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Application of flavonoid compound to preparation of cholinesterase inhibitor and medicine for preventing and/or treating Alzheimer disease

A technology of flavonoids, Alzheimer's disease, applied in the field of medicine, can solve problems such as level reduction

Pending Publication Date: 2021-08-20
QIQIHAR UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

With the rapid growth of the world's elderly population, neurodegenerative diseases have become a very serious problem. The decrease in the level of neurotransmitter acetylcholine in the brain is one of the important reasons for this problem. At present, there is no clinical drug that can completely protect neurons , but inhibiting the degradation of acetylcholine inside the nerve has become the main means of treating patients with Alzheimer's disease in the early and middle stages

Method used

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  • Application of flavonoid compound to preparation of cholinesterase inhibitor and medicine for preventing and/or treating Alzheimer disease
  • Application of flavonoid compound to preparation of cholinesterase inhibitor and medicine for preventing and/or treating Alzheimer disease
  • Application of flavonoid compound to preparation of cholinesterase inhibitor and medicine for preventing and/or treating Alzheimer disease

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Embodiment 1

[0036] To extract the compound eriosematin, proceed as follows:

[0037] Take the root of the vine root, use the root bark, pulverize it through a pulverizer, pass through an 80-mesh sieve, and take the part under the sieve as a sample of the root, and store it in a dark place at room temperature (25°C).

[0038] Use 80% ethanol aqueous solution to carry out reflux extraction on 500g jackbar sample, the ratio of solid to liquid is 1:12g / mL, the extraction temperature is 55°C, the number of extractions is 2 times, and the time of each extraction is 60min; After completion, the filtrate was collected by filtration, and the combined filtrate was concentrated in vacuo to obtain an ethanol extract (60 g), which was a dark red gum;

[0039] Using n-hexane-ethyl acetate as the eluent, under gradient elution conditions, the ethanol extract was eluted with an open silica gel column, and 5 fractions were obtained in sequence, which were denoted as fraction A, fraction B, fraction C, fl...

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Abstract

The invention provides an application of a flavonoid compound to preparation of a cholinesterase inhibitor and a medicine for preventing and / or treating Alzheimer's disease, and belongs to the technical field of medicines. The invention provides the application of the flavonoid compound to preparation of the cholinesterase inhibitor. The flavonoid compound is specifically a compound Eriosematin. According to the invention, the compound Eriosematin has extremely efficient inhibition activity on cholinesterase, and can be used for preventing and / or treating Alzheimer's disease caused by cholinergic system damage.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of a flavonoid compound in the preparation of cholinesterase inhibitors and drugs for preventing and / or treating Alzheimer's disease. Background technique [0002] Alzheimer's disease (AD) is a chronic neurodegenerative disease that usually begins in late middle age or old age. The severe brain atrophy of AD patients, the senile plaques formed by the aggregation of β-amyloid protein outside the nerve cells and the neurofibrillary tangles formed by the hyperphosphorylation of Tau protein inside the nerve cells, cause neuron damage and death, and the continuous degeneration of neurons leads to the death of patients. Clinically, it shows symptoms such as progressive memory loss, impaired thinking, disorientation, mood and personality changes. [0003] Due to the complex pathogenesis of AD and the pathogenesis involving a variety of physiological changes in the brai...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61P25/28
CPCA61K31/352A61P25/28
Inventor 王岩于璐王雪松刘文宇孙虹迪
Owner QIQIHAR UNIVERSITY
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