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Dental repair composite resin with bacteriostasis-remineralization dual functions as well as preparation and application thereof

A composite resin and dental restoration technology, applied in dental preparations, dentistry, dental prosthesis, etc., can solve the problem of slow dissolution rate of pure hydroxyapatite ions, pure hydroxyapatite does not have antibacterial biological activity, promotes biological Limited mineralization performance and other issues, to achieve the effect of promoting mineral deposition, improving long-term service performance, and controlling crystal form and size

Pending Publication Date: 2021-10-15
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, as an inorganic filler for composite resins, due to the slow dissolution rate of highly crystalline pure hydroxyapatite ions, the ability to promote biomineralization is relatively limited, and pure hydroxyapatite does not have antibacterial biological activity

Method used

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  • Dental repair composite resin with bacteriostasis-remineralization dual functions as well as preparation and application thereof
  • Dental repair composite resin with bacteriostasis-remineralization dual functions as well as preparation and application thereof
  • Dental repair composite resin with bacteriostasis-remineralization dual functions as well as preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] (1) Preparation of Sr-HAp nanoparticles

[0049] Weigh 4.25g of diammonium hydrogen phosphate, pour it into a three-necked flask filled with 100mL of deionized water, add magnets and stir in a 90°C oil bath until completely dissolved, adjust the pH to 10 with ammonia water, and weigh calcium nitrate tetrahydrate 10.03g and 1.59g of strontium nitrate were poured into a flask filled with 100mL of deionized water, added a magnet and stirred in an oil bath at 90°C until completely dissolved, then added dropwise to a three-necked flask, keeping the pH of the reaction system at 10, After the dropwise addition was completed, stirring was continued for 5 hours. After the reaction was completed, it was centrifuged and washed with deionized water, and dried to obtain Sr-HAp with a calcium substitution molar percentage of 15%.

[0050] (2) Silanization modification of Sr-HAp

[0051] Measure 90mL of ethanol, 10mL of deionized water, and 2.5mL of KH570 in a 250mL beaker, sonicate...

Embodiment 2

[0053] (1) Preparation of Zn-HAp nanoparticles

[0054] Weigh 4.25g of diammonium hydrogen phosphate, pour it into a three-necked flask filled with 100mL of deionized water, add magnets and stir in a 90°C oil bath until completely dissolved, adjust the pH to 10 with ammonia water, and weigh calcium nitrate tetrahydrate 10.03g, 2.23g of zinc nitrate hexahydrate, poured into a flask equipped with 100mL of deionized water, added a magnet, stirred in a 90°C oil bath until completely dissolved, then added dropwise to a three-necked flask, keeping the pH of the reaction system = 10. After the dropwise addition, continue to stir for 3 hours. After the reaction is completed, it is centrifuged and washed with deionized water, and dried to obtain a Zn-HAp with a calcium substitution molar percentage of 15%.

[0055] (2) Silanization modification of Zn-HAp

[0056] The Sr-HAp particles in step (2) of Example 1 were replaced with Zn-HAp particles to obtain silanized modified Zn-HAp part...

Embodiment 3

[0058] (1) Preparation of strontium / zinc co-doped hydroxyapatite Sr / Zn-HAp nanoparticles

[0059] Weigh 4.25g of diammonium hydrogen phosphate, pour it into a three-necked flask filled with 100mL of deionized water, add magnets and stir in a 90°C oil bath until completely dissolved, adjust the pH to 10 with ammonia water, and weigh calcium nitrate tetrahydrate 10.03g, 0.79g of strontium nitrate, and 1.12g of zinc nitrate hexahydrate were poured into a flask filled with 100mL of deionized water, added with a magnet, stirred in an oil bath at 90°C until completely dissolved, and then added dropwise into a three-necked flask. Keep the pH of the reaction system = 10, and continue stirring for 3 hours after the dropwise addition. After the reaction, it was centrifuged and washed with deionized water, and dried to obtain Sr / Zn-HAp particles with a strontium / zinc doping ratio of 1:1 and a calcium substitution molar percentage of 15%.

[0060] (2) Silanization modification of Sr / Zn-H...

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Abstract

The invention relates to dental repair composite resin with bacteriostasis-remineralization dual functions and preparation and application thereof. The composite resin comprises an inorganic filler, a resin matrix and a photoinitiator, wherein the inorganic filler is a compound of silanization modified strontium / zinc mono-and co-doped hydroxyapatite nanoparticles and barium glass powder. According to the method, strontium / zinc doped hydroxyapatite is well dispersed and well combined with a resin matrix, and the method is simple, low in cost, low in equipment requirement and suitable for large-scale production; the obtained product has lasting bacteriostasis and remineralization capability, the color does not influence the beauty, the biocompatibility is excellent, and the long-term life and the curative effect of a prosthesis can be remarkably improved when the product is applied to the oral cavity as a decayed tooth filling and repairing material.

Description

technical field [0001] The invention belongs to the field of dental restoration materials and their preparation and application, in particular to a dental restoration composite resin with dual functions of antibacterial and remineralization, and its preparation and application. Background technique [0002] Dental caries is a common oral disease, which is listed by the World Health Organization as one of the three major non-communicable diseases that should be prevented and controlled in the 21st century. The incidence of dental caries is high, and improper treatment can lead to inflammation in multiple parts of the oral cavity, and even other systemic diseases such as arthritis, myocarditis, and eye diseases. Silver amalgam has been used since the early 19th century and has long occupied a dominant position in dental restoration materials. However, this material has defects such as thermal and electrical conductivity, poor aesthetics, and biological risks, which limit its ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K6/75A61K6/77A61K6/71A61K6/62A61K6/887A61K6/69A61K6/15
CPCA61K6/75A61K6/77A61K6/71A61K6/62A61K6/887A61K6/69A61K6/15C08L33/10
Inventor 蔡晴李业晨张代兴万卓于运花杨小平
Owner BEIJING UNIV OF CHEM TECH
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