Implantable bandage for promoting bone injury repair and preparation method thereof

Abstract

The invention discloses an implantable bandage for promoting bone injury repair and a preparation method thereof. The bandage is composed of a porous grid sheet-shaped object and organic-inorganic composite superfine fiber porous film covering objects on the surfaces of the two sides of the porous grid sheet-shaped object, the lower layer is a superfine fiber porous network containing bioglass particles, the middle layer is a polymer porous grid, and the upper layer is a superfine fiber porous network containing inorganic mineral particles; inorganic matters in the superfine fibers on the surfaces of the two sides are bioglass particles for inhibiting inflammation, resisting infection and promoting soft tissue regeneration and repair and inorganic mineral particles for inhibiting inflammation and promoting bone regeneration and repair, and the bandage is prepared through three-dimensional printing and electrostatic spinning processes. The method is convenient to operate, has a remarkable inhibition effect on inflammation in soft and hard tissues such as muscles, periosteum and bones with various fractures or bone defects, promotes rapid healing and repair of the soft and hard tissues, is adjustable in degradation rate of the implantable bandage, and has a remarkable bacteriostasis effect on common pathogenic bacteria and fungi.

Description

technical field [0001] The invention belongs to the field of biomedical implant materials, and relates to an implant bandage and a preparation method thereof, in particular to an implant bandage material and a preparation method for promoting synergistic regeneration and repair of soft and hard tissues in bone damage. Background technique [0002] Bone injuries usually include fractures and bone defects, which can also be called bone trauma and bone loss. In my country, more than 100,000 people die every year from fractures or bone trauma caused by accidents such as traffic accidents, falls, bruises, and falls, and millions of people suffer from bone fractures caused by various operations, diseases, and inflammations. Defects or bone loss, especially in middle-aged and elderly people with various chronic diseases and inflammations that cause bone damage, poor blood supply and slow recovery, resulting in delayed fracture union, malunion or even nonunion (nonunion). Although c...

AI Technical Summary

Problems solved by technology

[0005] One is that the continuous inflammatory response caused by muscle tissue trauma may have an adverse effect on the internal repair of bone damage, and the need for timely healing of muscle trauma and the prevention and control of infection

[0006] The second is that the blood supply in the bone defect is seriously affected after the periosteum is damaged. The reconstruction and repair process of the periosteum itself cannot provide positive support for the nutrition supply for the repair of the bone injury, and the lack of periosteum-derived stem cells will also endanger the improvement of the healing efficiency of the bone injury.

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