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Urethral stent with long-acting antibacterial and anti-stenosis functions and preparation method thereof

An anti-stenosis and functional technology, applied in other medical devices, dilators, drug devices, etc., can solve the problems of poor antibacterial and anti-stenosis effects, and achieve inhibition of overgrowth, increase of lumen specific surface area, good pressure resistance Effect

Active Publication Date: 2021-11-02
NANTONG TEXTILE & SILK IND TECH RES INST +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Common urethral stents include other urethral stents such as silicone urethral stents, metal urethral stents, polyglycolide or polylactide urethral stents, and collagen urethral stents. These types of urethral stents disclosed in the prior art generally have antibacterial and The problem of poor anti-stenosis effect

Method used

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  • Urethral stent with long-acting antibacterial and anti-stenosis functions and preparation method thereof
  • Urethral stent with long-acting antibacterial and anti-stenosis functions and preparation method thereof
  • Urethral stent with long-acting antibacterial and anti-stenosis functions and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0073] A method for preparing a long-acting antibacterial and anti-stenosis function urethral stent, the specific steps are as follows:

[0074] (1) fabric tube is prepared;

[0075]The yarn is made into a fabric tube by the method of textile forming, wherein the yarn is composed of multiple silk filaments with a denier of 7tex and a medical magnesium wire with a denier of 7tex and a developing function; the textile forming adopts a weaving process, and the machine It is an 8-spindle automatic knitting machine, the knitting structure adopts diamond knitting (1 / 1 interweaving), the knitting speed is 40rpm, the gear ratio is 82 / 21, and the knitting height is 25cm;

[0076] The prepared fabric tube is a tubular fabric, the radial compression modulus of the fabric tube is 0.03MPa, the elastic recovery rate is 74.68%, the circumferential expansion breaking strength is 0.03MPa, and the yarn coverage rate is 67.11%;

[0077] (2) Pretreatment;

[0078] Firstly, at a temperature of 5...

Embodiment 2

[0098] A method for preparing a long-acting antibacterial and anti-stenosis function urethral stent, the specific steps are as follows:

[0099] (1) fabric tube is prepared;

[0100] The yarn is made into a fabric tube by textile molding, wherein the yarn is composed of multiple polylactic acid filaments with a denier of 20tex and a medical tantalum wire with a denier of 20tex and a developing function; the textile molding adopts a knitting process, The structure of knitting adopts weft knitting single jersey;

[0101] The prepared fabric tube is a tubular fabric, the transverse stitch density is 25 rows / 5cm, the longitudinal stitch density is 25 rows / 5cm, the loop length is 5mm, and the total density is 2000 loops / 25cm 2 ; The radial compression modulus of the fabric tube is 1.31MPa, the elastic recovery rate is 87.14%, the circumferential expansion breaking strength is 4.88MPa, and the yarn coverage rate is 75.32%.

[0102] (2) Pretreatment;

[0103] Firstly, at a tempera...

Embodiment 3

[0125] A method for preparing a long-acting antibacterial and anti-stenosis function urethral stent, the specific steps are as follows:

[0126] (1) fabric tube is prepared;

[0127] The yarn is made into a fabric tube by textile molding, wherein the yarn is composed of multiple polydioxanone filaments with a denier of 40tex and a medical silver filament with a developing function of a denier of 40tex; Forming adopts weaving process, and the structure of weaving adopts plain weave;

[0128] The prepared fabric tube is a tubular fabric with a warp density of 100 threads / 10 cm and a weft density of 100 threads / 10 cm; the radial compression modulus of the fabric tube is 2.11 MPa, the elastic recovery rate is 81.57%, and the circumferential expansion The breaking strength is 5.79MPa, and the yarn coverage is 66.67%;

[0129] (2) Pretreatment;

[0130] Firstly, at a temperature of 55°C, wash the fabric tube prepared in step (1) with a concentration of 4wt% oxalic acid solution f...

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Abstract

The invention relates to a urethral stent with long-acting antibacterial and anti-stenosis functions and a preparation method thereof, the urethral stent is of a tubular structure and is composed of an inner layer, a middle layer and an outer layer; the middle layer is a fabric tube; the outer layer is a silk fibroin film carrying an anti-stenosis drug; the inner layer is an antibacterial and antifouling coating and is composed of a chitosan-nano silicon dioxide array, villus, micro villus and an antibacterial agent; and the preparation method comprises the following steps: preparing the yarns into fabric tubes by adopting a spinning forming method, preparing the antibacterial and anti-fouling coatings on the inner surfaces of the fabric tubes, and preparing the silk fibroin films carrying the anti-stenosis medicines on the outer surfaces of the fabric tubes, so as to prepare the urethral stent with the long-acting antibacterial and anti-stenosis functions. The method disclosed by the invention is simple, and the prepared urethral stent is smooth in surface and good in biocompatibility, not only has excellent performances such as radial compression force, circumferential expansionary force, bending torsion resistance and elastic resilience, but also has long-acting antibacterial and anti-stenosis functions, and can prevent excessive deposition of urethral collagen tissues, so that the purpose of treating urethral stenosis is achieved.

Description

technical field [0001] The invention relates to the field of biomedical materials, in particular to a urethral stent with long-acting antibacterial and anti-stenosis functions and a preparation method thereof. Background technique [0002] Urethral stricture is a difficult disease in urology, mainly due to scarring of the urethra. At present, the treatment of urethral stricture mainly includes surgical methods such as urethroplasty, urethral incision and regular urethral dilatation. However, these methods have certain limitations. The trauma of urethroplasty is large, the trauma of the incision in the urethra is large, and the probability of restenosis is high. Regular urethral dilation cannot solve the problem fundamentally, and it brings great pain to the patient. Implanting stents in the urethra can effectively treat urethral strictures. Its advantages are good mechanical support properties, keeping the urethra unobstructed for a long time, and allowing patients to urina...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/10A61L31/02A61L31/04A61L31/06A61L31/08A61L31/14A61L31/16A61L31/18A61M29/02
CPCA61L31/10A61L31/14A61L31/148A61L31/16A61L31/18A61L31/088A61L31/06A61L31/048A61L31/022A61M29/02A61M2210/1089A61L2300/216A61L2300/416A61L2300/404A61L2300/606A61L2420/02A61L2420/06A61L2420/08C08L89/00C08L5/08A61L31/04A61L27/54A61L2400/12A61L2400/18D03D3/02D03D1/00D10B2509/06A61M27/008A61M2205/0205A61M2205/0216A61M2207/00
Inventor 李刚李露李峰段立蓉
Owner NANTONG TEXTILE & SILK IND TECH RES INST
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