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Rhodomyrtus tomentosa polyphenol dispersed zinc oxide particles and preparation method and application thereof

A technology of myrtle and nano-zinc oxide, applied in the field of feed additives, can solve the problems of easy agglomeration of ZnO nanoparticles, strict control conditions, harsh experimental conditions, etc., and achieve stable structure, wide application range and balanced antibacterial performance Effect

Inactive Publication Date: 2021-03-30
GUANGZHOU LEADER BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The physical method is to use special pulverization technology to combine physical methods including vapor deposition, mechanical pulverization and heavy ion bombardment. The particle size of these methods is easy to control, but the expensive equipment required limits its wide use; chemical The main methods include sol-gel method, microemulsion method, spray drying method, direct precipitation method, etc. These methods have the disadvantages of harsh experimental conditions, strict control conditions, and the resulting ZnO nanoparticles are prone to agglomeration.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment 1

[0016] Specific Example 1: Preparation of Myrtle Polyphenol-dispersed Zinc Oxide Nanoparticles MZ-1

[0017] (1) Sodium hydroxide solution of myrtle polyphenols: Add 0.5 kg of sodium hydroxide and 5 kg of pre-powdered dried myrtle leaves to 40 kg of pure water in sequence, and ultrasonically extract 2 Hours, suction filtration and separation, the filtrate is the alkali solution containing myrtle polyphenols. The total polyphenol content was determined to be 1.02% by Folin's phenol colorimetric method.

[0018] (2) Preparation of ZnO nanoparticles: 0.5 kg ZnSO 4 .7H 2 O was dispersed in 20 kg of water, stirred thoroughly for 5 minutes to make ZnSO 4 .7H 2 O was completely dissolved, and was added dropwise to the myrtle polyphenol solution in step (1) under stirring at 800 rpm, and the dropwise addition was stopped when the pH reached 10, and the stirring was continued for 1.5 hours under microwave irradiation, and then the above solution was taken out and cooled to After s...

specific Embodiment 2

[0019] Specific Example 2: Preparation of Myrtle Polyphenol-dispersed Zinc Oxide Nanoparticles MZ-2

[0020] (1) Preparation of myrtle polyphenol solution: Add 1 g of pre-powdered dried myrtle leaves to 4,000 g of 60% (V / V) alcohol extract in sequence, and ultrasonically extract at 70°C for 2 hours. Separation by suction filtration, the filtrate is a solution containing myrtle polyphenols. The total polyphenol content was determined to be 1.30% by Folin's phenol colorimetric method.

[0021] (2) Preparation of zinc oxide nanoparticles: 50 g of ZnSO 4 .7H 2 O was dispersed in 2000 ml of water and stirred for 5 minutes to make ZnSO 4 .7H 2 O was completely dissolved, and 5 liters of the myrtle polyphenol solution in step (1) was added dropwise under stirring at 800 rpm. After the dropwise addition, 0.1 mol / L sodium hydroxide aqueous solution was continued to be added dropwise until the pH reached 10. Then continue to stir under microwave irradiation for 1.5 hours, then take...

specific Embodiment 3

[0022] Specific example 3: growth test of weaned piglets of MZ-1 and commercially available common nanometer zinc oxide:

[0023] Purchase a feed-grade nano-zinc oxide product (K-1) on the market, and use a laser particle size analyzer to measure its particle size distribution. The dispersed particle size range of zinc oxide is 40-110nm (99%).

[0024]MZ-1, K-1 and the same piglet diet were made into piglet diets according to the ratio of 400 mg / kg and 1000 mg / kg, and 20 weaned piglets aged 25 days in each group were tested for 24 days. Raised without antibiotics, compared the diarrhea rate and average daily weight gain rate. The test found that whether it is 400mg / kg or 1000 mg / kg, MZ-1 is significantly better than K-1 in terms of anti-diarrhea and growth promotion. Among them, MZ-1, 1000 mg / kg, 0 cases of diarrhea, with an average daily weight gain of 0.44 kg; MZ-1, 0 cases of 400 mg / kg diarrhea, with an average daily weight gain of 0.41 kg; K-1, 1000 mg / kg of diarrhea 3 c...

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Abstract

A rhodomyrtus tomentosa extract dispersed nano-zinc oxide composite antibacterial feed additive material is prepared by a homogeneous precipitation method. Zinc oxide is generated in situ, dispersionis kept under the action of rhodomyrtus tomentosa polyphenol, finally coprecipitation fusion is conducted in the drying process, the nanometer primary dispersion state of zinc oxide is kept, and meanwhile the antibacterial activity of rhodomyrtus tomentosa polyphenol is also kept. Because the two materials both have antibacterial activity, the composite material shows an obvious synergistic effect. The rhodomyrtus tomentosa polyphenol dispersed nano-zinc oxide has good antibacterial performance and is suitable for being used as a feed additive.

Description

technical field [0001] The invention relates to zinc oxide nanoparticles dispersed in myrtle polyphenols and its application in feed, belonging to the field of feed additives. Background technique [0002] Myrtle, a plant of the genus Myrtle in the Myrtaceae family, is widely distributed in the Lingnan region of my country and Southeast Asian countries. As a bactericidal and anti-inflammatory herbal medicine commonly used in the folks of Lingnan and Southeast Asian countries, myrtle has recently been verified by scientists for its antibacterial properties and mechanism of action. The research group of Dr. Qiu Shengxiang from the South China Institute of Botany, Chinese Academy of Sciences has conducted a lot of research on the antibacterial compounds of myrtle and found that its leaves are very rich in phloroglucinol compounds. Gram-positive bacteria such as Staphylococcus aureus have a high antibacterial effect. However, while myrtle plants have outstanding antibacterial ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23K20/20A23K20/22A23K20/10A23K40/00C01G9/02B82Y40/00B82Y30/00
CPCA23K20/30A23K20/22A23K20/10A23K40/00C01G9/02B82Y40/00B82Y30/00C01P2004/64C01P2004/51
Inventor 林劲冬邱声祥陆豫赵丽云余勃陶正国
Owner GUANGZHOU LEADER BIO TECH
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