High-oxygen-permeability corneal contact lens and preparation method thereof

A corneal contact lens and oxygen transmission rate technology, which are applied in the preparation of polysiloxane macromonomer cross-linking agent materials, the preparation of high oxygen transmission rate corneal contact lenses, and the surface hydrophilic modification of corneal contact lenses. , can solve the problems of low oxygen permeability, low water content of lenses, development and application limitations, etc., to achieve the effect of comfortable wearing and good wetting performance

Pending Publication Date: 2021-11-30
吉林爱惠瞳医用科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At the same time, lenses based on this type of material have low water content and are easy to adhere to the eyeball, affecting the safety and comfort of invisible wear
[0008] Based on the above analysis, the oxygen transmission rate of traditional hydrogel lenses is low. At the same time, there are many limitations in the development and application of silicon-containing hydrogel contact lenses based on dimethylsiloxane.

Method used

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  • High-oxygen-permeability corneal contact lens and preparation method thereof
  • High-oxygen-permeability corneal contact lens and preparation method thereof
  • High-oxygen-permeability corneal contact lens and preparation method thereof

Examples

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Embodiment 1

[0037] The present embodiment discloses a kind of preparation of the polydimethylsiloxane macromonomer cross-linking agent of hydrophilic segment modification, double bond termination, and it comprises the following steps:

[0038] 1. Add KF-6001 (7.5g) into a 100ml branch bottle, insert it into a mechanical stirrer, coat the cock with vacuum ester, connect the branch with a vacuum line, put it in a water bath at 55°C, and dry it in vacuum for 2 hours.

[0039] 2. At the same time, weigh KF-6002 (30g) and add it to a single-necked flask, and the drying method is the same as above.

[0040]Under mechanical stirring at 3300rpm, add IPDI (1.67g), stir at 55°C until completely dissolved, use a 100ul microsampler to absorb DBTDL (100ul) and drop it into the reactor (>10min), and react for 2h.

[0041] 4. Use a syringe to draw KF-6002 (24.8g) into the reactor, use a 100ul micro-sampler to draw DBTDL (100ul) dropwise into the reactor, and react overnight at 55°C.

[0042] 5. Equilib...

Embodiment 2

[0045] This embodiment discloses a kind of preparation method of silicon hydrogel material on the basis of embodiment 1, and it comprises the following steps:

[0046] Measure the polydimethylsiloxane macromonomer crosslinking agent in the embodiment 1 of 41.7% by mass percentage, the N'N-dimethylacrylamide (DMA) of 22.6% by mass percentage, the formazan of 15.9% by mass percentage Acryloyloxypropyl tris(trimethylsiloxane)silane (Tris), 1.0% by mass of Darocur 1173, dissolved in 18.8% by mass of n-propanol diluent, magnetically stirred for 20 minutes, and ultrasonically eliminated Soak for 10 minutes to obtain a polymerization solution for later use. Use a pipette gun to draw 5ml of the polymerization solution and drop it into a polytetrafluoroethylene mold with a 5*5*0.2cm inner groove. After the drop is full, cover the mold with a 6*6*0.2cm glass plate, and place the whole under ultraviolet light. Under light, polymerize for 40min. Lift the glass plate, take off the polyme...

Embodiment 3

[0048] The present embodiment discloses a kind of preparation method of silicon hydrogel contact lens on the basis of embodiment 2, and it comprises the following steps:

[0049] Measure the polydimethylsiloxane macromonomer crosslinking agent in the embodiment 1 of 41.7% by mass percentage, the N'N-dimethylacrylamide (DMA) of 22.6% by mass percentage, the formazan of 15.9% by mass percentage Acryloyloxypropyl tris(trimethylsiloxane)silane (Tris), 1.0% by mass of Darocur 1173, dissolved in 18.8% by mass of n-propanol diluent, magnetically stirred for 20 minutes, and ultrasonically eliminated Soak for 10 minutes to obtain a polymerization solution for later use. Use a pipette to draw 20 μL of the polymerization solution and drop it into the female mold of the polypropylene contact lens mold. After the drip is full, cover the male mold on the mold, place the whole under ultraviolet light, and polymerize for 30 minutes. After the reaction, open the mold, the lens will be attache...

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Abstract

The invention relates to the technical field of corneal contact lenses, and particularly discloses a high-oxygen-permeability corneal contact lens which is made of a high-oxygen-permeability silicone hydrogel material. The high-oxygen-permeability corneal contact lens is prepared from the following components in percentage by mass through a photopolymerization reaction: 27.5 percent to 41.8 percent of a polydimethylsiloxane macromonomer cross-linking agent, 16.8 percent to 20.5 percent of a hydrophilic monomer, 15.9 percent to 22.6 percent of a micromolecular siloxane monomer, 1.0 percent to 2.5 percent of a photoinitiator and 17.5 percent to 25.0 percent of a diluent; the polydimethylsiloxane macromonomer cross-linking agent adopts a hydrophilic segment modified and double bond terminated polydimethylsiloxane macromonomer cross-linking agent. The defects in the prior art are overcome, the oxygen permeation value of the prepared corneal contact lens is 140-150, and the requirement for the most suitable oxygen permeation amount of a human body is met.

Description

technical field [0001] The invention relates to the technical field of contact lenses, in particular to a method for preparing a polysiloxane macromonomer crosslinking agent material, a method for preparing contact lenses with high oxygen transmission rate based on the material, and such contact lenses Surface hydrophilic modification technology. Background technique [0002] Contact lenses (also known as contact lenses) are lenses that are directly worn on the eyeball and are mainly used for vision correction. For some special types of work, people need to wear contact lenses to ensure eye safety. At the same time, due to people's pursuit of beauty, more young people choose to wear colored contact lenses (color contact lenses) to increase their beauty. At present, with the development of science and technology and people's additional requirements for the wearing comfort of contact lenses; therefore, the lens materials of contact lenses have also been continuously updated....

Claims

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Application Information

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IPC IPC(8): C08F290/06C08F222/38C08F230/08C08F2/48C08J7/056C08G77/388G02C7/04C08L51/08C09D133/02C09D187/00
CPCC08F290/068C08F2/48C08J7/056C08J7/042C08G77/388G02C7/049C08J2351/08C08J2433/02C08J2487/00C08F222/385C08F230/085
Inventor 王长江
Owner 吉林爱惠瞳医用科技有限公司
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