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Absorbable iron-based instrument

An iron-based and device technology, applied in the field of medical devices, can solve problems such as easy aggregation of drugs, difficulty in achieving therapeutic effects, weak drug release, etc., to avoid adverse tissue reactions, improve effective utilization, and increase thrombogenicity Effect

Active Publication Date: 2021-07-16
BIOTYX MEDICAL (SHENZHEN) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As a drug carrier, when the molecular weight of the degradable polymer is too large, the drug is easy to aggregate, resulting in poor drug dispersion, which will lead to severe drug release after implantation, and long-term drug release is weak, that is, the effective utilization rate of the drug is low. Unreasonable drug release pattern, difficult to achieve ideal therapeutic effect

Method used

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  • Absorbable iron-based instrument
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Examples

Experimental program
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preparation example Construction

[0036] The preparation methods of the zinc-containing protective layer 200 include, but are not limited to, electroplating, electroless plating, spray coating, dip coating, brush coating, vapor deposition, magnetron sputtering, mechanical embedding, and ion implantation. In one embodiment, when the material of the zinc-containing protective layer 200 is a zinc alloy, it may be a zinc-containing protective layer formed by alloying a zinc alloy material in situ after forming a pure zinc layer on the surface of the iron-based substrate 100. Layer 200.

[0037] The corrosion promotion layer 300 covers the zinc-containing protective layer 200 , and the corrosion promotion layer 300 completely covers the surface of the iron-based substrate 100 .

[0038] The material of the corrosion-promoting layer 300 is a material that can produce acidic products during degradation, making the local environment into a low pH value environment, so as to promote the corrosion of the iron-based subs...

Embodiment 1

[0084] An iron-based support, its specific preparation method is as follows: adopt electroplating method to be galvanized on the nitrided iron-based base body of 30008 specification that wall thickness is 50 microns, internal diameter is 1.45mm, obtains covering the entire surface of iron-based base body, thickness (1 micron) uniform zinc-containing protective layer. Wherein, the grain size of zinc in the zinc-containing protective layer is submicron. Subsequently, an ethyl acetate solution of PDLLA with a weight-average molecular weight of 200 kDa was sprayed, and after the solvent was dried, a corrosion-promoting layer that completely covered the zinc-containing protective layer was obtained. During the spraying process, a polytetrafluoroethylene (PTFE) core rod is installed inside the iron-based substrate to obtain a corrosion-promoting layer with different thicknesses on the inner and outer walls. The thickness of the part of the corrosion-promoting layer located on the o...

Embodiment 2

[0087] An iron-based support, its specific preparation method is as follows: adopt electroplating method to be galvanized on the nitrided iron-based base body of 30008 specification that wall thickness is 50 microns, internal diameter is 1.45mm, obtains covering the entire surface of iron-based base body, thickness (1 micron) uniform zinc-containing protective layer. Wherein, the grain size of zinc in the zinc-containing protective layer is submicron. Subsequently, an ethyl acetate solution of PDLLA with a weight-average molecular weight of 200 kDa was sprayed, and after the solvent was dried, a corrosion-promoting layer that completely covered the zinc-containing protective layer was obtained. During the spraying process, a PTFE core rod is installed inside the iron-based substrate to obtain a corrosion-promoting layer with different thicknesses on the inner wall and outer wall. The thickness of the part of the corrosion-promoting layer located on the outer wall of the iron-...

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Abstract

The invention relates to an absorbable iron-based instrument which comprises an iron-based matrix, a zinc-containing protective layer, a corrosion promoting layer and a drug controlled release layer, the iron-based matrix is provided with an outer wall, an inner wall and a side wall, the zinc-containing protective layer at least covers the outer wall and the inner wall of the iron-based matrix, the corrosion promoting layer completely covers the zinc-containing protective layer, the drug controlled release layer at least partially covers the corrosion promoting layer, both the corrosion promoting layer and the drug controlled release layer contain degradable polymers, the weight-average molecular weight of the degradable polymer in the corrosion promoting layer is greater than that of the degradable polymer in the drug controlled release layer, and a thickness ratio of a portion of the zinc-containing protective layer located on the inner wall to a portion of the corrosion promoting layer located on the inner wall is greater than a thickness ratio of a portion of the zinc-containing protective layer located on the outer wall to a portion of the corrosion promoting layer located on the outer wall. The corrosion behavior of the absorbable iron-based instrument meets the clinical use requirement, and the adverse histological reaction is less or not generated.

Description

technical field [0001] The invention relates to the field of medical devices, in particular to an absorbable iron-based device. Background technique [0002] This section provides background information related to the present disclosure only and is not necessarily prior art. [0003] At present, percutaneous coronary intervention (PCI) technology has become the main treatment for cardiovascular stenosis. Since the first surgery performed by Andreas Gruentzig in 1977, PCI technology has continued to advance, in which intravascular stents have undergone development from bare metal stents (BMS) to drug-eluting stents (DES) to bioabsorbable stents (BRS) innovation. [0004] Bioabsorbable stents are mainly divided into two types according to their materials, one is degradable polymer stents, and the other is corrodible metal stents. Among them, polylactic acid is the most widely studied degradable polymer scaffold material. It has good biocompatibility, and its degradation pr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/07
CPCA61F2/07A61F2210/0004A61F2240/001A61F2310/00017A61F2310/00473A61F2310/0097A61L31/16A61L31/022A61L31/088A61L31/10A61L31/148A61L2420/08A61L31/14A61F2250/0067A61F2/82A61F2250/0031A61F2250/0036A61F2250/0054
Inventor 边东林文娇
Owner BIOTYX MEDICAL (SHENZHEN) CO LTD
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