Contact lens containing diquafosol sodium and preparation method of contact lens

A technology of contact lens and fosol sodium, which is applied in the field of contact lenses containing diquafosol sodium and its preparation, can solve the problems of frequent dosing and achieve a significant slow-release effect

Pending Publication Date: 2021-01-01
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The object of the present invention is to provide a contact lens containing diquafosol sodium and a preparation method thereof. Compared with traditional eye drops, the preparation can increase the residence time of the drug on the ocular surface, achieve sustained release administration, and improve Bioavailability, which solves the problem of frequent administration of traditional eye drops

Method used

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  • Contact lens containing diquafosol sodium and preparation method of contact lens
  • Contact lens containing diquafosol sodium and preparation method of contact lens

Examples

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Effect test

Embodiment 1

[0025] Accurately weigh 10 mg of hydroxyethyl methacrylate, 4 mg of N-vinylpyrrolidone, and 0.3 mg of polyethylene glycol diacrylate, add 9 mL of water, react to form a free radical polymerization solution, and then add 1 mL of 300 mg / mL diquafosol sodium aqueous solution , after stirring evenly, add 12.5 mg of Irgacure 2959, and stir evenly. After the reaction mixture was degassed with nitrogen for 15 minutes, the mixture was poured into a mold, and irradiated with ultraviolet rays at 325 nm for 30 minutes to solidify the gel to obtain the obtained product.

Embodiment 2

[0027] Accurately weigh 10 mg of hydroxyethyl methacrylate, 5 mg of N-vinylpyrrolidine, 0.3 mg of polyethylene glycol diacrylate, add 9 mL of water, react to form a free radical polymerization solution, and then add 300 mg / mL diquafosol sodium aqueous solution 1mL, after stirring evenly, add 12.5mg of Irgacure 2959, and stir evenly. After the reaction mixture was degassed with nitrogen for 15 minutes, the mixture was poured into a mold, and irradiated with ultraviolet rays at 325 nm for 30 minutes to solidify the gel to obtain the obtained product.

Embodiment 3

[0029] Accurately weigh 10 mg of hydroxyethyl methacrylate, 4 mg of N-vinylpyrrolidine, 0.8 mg of polyethylene glycol diacrylate, add 9 mL of water, react to form a free radical polymerization solution, and then add 300 mg / mL diquafosol sodium Aqueous solution 1mL, after stirring evenly, add 12.5mg of Irgacure 2959, stir evenly. After the reaction mixture was degassed with nitrogen for 15 minutes, the mixture was poured into a mold, and irradiated with ultraviolet rays at 325 nm for 30 minutes to solidify the gel to obtain the obtained product.

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Abstract

The invention discloses a contact lens containing diquafosol sodium and a preparation method of the contact lens, and belongs to the technical field of pharmaceutical preparations. Free radical polymerization reaction is conducted after a medicine solution is mixed with a polymer monomer solution, and polymer gel is cured by ultraviolet irradiation, so that the contact lens containing the diquafosol sodium is prepared. Compared with commercially available diquafosol sodium eye drops, the preparation can prolong the release time of medicine, improve the bioavailability of the medicine, reduce the administration frequency and improve the compliance of patients.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a contact lens containing diquafosol sodium and a preparation method thereof. Background technique [0002] Dry eye syndrome, a condition in which the conjunctiva and cornea are not surrounded by a healthy amount or quality of tears, affects more than 50 million people in the United States alone. Dry eye syndrome includes itching and burning of the eye, grittiness, photosensitivity, blurred vision, and inflammation, all of which can seriously affect a patient's quality of life. Patients with dry eyes receive eye drops, lubricants, comfort agents, or artificial tears to increase tear viscosity, slow tear drainage, and increase ocular surface moisture. [0003] Diquafosol Sodium Eye Drops was developed by Santen Pharmaceuticals after obtaining authorization from Inspire Pharmaceuticals. It was first approved in Japan in October 2010 for the treatmen...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K31/675A61K47/34G02C7/04A61P27/02C08J3/075C08F220/20C08F226/10C08F222/14C08F2/48C08L33/14
CPCA61K9/0051A61K9/06A61K31/675A61K47/34G02C7/049A61P27/02C08J3/075C08F220/20C08F2/48C08J2333/14C08F226/10C08F222/1063
Inventor 柯学吴钰颖蒋雯
Owner CHINA PHARM UNIV
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