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Orally disintegrating tablet capable of freshening breath and preparation method thereof

An orally disintegrating tablet and orally disintegrating technology, applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, drug combinations, etc., can solve problems such as easy melting/melting, easy to stick to the inner wall of the oral cavity, etc., to improve oral problems , Prolonged action time, light weight effect

Active Publication Date: 2022-05-13
BEIJING MEDISAN TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because its carrier matrix is ​​colloid (a mixture of Prussian polysaccharide, xanthan gum, carob gum, and carrageenan), it is very easy to stick to the inner wall of the oral cavity after taking it, especially the upper jaw, causing a large amount of menthol to be released locally. Cold, spicy, and even painful; at the same time, the colloidal carrier is easy to melt / melt in a humid or hot environment. The product should be stored in a dry environment at 20-25°C, and it should be used as soon as possible after opening a box (24 pieces / box) Finish
[0007] Therefore, although this product has good fresh breath, eliminates halitosis, antibacterial and bactericidal effects, it still needs to be improved in the sense of use.

Method used

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  • Orally disintegrating tablet capable of freshening breath and preparation method thereof
  • Orally disintegrating tablet capable of freshening breath and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Embodiment 1 can make the preparation of the orally disintegrating tablet of fresh breath

[0042] 1. Formula

[0043] As shown in Table 1 and Table 2, the parts in it represent parts by weight.

[0044] Table 1

[0045] Element Recipe 1 Recipe 2 Recipe 3 Recipe 4 Recipe 5 Thymol 0.8 parts 0.8 parts 0.8 parts 0.8 parts 0.8 parts Methyl salicylate 1 copy 1 copy 1 copy 1 copy 1 copy Eucalyptus oil 1.2 parts 1.2 parts 1.2 parts 1.2 parts 1.2 parts peppermint 15 copies 12 copies 12 copies 22 copies 30 copies copper gluconate 0.7 parts 0.7 parts 0.7 parts 0.7 parts 0.7 parts Mannitol 26 copies 32 copies 32 copies 26 copies 26 copies gelatin 28 copies 28 copies 28 copies 28 copies 28 copies Sucralose 3.5 servings 2.5 servings 1.8 servings 2.5 servings 2.5 servings Fruit green pigment 0.08 parts 0.08 parts 0.08 parts 0.08 parts...

Embodiment 2

[0060] Example 2 Taste Evaluation of Fresh Breath Orally Disintegrating Tablets

[0061] Taking sweetness, coolness, strange taste, residue in the mouth after instant melting, and maintenance time as indicators, 10 people aged 20 to 50 were invited to rate the taste to investigate the taste preferences of the public, with a full score of 10. The scoring table and results are shown in Table 3 and Table 4.

[0062] Table 3 Scoring Form

[0063]

[0064]

[0065] Table 4 Scoring results of each formula

[0066] sweetness cool feeling strange smell the remains maintenance time total score Recipe 1 4.7 2.9 1.5 1.0 3.3 6.9 Recipe 2 3.7 2.3 2.3 1.0 3.0 6.4 Recipe 3 1.5 2.5 2.6 1.0 3.0 5.8 Recipe 4 3.7 3.1 1.1 1.0 4.2 8.6 Recipe 5 3.1 3.3 1.1 1.0 4.8 9.4 Recipe 6 2.7 4.5 1.0 1.0 5.0 8.6 Recipe 7 2.2 4.6 3.6 1.0 5.0 6.1 Recipe 8 3.4 3.4 1.0 1.0 5.0 9.4 Recipe 9 3.5...

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Abstract

The invention discloses an orally disintegrating tablet capable of freshening breath and a preparation method thereof. The orally disintegrating tablet is made of antibacterial essential oil, sulfur precipitant, filler, and binder as raw materials, and is made by freeze-drying process, specifically: the filler, sulfur precipitant, sweetener, and flavoring agent 1. The water-soluble pigment is dissolved in water; the antibacterial essential oil composition and the water-insoluble pigment are added to the above solution; the adhesive is dissolved in water at 50-70°C, cooled to 30°C after complete dissolution, and added to the above solution; Cut with a high-speed shearing homogenizer, degas the emulsion; pour it into a mold; freeze-dry to make an orally disintegrating tablet. The orally disintegrating tablet of the present invention can quickly change breath, continuously suppress bad breath, help to improve oral problems, is easy to store and carry, and is easy to use, and can meet the needs of modern people for improving breath in social situations. At the same time, its active ingredients can help avoid Generate oral problems and improve the health level of consumers.

Description

technical field [0001] The invention relates to an orally disintegrating tablet and a preparation method thereof, in particular to an orally disintegrating tablet capable of freshening breath and a preparation method thereof. The invention belongs to the technical field of food. Background technique [0002] After paying attention to clean appearance, fashionable clothes, and pursuit of physical beauty, modern city people put another emphasis on the smell of the mouth that can reflect the quality and demeanor of modern people. Due to the increased pressure of work and life and the prevalence of fast food, oral bacteria breed, causing disgusting bad breath, causing unnecessary embarrassment to both parties in the conversation. The bad smell in the mouth not only makes you feel uncomfortable, but also affects the atmosphere of normal conversation and brings a lot of inconvenience to the daily life of patients. Oral odor often occurs in people's daily life, which brings a lot...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K47/42A61K36/61A61P1/02A61K31/05A61K31/618
CPCA61K9/0056A61K9/2063A61K31/05A61K36/61A61K31/618A61K36/534A61P1/02A61K2300/00
Inventor 刘荣王宏媛徐佳茗
Owner BEIJING MEDISAN TECH
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