Health-care composition and capsule for improving immunity function and preparation method of health-care composition and capsule

A composition and immunity technology, applied in the directions of capsule delivery, drug combination, food ingredient functions, etc., can solve the problems of sensitive and unstable biological characteristics, NMN is difficult to store for a long time, cannot achieve good absorption, etc., and achieves in vitro dissolution. The effect of good behavior, enhanced immunity, loose and rounded particles

Pending Publication Date: 2021-11-02
SHANGHAI INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Such highly sensitive and unstable biological characteristics make NMN difficult to store for a long time, and the active ingredients are easily decomposed after direct administration, making it difficult for the body to absorb
Therefore, NMN alone cannot achieve long-term good absorption and give full play to its efficacy, and the side effects of large doses of NMN on the human body are still unclear.

Method used

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  • Health-care composition and capsule for improving immunity function and preparation method of health-care composition and capsule
  • Health-care composition and capsule for improving immunity function and preparation method of health-care composition and capsule
  • Health-care composition and capsule for improving immunity function and preparation method of health-care composition and capsule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] The recipe in this example is as follows:

[0042]

[0043] There is the preparation method of the health-care composition capsule of improving immunity function in the present embodiment, and its specific operation steps are as follows:

[0044] (1) Take by weighing the NMN bulk drug, Ganoderma lucidum spore powder, Dendrobium officinale powder, micropowder silica gel, and microcrystalline cellulose after the prescription amount is passed through a 60-mesh sieve.

[0045] (2) Mix NMN raw material drug, Ganoderma lucidum spore powder, Dendrobium candidum powder and micropowder silica gel uniformly by equal addition method, and pass through a 60-mesh sieve to prepare mixture A.

[0046] (3) Mix the mixed material A with the microcrystalline cellulose weighed in the step (1) according to the equal amount incremental method, and pass through a 60-mesh sieve to prepare the mixed material B.

[0047] (4) Mix the mixture B with the sodium stearyl fumarate weighed in step (1...

Embodiment 2

[0049] The formula is as follows in the present embodiment:

[0050]

[0051]

[0052] The specific operation steps of preparing NMN compound health care capsules in this example are the same as in Example 1.

Embodiment 3

[0054] The formula is as follows in the present embodiment:

[0055]

[0056] The specific operation steps of preparing NMN compound health care capsules in this example are the same as in Example 1.

[0057] NMN compound health capsules are mainly composed of NMN, Dendrobium candidum and Ganoderma lucidum, and the content of crude polysaccharides in Dendrobium candidum powder and Ganoderma lucidum spore powder was determined by the phenol-concentrated sulfuric acid method. The standard curve determined by UV-Vis spectrophotometry is: y=0.0560x-0.0064, r=0.9998. The content of crude polysaccharide (calculated as anhydrous glucose) in every 100mg of Dendrobium officinale powder and Ganoderma lucidum spore powder is about 88.61mg.

[0058] In vitro dissolution study is one of the important evaluation indexes of oral preparations. It can not only simulate the disintegration and dissolution of oral solid preparations in the gastrointestinal tract, but also control the quality ...

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Abstract

The invention relates to a health-care composition and capsule for improving an immunity function and a preparation method. The content of the compound health-care capsule is prepared from the following raw materials in percentage by weight: 25-35% of NMN, 10-15% of ganoderma lucidum spore powder, 10-15% of dendrobium officinale powder, 8-12% of a moisture-proof agent and a flow aid, 30-40% of an adhesive and a diluent and 2-3% of a lubricant. Compared with the prior art, the capsule shell can cover the unpleasant odor of the NNM raw material medicine, contact of light, air and moisture is avoided, and the stability and bioavailability of the medicine are improved; the compound health-care composition can improve the thymus index of a mouse, reduce the ear swelling degree of the mouse, promote lymphocyte proliferation and increase the phagocytic index and NK cell activity of the mouse. The NMN compound health-care capsule prepared by the invention is uniform in content, good in in-vitro dissolution behavior, simple in production process, better in stability and easy for large-scale production.

Description

technical field [0001] The invention relates to the related field of health care products, in particular to a health care composition, capsule and preparation method for improving immune function. Background technique [0002] Hypoimmunity seriously endangers the health of modern humans, and research on improving the body's own immunity is also in progress. [0003] Nicotinamide Mononucleotide (NMN) is Nicotinamide Adenine Dinucleotide (Nicotinamide Adenine Dinucleotide, NAD + ), NMN can increase intracellular NAD + levels, while NAD + It is an important coenzyme for cellular energy conversion. It can restore human DNA cell damage and activate human DNA cells, and improve human immune function. In fact, NAD + DNA damage and immune function decline caused by decreased levels are the key causes of various diseases. [0004] Ganoderma lucidum is the dry fruiting body of Ganoderma Lucidum Karst. or Ganodermasinense Zhao, Xu et Zhang, a fungus of the family Polyporaceae. It...

Claims

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Application Information

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IPC IPC(8): A23L33/13A23L33/10A23L31/00A23P10/30A61K36/8984A61K9/48A61K47/38A61P37/04A61K31/706
CPCA23L33/13A23L33/10A23L31/00A23P10/30A61K31/706A61K36/074A61K36/8984A61K9/4866A61P37/04A23V2002/00A23V2200/324A61K2300/00
Inventor 俞佳敏于燕燕夏郅吴范宏
Owner SHANGHAI INST OF TECH
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