Novel composite bone cement with biological activity

Abstract

The invention discloses novel composite bone cement with biological activity, raw materials comprise powder and liquid, the powder comprises the following parts in percentage by mass: 39%-84.3% of polymethyl methacrylate microspheres, 5%-15% of zirconium dioxide, 0.5%-3% of benzoyl peroxide, 0.2%-2% of gentamicin sulfate and 10%-41% of strontium-magnesium co-doped hydroxyapatite whiskers, The liquid comprises the following parts in percentage by mass: 98-99.6% of methyl methacrylate and 0.4-2% of N, N-dimethyl p-toluidine, mixing the powder and the liquid, stirring, standing, shaping and curing to obtain the novel composite bone cement. Bone-like apatite can be induced to be deposited on the surface of the bone cement in in-vitro simulated human body fluid, new bones can be promoted to grow on the interface of the bone cement and bone tissues in animal model rabbit bodies, good biological activity and osteogenesis promoting capacity are shown, and the compressive strength, bending strength and bending elastic modulus of the bone cement are all higher than those of conventional bone cement.

Description

technical field [0001] The invention relates to the field of biomedical polymer materials, in particular to a novel composite bone cement with good biological activity, which can induce the nucleation and deposition of bone-like apatite in simulated human body fluid in vitro, and can promote the growth of new bone in vivo. The interface between bone cement and bone tissue is replaced by mechanical linkage to osseointegration, thereby reducing aseptic inflammation and loosening, and prolonging the service life of the joint prosthesis in the human body. Background technique [0002] After years of clinical practice and postoperative follow-up, the conventionally used polymethyl methacrylate (PMMA) bone cement has certain performance defects, mainly as follows: it does not degrade itself, has poor fusion with surrounding bone tissue, and relies on mechanical interlocking. Connected with bone tissue, this physical connection mechanism is prone to failure when the material is def...

AI Technical Summary

Problems solved by technology

However, the active material inside the PMMA matrix loses its modification effect, and the method of increasing the amount of addition in order to shorten the osteogenesis period will deteriorate the mechanical properties of the matrix.

[0004] However, the above-mentioned modification ideas have their own disadvantages, and it is still impossible to obtain bone cement materials with ideal performance.

Images