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Titanium dioxide compound with anti-tumor effect

A titanium dioxide and nano-titanium dioxide technology, which is applied in anti-tumor drugs, medical preparations containing active ingredients, heavy metal active ingredients, etc., can solve the problem of not significantly promoting the growth of tumor-bearing host tumors, achieve the ability to inhibit invasion and metastasis, reduce Huge payouts, the effect of prolonging survival time

Pending Publication Date: 2021-10-26
CHANGZHOU MATERNAL & CHILD HEALTH CARE HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although in vitro cell studies have shown that glutamine can promote tumor cell proliferation, the results of in vivo studies are contradictory. Neither parenteral nor enteral nutrition support containing glutamine can significantly promote tumor growth in tumor-bearing hosts. The reason may be that Glutamine can promote the host's positive nitrogen balance and improve the body's immunity. Therefore, it is safe to supplement glutamine to the tumor-bearing body. Research on glutamine metabolism has gradually become a new target and breakthrough in cancer treatment.

Method used

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  • Titanium dioxide compound with anti-tumor effect
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Examples

Experimental program
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Effect test

Embodiment 1

[0021] see figure 1 , a titanium dioxide compound with anti-tumor effect, the synthetic raw materials of the titanium dioxide compound include glutamine, butyl titanate and copper ions, wherein the reaction concentration of the glutamine is 1 mg / ml, and the titanic acid The reaction concentration of butyl ester is 0.5 mg / ml, the reaction concentration ratio of glutamine and butyl titanate is 2:1, the reaction concentration of copper ion is 0.3 μg / ml, the glutamine and The reaction between butyl titanate and the two is used to synthesize nano-titanium dioxide, and the copper ions are used to dope nano-titanium dioxide in the lattice of nano-titanium dioxide to modify nano-titanium dioxide, and the formed titanium dioxide compound is glutamine-nano-titanium dioxide;

[0022] Such as figure 2 as shown, figure 2 The photo in A shows the intermediate state of glutamine-nano-titanium dioxide modified by copper ions in a rod shape, figure 2 Photo B in the picture shows the comp...

Embodiment 2

[0033]Based on a titanium dioxide compound with antitumor effect described in Example 1, when the acute toxicity and accumulation of the titanium dioxide compound are analyzed, the lethal dose of glutamine-nano titanium dioxide is estimated by the half lethal dose of nano titanium dioxide dose. After the concentration was determined by ICP-MS, different concentrations of venom were prepared and administered through tail vein injection to determine the maximum dose, median lethal dose, and absolute lethal dose for nude mice with zero mortality. The LD50 and its 95% confidence interval were calculated by modified Karber method. Observe and record the poisoning symptoms of mice, and the gross and pathological changes of internal organs. The dose-increasing continuous exposure method was adopted, the dose was designed based on LD50, the accumulation coefficient was calculated, and the accumulation was evaluated.

Embodiment 3

[0035] Based on a titanium dioxide compound with anti-tumor effect described in Example 1, when analyzing the pharmacokinetics of the titanium dioxide compound and its ability to reach tumor tissue, the maximum dose of tail vein injection with a lethality of 0 was selected for drug administration. For pharmacokinetic research, a total of 48 hours of blood and tissue samples were taken every hour for subsequent drug content determination. According to the changes in blood and tissue titanium dioxide content, change curves were drawn to calculate the apparent volume of distribution to determine the efficacy of the drug. Distribution and degree of integration with the organization. The half-life, clearance rate and elimination kinetics of glutamine-nano-titanium dioxide were calculated by the content of titanium dioxide in plasma. Tumor cells were cultured in vitro, inoculated subcutaneously in the middle and back of the axilla of nude mice, nude mice with good tumor formation we...

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Abstract

The invention discloses a titanium dioxide compound with an anti-tumor effect, and belongs to the technical field of biological pharmacy. Synthesis raw materials of the titanium dioxide compound comprise glutamine, butyl titanate and copper ions, the reaction concentration of the glutamine is 1 mg / ml, the reaction concentration of the butyl titanate is 0.5 mg / ml, the reaction concentration ratio of the glutamine to the butyl titanate is 2: 1, the reaction concentration of the copper ions is 0.3 microgramme / ml, the glutamine and the butyl titanate react to synthesize the nano titanium dioxide, and the copper ions are used for doping into crystal lattices of the nano titanium dioxide to modify the nano titanium dioxide. Through a mechanism of disturbing phase separation and inhibiting tumor cell invasion and metastasis capability, a new thought is provided for subsequent pharmaceutical design, so that the drug synthesis cost is controllable, the drug research and development cost can be greatly reduced, and the huge expenditure of tumor patient families is reduced.

Description

technical field [0001] The invention belongs to the technical field of biopharmaceuticals, in particular to a titanium dioxide compound with antitumor effect. Background technique [0002] Cancer cells have the characteristics of "glutamine addiction". They will enrich a large amount of glutamine for their own rapid growth. Therefore, although glutamine is the most abundant amino acid in the body, glutamine often occurs in tumor-bearing bodies. Glutamine deficiency, so the supplemental glutamine will be quickly delivered to the tumor tissue. Although in vitro cell studies have shown that glutamine can promote tumor cell proliferation, the results of in vivo studies are contradictory. Neither parenteral nor enteral nutrition support containing glutamine can significantly promote tumor growth in tumor-bearing hosts. The reason may be that Glutamine can promote the host's positive nitrogen balance and improve the body's immunity. Therefore, it is safe to supplement glutamine t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/24A61P35/00A61P35/04
CPCA61K33/24A61P35/00A61P35/04A61K31/198A61K33/34A61K2300/00
Inventor 冒志磊王淮燕周军张克良秦志强陈科锦
Owner CHANGZHOU MATERNAL & CHILD HEALTH CARE HOSPITAL
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