Doxycycline hydrochloride solution and preparation method thereof

Abstract

The invention provides a doxycycline hydrochloride solution and a preparation method thereof. According to the invention, the highest concentration of doxycycline in the doxycycline hydrochloride solution is 30%, the doxycycline hydrochloride solution can be diluted with water in any proportion to be used as a doxycycline hydrochloride oral solution, the solution has good stability, the stability is good after the solution is mixed with water, and the palatability is not influenced; and the doxycycline hydrochloride solution overcomes the phenomena that existing doxycycline hydrochloride soluble powder is prone to generating precipitates, uneven in dissolution and the like during high-concentration dissolution, solves the problem of high-concentration dissolution of doxycycline hydrochloride, and is suitable for being used in actual production and high in practical value.

Description

Technical field [0001] The invention belongs to the technical field of veterinary drug preparation. More specifically, it relates to a polysethytic solution of hydrochloride and a preparation method thereof. Background technique [0002] According to the "2019 Chinese Antibacterial Pharmacies", the beast antibacterial drug is administered mainly by mixed feeding pathway, accounting for 61.81%, and the drinking water is given by 17.64%. However, in 2019, the Ministry of Agriculture issued an announcement No. 194, requiring all of the promotion of all promoting growth drug feed additives in addition to traditional Chinese medicine from 2020, while livestock bacterial diseases remains currently in scale and individuals. Common diseases in breeding in breeding process. Therefore, in the case where the traditional feed dosage mode is limited by the forbidden prevention, the drinking water administration is simple, fast, stress, and quick start, less labor, and large groups of drugs. W...

AI Technical Summary

Problems solved by technology

There are three major difficulties in the preparation of doxycycline hydrochloride solution: one, the groups such as phenolic hydroxyl group, enol group and amido group contained in the doxycycline hydrochloride structure are easily oxidized and hydrolyzed, resulting in doxycycline hydrochloride in the Under heating condition, or easily oxidize and decompose in solution, very easily cause phenomena such as solution system discoloration, drug content to reduce; Its two, under conditions such as light, easily generate isomer (comprising in doxycycline hydrochloride solution) 4-epidoxycycline, 6-epidoxycycline, etc.), or become the main reason for the deepening of the color of its solution system; third, although studies have shown that the complexation of doxycycline hydrochloride and metal ions can be used Make it form a complex to improve the stability of doxycycline hydrochloride, but further research shows that the complex formed by metal ions and doxycycline does not significantly improve the problem of drug oxidative discoloration

At the same time, because tetracycline drug molecules contain many hydroxyl groups, enol hydroxyl groups and carbonyl groups, the metal ion complexes formed have low solubility, which will affect the absorption of drugs when used as oral solutions.

The instability of doxycycline hydrochloride restricts the preparation and application of the drug solution dosage form

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