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Pharmaceutical composition as well as preparation method and application thereof

A composition and drug technology, applied in the field of preparation of the pharmaceutical composition, can solve problems such as complex pathogenesis, large side effects of drug treatment, and uneven quality of health products

Active Publication Date: 2021-01-22
HUBEI HONGTUDI MODERN CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These drugs have relatively large side effects, should not be taken for a long time, and need to be used under the guidance of a doctor
Traditional Chinese medicine has a long history of using single proven prescriptions and Chinese patent medicines to treat constipation. Traditional Chinese medicine treatment emphasizes syndrome differentiation and treatment, and uses Tongli to attack herbs such as rhubarb and senna. The effect is remarkable, but it should not be used for a long time, and it is easy to cause dependence
Due to the complicated pathogenesis of constipation, the side effects of drug treatment, and the mixed health products on the market, there are generally problems with inaccurate functions or the addition of laxative ingredients. It is of great significance to develop products with exact functions and less toxic and side effects

Method used

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  • Pharmaceutical composition as well as preparation method and application thereof
  • Pharmaceutical composition as well as preparation method and application thereof
  • Pharmaceutical composition as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Embodiment 1 prescription screening test

[0019] The raw material formula of embodiment 1-6 is shown in table 1.

[0020] The raw material formula table of each embodiment of table 1

[0021]

[0022]

[0023] Dried kombu and puffy sea were crushed into fine powder, then added linseed oil and stirred evenly for the following tests.

[0024] 1. Laxative experiment

[0025] Modeling method: 80 Kunming mice (male, weighing 18-22 g) were randomly divided into 8 groups: blank group, model group, and Example 1-6 groups, with 10 mice in each group. After the mice were grouped, each example group was intragastrically given the corresponding drug at a dose of 2.08g / kg every day, and the blank group and the model group were given distilled water for 14 consecutive days. After the test substance, the mice were fasted without water for 16 hours, the model group and the example group were given compound diphenoxylate (5 mg / kgBW) by intragastric administration, and the blan...

Embodiment 7

[0047] 750g kombu, 50g fat sea, 200g linseed oil

[0048] Take kelp, Panda Dahai, and linseed oil according to the weight ratio, dry the kelp and crush it into a 200-mesh fine powder, add 10 times the weight of Panda Dahai to decoct and extract twice, each time for 1.5 hours, filter, combine the filtrate and concentrate Make a thick paste, then mix the thick paste, linseed oil and kombu micropowder, wet granulate, dry, seal and pack, and sterilize.

[0049] When eating, the granules can be made into a paste with a small amount of boiled water for consumption, or can be melted with a large amount of boiled water for drinking. The main ingredient in this food is kombu, whose powder has poor solubility and strong fishy smell, which is difficult for many consumers to accept, and its application is limited.

[0050] The applicant first referred to a large number of literatures, and screened the single ingredients of natural product deodorizing agents such as hawthorn, vinegar, sal...

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Abstract

The invention discloses a pharmaceutical composition which is prepared from the following raw materials in percentage by weight: 30-80% of kelp, 5-30% of boat-fruited sterculia seeds and 10-40% of linseed oil. The pharmaceutical composition can accelerate small intestine movement, improve the small intestine peristalsis function and promote defecation to relieve constipation, can also reduce the serum TC value and TG value of a high-fat animal model and increase the HDLC value, and has a fat lowering effect. The pharmaceutical composition can be used for treating hyperlipemia and functional constipation on the whole, and is convenient to eat, safe, reliable and good in taste.

Description

technical field [0001] The invention relates to a pharmaceutical composition with lipid-lowering and laxative functions, and also relates to a preparation method and application of the pharmaceutical composition. Background technique [0002] Constipation is a common chronic digestive tract disease, which not only causes symptoms such as abdominal distension, abdominal pain, vomiting, headache, facial acne and freckles, irritability, and lack of energy, but is also associated with hypertension, hyperlipidemia, liver disease, breast cancer, etc. , colorectal cancer, hemorrhoids, anal fissure and other diseases have a great correlation, seriously affecting the patient's mood and quality of life. With the development of society, the improvement of the economy, the advancement of science and technology, and the changes in people's eating and living habits, especially genetically modified foods and deep-processed foods are gradually replacing some pure natural foods, the incidenc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/55A61P3/06A61P1/10A23L33/10A23L33/115
CPCA61K36/03A61K36/185A61K36/55A61P3/06A61P1/10A23L33/10A23L33/115A61K2236/331A61K2236/39A61K2236/15A23V2002/00A61K2300/00A23V2200/32A23V2200/3262Y02A50/30
Inventor 颜春潮聂诗明陈运中徐建中张李瞿彩丽
Owner HUBEI HONGTUDI MODERN CHINESE MEDICINE
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