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Umbilical cord mesenchymal stem cell active peptide secretion, preparation method, application and skin micro-ecological regulator

A technology of microecological regulator and stem cell, which is applied in the field of beauty and skin care, can solve the problems of not seeing the microecology of the skin surface, paying less attention to the microecology of the skin surface, etc.

Active Publication Date: 2021-08-24
HARVEST BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the research and development process of existing cosmetics seldom pays attention to the microecology of the skin surface, and there are no reports of cosmetics that have a regulating effect on the microecology of the skin surface. In view of this, the present invention is proposed

Method used

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  • Umbilical cord mesenchymal stem cell active peptide secretion, preparation method, application and skin micro-ecological regulator
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  • Umbilical cord mesenchymal stem cell active peptide secretion, preparation method, application and skin micro-ecological regulator

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preparation example Construction

[0052] In a fourth aspect, the present invention provides a skin microecology regulator, comprising the secretion described in any one of the foregoing embodiments or the secretion prepared by using the preparation method described in any one of the foregoing embodiments.

[0053] In an optional embodiment, the conditioner further includes at least one of a moisturizer, an emulsifier, a thickener or a preservative / bacteriostat.

[0054] Preferably, the humectant includes butylene glycol, glycerin, 1,3-propanediol, pentylene glycol, isopentyl glycol, diglycerol, triglycerol, polyglycerol, sorbitol, polyethylene glycol, poly At least one of propylene glycol, ethylene glycol or diethylene glycol.

[0055] Preferably, the emulsifier includes stearic acid, cetearyl alcohol, cetearyl dextrose, cetearyl ethylhexanoate, steareth-20, cetyl phosphate at least one of potassium, lanolin wax, or coconut oil PEG-10 ester.

[0056] Preferably, the thickener comprises C 14 ~C 22 Alcohol, ...

Embodiment 1

[0063] This example provides a method for preparing active peptide secretion from umbilical cord mesenchymal stem cells, comprising the following steps:

[0064] 1.1 Separation of umbilical cord Wharton's jelly

[0065] (1) Collect the umbilical cord, put the umbilical cord into a sterile disposable umbilical cord collection bottle, immerse it in the preservation solution, tighten the bottle cap, and store it in a refrigerator at 4°C; the length of the umbilical cord is measured to be 55cm in a sterile environment, and then the umbilical cord Cut into small sections with a length of 2 cm, remove the arteries and veins of the umbilical cord, and separate to obtain Wharton's jelly.

[0066] (2) Collect Wharton's jelly, add 1-2mL MEM-alpha medium dropwise, cut Wharton's jelly into pieces, and form a paste.

[0067] (3) Take 1 mL of Wharton's jelly cut into pieces in step (2) and add it to the cell culture dish, then add 2 to 3 mL of MEM-alpha medium, completely cover the bottom ...

Embodiment 2

[0074] In this example, the active peptide secretion of umbilical cord mesenchymal stem cells obtained in Example 1 was used to prepare a skin microecological adjustment cream, the composition of which is shown in Table 2.

[0075] The skin microecological adjustment cream component list that table 2 embodiment 2 provides

[0076]

[0077]

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Abstract

The invention relates to the technical field of beauty and skin care, in particular to umbilical cord mesenchymal stem cell active peptide secretion, a preparation method, application and a skin micro-ecological regulator. The umbilical cord mesenchymal stem cells secrete a plurality of active peptide molecules into the environment, and have diversified regulation functions on the cells. The inventor unintentionally discovers that the umbilical cord mesenchymal stem cells not only can regulate skin cells, but also can regulate microbial population distribution on the skin surface. In the research, the inventor discovers that the umbilical cord mesenchymal stem cell active peptide secretion can have a positive regulation effect on a probiotic Stophylococcus epidermidis, and in addition, other bacterial colonies subjected to significant regulation are not reported to be directly related to skin problems. Therefore, it is determined that the umbilical cord mesenchymal stem cell secretions can regulate the skin surface micro-ecology.

Description

technical field [0001] The invention relates to the technical field of beauty and skin care, in particular to an active peptide secretion of umbilical cord mesenchymal stem cells, a preparation method, an application and a skin microecological regulator. Background technique [0002] Skin microorganisms are important members of the skin micro-ecosystem, and the flora on the skin surface can usually be divided into resident bacteria and transient bacteria. Resident bacteria are a group of microorganisms that colonize healthy skin and are closely related to skin health, including Staphylococcus, Corynebacterium, Propionibacterium, Acinetobacter, Malassezia, Micrococcus, Enterobacter and Klebsiella, etc. . Transient bacteria refer to a class of microorganisms acquired through contact with the external environment, including Staphylococcus aureus, Streptococcus hemolyticus, and Enterococcus, which are the main pathogenic bacteria that cause skin infections. [0003] There is c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/99A61K8/98A61K8/64A61Q17/00A61Q19/00C12N5/0775
CPCA61K8/99A61K8/981A61K8/64A61Q17/005A61Q19/00C12N5/0668C12N2509/00Y02A50/30
Inventor 李钧翔陆益康思宁范元亮
Owner HARVEST BIOTECH CO LTD
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