Substrate material for detecting meso compound with multiple chiral centers

A technology of base material and chiral center, which is used in material analysis by optical means, molybdenum compounds, nanotechnology for materials and surface science, etc. Achieve the effect of low cost, little interference and accurate results

Active Publication Date: 2021-07-20
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because it has multiple chiral centers and the optical activities of these chiral centers cancel each other out, it cannot show optical activity, and cannot be analyzed and detected by common optical methods.
In addition, for some meso-multichiral center compounds, there is no chiral chromatographic column that meets its adsorption characteristics in the prior art, and analysis and detection cannot be achieved by chromatography.

Method used

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  • Substrate material for detecting meso compound with multiple chiral centers
  • Substrate material for detecting meso compound with multiple chiral centers
  • Substrate material for detecting meso compound with multiple chiral centers

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] In this embodiment, the R-type silver molybdate mesoscopic structure film is used as the base material. The R-type silver molybdate mesoscopic structure film is prepared by an induced growth method, which specifically includes the following steps:

[0042] Step S1, perform hydrophilic treatment on the clean molybdenum substrate, that is, place the molybdenum substrate in a mixed solution containing concentrated sulfuric acid and hydrogen peroxide, heat it at 60°C for 2 hours and ultrasonicate for half an hour, then take out the substrate and wash it with deionized water three times;

[0043] Step S2, putting the hydrophilized substrate into 5% mercaptosilylating reagent and standing for 2 hours for mercaptolation, then taking out the substrate and washing it three times with ethanol and deionized water;

[0044] Step S3, putting the thiolated substrate into a mixed solution containing 66 mM silver nitrate and 50 mM chiral inducer (L-phenylglycine or D-phenylglycine) an...

Embodiment 2

[0059] In this example, the same R-type silver molybdate mesoscopic structure film as in Example 1 was used as the base material. Basepiperidine and (3R,4S)-4-(4-ethoxyphenyl)-3-hydroxymethyl-1-methylpiperidine are detected, and the preparation method of the R-type silver molybdate mesoscopic structure film It is also the same as the first embodiment, and will not be repeated here.

[0060] Figure 8 It adopts the R-type silver molybdate mesoscopic structure membrane of the embodiment of the present invention to (3S, 4R)-4-(4-ethoxyphenyl)-3-hydroxymethyl-1-methylpiperidine and ( 3R,4S)-4-(4-ethoxyphenyl)-3-hydroxymethyl-1-methylpiperidine mixture for detection of Raman spectrum.

[0061] Figure 8 Among them, -100% is a sample containing only (3R,4S)-4-(4-ethoxyphenyl)-3-hydroxymethyl-1-methylpiperidine, and 100% is a sample containing only (3S,4R )-4-(4-ethoxyphenyl)-3-hydroxymethyl-1-methylpiperidine sample, -50% is (3R,4S)-4-(4-ethoxyphenyl) The content ratio of -3-hy...

Embodiment 3

[0075] In this example, in order to verify the influence of different preparation conditions on silver molybdate mesostructure films, different conditions were used to prepare different silver molybdate mesostructure films, and these silver molybdate mesostructure films were used as substrate materials respectively Carry out Raman spectroscopy detection test.

[0076] In this embodiment, three kinds of silver molybdate mesostructure films were prepared. The three preparation processes were the same as in Example 1, but the conditions were different, as follows:

[0077] The first kind: the amount of ammonia water in step S4 is changed to 35mM;

[0078] The second type: the amount of ammonia water in step S4 is changed to 10mM;

[0079] The third method: the amount of D-phenylglycine in step S4 is changed to 30mM.

[0080] Figure 12 It is the low-magnification scanning electron micrograph of the R-type silver molybdate mesoscopic structure membrane that the ammoniacal liquo...

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Abstract

The invention provides a substrate material for detecting a meso compound with multiple chiral centers, the substrate material is matched with a Raman spectrometer for use so as to detect the meso compound with multiple chiral centers, and the substrate material is characterized in that the substrate material is a chiral surface plasma resonance material composed of molybdate. The substrate material can perform specific Raman scattering signal enhancement on the meso compound with multiple chiral centers, and the enhancement degrees of the substrate material on different enantiomers are different, so that the content proportion of the enantiomers in the meso compound with multiple chiral centers can be calculated according to the spectral intensity in a Raman spectrum. Compared with the detection means in the prior art, the detection of the meso compound with multiple chiral centers can be realized by combining the substrate material with the Raman spectrometer, and the substrate material has the advantages of low cost, simplicity in operation, small interference, accurate result and the like.

Description

technical field [0001] The invention relates to a base material used for detecting mesogenic polychiral center compounds. Background technique [0002] Chiral compounds refer to a class of compounds that have the same molecular structure but are mirror images of each other in configuration. Chirality will induce differences in the properties of isomers. For example, left-handed and right-handed molecules have different tastes. Especially in the field of pharmaceutical and chemical engineering, a pair of chiral compounds that are mirror images of each other usually have different pharmacological activities. For example, in the well-known incident of thalidomide, many pregnant women gave birth to deformed fetuses after taking thalidomide. This is because only the R-isomer is sedative and the S-isomer is teratogenic. Therefore, the development of efficient and sensitive chiral analysis methods is of great significance for the stereoselective synthesis of enantiomers, the phar...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/65C01G39/00B82Y30/00B82Y40/00
CPCG01N21/658C01G39/00B82Y30/00B82Y40/00
Inventor 车顺爱林海明段瑛滢
Owner TONGJI UNIV
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