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Germ-repellent plastic, a gas pathway of a respiratory device containing, and a manufacturing method therefor

A technology for antibacterial plastics and breathing devices, applied in the field of plastics, can solve the problems of technical limitations, reducing the design flexibility of medical breathing device manufacturers, and increasing costs.

Pending Publication Date: 2021-01-22
VINCENT MEDICAL MFG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, existing antimicrobial plastics may also have technical limitations, such as requiring masterbatches to contain the same base polymer backbone as the base plastic
It has been found that the technical limitations described above may reduce design flexibility for medical respiratory device manufacturers
In addition this may also result in an increase in the cost of the masterbatch and / or final product

Method used

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  • Germ-repellent plastic, a gas pathway of a respiratory device containing, and a manufacturing method therefor
  • Germ-repellent plastic, a gas pathway of a respiratory device containing, and a manufacturing method therefor
  • Germ-repellent plastic, a gas pathway of a respiratory device containing, and a manufacturing method therefor

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0063]Preparation of bacterial test inoculum: Escherichia coli ( 8739 TM ) and Staphylococcus aureus ( 6538P TM ).

[0064] According to Japanese Industrial Standards (JIS Z 2801:2000), a test inoculum of bacteria was prepared and counted while culturing. With slight modifications, this JIS was used to test the antimicrobial activity and efficacy against bacteria on the surface of the sample. Please refer to Flowchart 1 to illustrate the process in graphical format with the following explanation:

[0065]

[0066] Flowchart 1 Preparation of test inoculum of bacteria

[0067] 1) Pick out a single bacterial colony from the agar plate (stored in a refrigerator at 4°C), and transfer it to 3 mL of gravy for overnight culture;

[0068] 2) Transfer 300 μL of cultured bacteria to 3 mL of fresh gravy and incubate for about 3-4 hours;

[0069] 3) Harvest bacteria by centrifuging at a speed of 8000rpm for 1-2 minutes (for Escherichia coli, OD600 must be adjusted to 0.6-0.7; f...

Embodiment 1

[0095] A mixture of 8.3 wt% EVA base plastic, 83.3 wt% ethylene / acrylic acid / maleic acid terpolymer intermediate plastic, and 8.3 wt% ceteareth anti-biofouling compound was mixed to form a masterbatch. Specifically, the anti-biofouling compound, EVA base plastic and intermediate plastic were mixed together in a twin-screw extruder whose temperature ranged from 90°C at the front to 190°C at the rear.

[0096] The (main) base plastic is a blend of two ethylene-octene POEs. The weight ratio of masterbatch to base plastic is 1:54. The masterbatch and base plastic were fed into a single-screw extruder whose temperature ranged from 90°C at the front to 235°C at the rear to form the antimicrobial plastic (A). The single-screw extruder extrudes antimicrobial plastic in sheet form.

[0097] Therefore, the percentage by weight in the final antibacterial plastic sheet is: 0.15% EVA base plastic, 1.5% ethylene / acrylic acid / maleic acid terpolymer intermediate plastic, 0.15% ceteareth ant...

Embodiment 2

[0108] Antibacterial plastics (B) and comparative plastics (comparison 2) were prepared according to the method of Example 1, except that the temperature range of the twin-screw extruder was 110° C. at the front to 190° C. at the rear when preparing the masterbatch. When preparing antibacterial plastics, the temperature of the single-screw extruder ranges from 210°C at the front to 235°C at the rear. In addition, these samples were extruded from a single screw extruder to form lengths of tubing rather than sheets as in Example 1.

[0109] A swab test (above) was performed comparing the antimicrobial properties of the antimicrobial plastic (B) and a control plastic (Control 2).

[0110] Example 2 Table 1

[0111] Tube samples with E. coli copy 1 copy 2 copy 3 average Comparative Plastic (Comparison 2) 2.44x 10 3

1.01x 10 4

6.22x 10 3

6.25x 10 3

Antibacterial plastic (B) 3.60x 10 2

3.20x 10 2

1.43x 10 2

2.74x 10 2

...

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Abstract

A germ-repellent plastic for use in a gas pathway of a respiratory device contains an anti-biofouling compound, and a basic plastic. The anti-biofouling compound is optionally selected from the groupof a polyol, a polyether polyol, a polyol derivative, and a combination thereof; or the anti-biofouling compound is selected from the group consisting of a polyether, a poly (ethylene glycol) ether, apolysorbate, and a combination thereof; or the anti-biofouling compound is selected from the group consisting of poly (ethylene glycol) sorbitan monolaurate, poly (ethylene glycol) sorbitan monooleate, poly (ethylene glycol) sorbitol hexaoleate, ceteareth, and a combination thereof. The basic plastic is selected from the group of a blend of a low-density polyethylene polymer and an ethyl vinyl acetate copolymer, a blend of a polypropylene polymer and an ethyl vinyl acetate copolymer, a blend of polyolefin elastomer polymers and a polyvinyl chloride polymer. A method for manufacturing such a germ-repellent plastic, a gas pathway component of a respiratory device containing the germ-repellent plastic, and a respiratory device are also described.

Description

technical field [0001] The invention relates to a plastic, a method of producing the plastic, an air channel of a breathing device and a breathing device comprising the plastic. Background technique [0002] Medical breathing devices made of plastic, especially breathing tube assemblies made of plastic, can be manufactured by various methods, such as extrusion (especially in the case of tubes), injection molding, vacuum forming, etc., as desired. [0003] There are antimicrobial and / or antimicrobial plastics which contain germicidal and microbicidal materials embedded in and / or coated on the plastic. These plastics are designed to kill any bacteria, microbes, etc. that come into contact with the plastic, thereby reducing the chance of infection, transmission, etc. But because regulations on antimicrobial and / or antimicrobial materials vary widely between countries, it has been found that such antimicrobial and / or antimicrobial plastics can be difficult to register for use i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L23/06C08L23/08C08L27/06A61M16/00
CPCC08L27/06C08L23/0869C08L23/0815C08L2205/025C08L2205/035C08L23/06C08L23/12A61M16/06A61M16/16A61M16/0875A61M2205/0205A61M2207/00C08L71/02C08L23/0853C08L2310/00C08K5/04
Inventor 孟文君郭秀娟陈玥颖张明煜符国富朱青修
Owner VINCENT MEDICAL MFG
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