for 5min, pour it into the reaction kettle, heat at a constant temperature for 12h or 24h, and centrifuge the obtained solution at 8000rpm for 5min to obtain a colorless and transparent supernatant which is carbon nitride quantum Spot solutions, labeled CNQDs-12h and CNQDs-24h, respectively.

Embodiment 3

[0038] A kind of carbon nitride quantum dot solution is prepared according to the following method: take 400mg g-C 3 N 4 Powder (prepared for step (1) in Method 1), dispersed in 400mL deionized water. Put it into a computer microwave ultrasonic ultraviolet combination catalytic synthesizer, under the condition of 1500W, ultrasonic for 16h. The dispersion was left at room temperature for 24h, and then centrifuged at 8000rpm to remove large particles to obtain a colorless and transparent supernatant, which was the exfoliated carbon nitride quantum dot solution, labeled as CNQDs-16h.

[0039] Preparation of a Kaolinite Composite Containing Carbon Nitride Quantum Dots

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Abstract

The invention discloses a kaolinite composite diagnosis and treatment agent as well as a preparation method and application thereof. The kaolinite composite diagnosis and treatment agent takes modified kaolinite as a carrier and is loaded with carbon nitride quantum dots and adriamycin. The preparation method of the kaolinite composite diagnosis and treatment agent comprises the following preparation processes: S1, performing intercalation, stripping and dipping etching on pharmaceutical-grade kaolinite to prepare modified kaolinite; s2, performing ultrasonic treatment on the modified kaolinite and a carbon nitride quantum dot solution, drying and grinding to obtain a kaolinite compound containing carbon nitride quantum dots; s3, doxorubicin is dissolved in a dark place, then the kaolinite compound containing the carbon nitride quantum dots is added, after the mixture is oscillated in the dark place for a period of time, washing and drying are conducted, and the kaolinite compound diagnosis and treatment agent containing the carbon nitride quantum dots and the doxorubicin is obtained. According to the kaolinite composite diagnosis and treatment agent containing the carbon nitride quantum dots and the adriamycin, the photodynamic therapy effect of the carbon nitride quantum dots is improved, the loading and slow-release effects of adriamycin drugs are improved, and excellent anti-tumor performance is achieved.

Description

technical field [0001] The invention relates to the technical field of tumor drugs, in particular to a kaolinite composite diagnosis and treatment agent and its preparation method and application. Background technique [0002] Traditional cancer treatment methods include surgical resection, radiotherapy, and chemotherapy. In order to obtain better tumor treatment effects, researchers have extensively studied the combination of phototherapy, chemotherapy, gene therapy, or immunotherapy. Chemotherapy is still the most commonly used clinical treatment, however, due to non-selective drug distribution and poor pharmacokinetics, chemotherapy drugs often lead to poor efficacy and severe systemic cytotoxicity. The past decade has seen rapid progress in the design and development of nanoparticles as anticancer drug carriers. However, the in vivo application of nano-drug delivery systems still faces many challenges, including poor bioavailability, rapid systemic clearance, limited an...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K31/704A61K47/52A61P35/00A61K49/08
CPCA61K41/0057A61K31/704A61K47/52A61P35/00A61K49/08A61K2300/00A61K31/275A61K9/5115A61K47/6949A61K47/02
Inventor 杨华明廖娟
Owner CHINA UNIV OF GEOSCIENCES (WUHAN)
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