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Multifunctional tissue adhesion cryogel dressing as well as preparation method and application thereof

A multi-functional, crystal gel technology, applied in viscous dressings, dressings, wave energy or particle radiation treatment materials, etc., can solve problems such as poor tissue adhesion, achieve wound healing, excellent free radical scavenging and antibacterial ability, and maintain The effect of wound moisture

Active Publication Date: 2020-11-10
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In order to overcome the shortcomings of the above-mentioned prior art, the object of the present invention is to provide a multifunctional tissue-adhesive crystal gel dressing and its preparation method and application, so as to solve the technical problem of poor tissue adhesion of existing crystal gel hemostatic materials

Method used

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  • Multifunctional tissue adhesion cryogel dressing as well as preparation method and application thereof
  • Multifunctional tissue adhesion cryogel dressing as well as preparation method and application thereof
  • Multifunctional tissue adhesion cryogel dressing as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Preparation of multifunctional tissue-adhesive crystal gel dressing:

[0050] S1: Dissolving quaternized chitosan (QCS) in deionized water to prepare a QCS mother liquor with a mass percentage of 2.5%;

[0051] Dopamine (DA) was dissolved in deionized water to prepare a 18% DA mother liquor by mass percent;

[0052] Sodium periodate (NaIO 4 , Sigma-Aldrich) was dissolved in deionized water to prepare NaIO with a mass percentage of 6.768%. 4 Mother liquor;

[0053] The above QCS mother liquor, DA mother liquor and NaIO 4 The mother liquor was placed in an ice-water bath at 0°C for 1-2 hours, fully pre-cooled.

[0054] S2: Prepare 5 beakers, add 16mL of pre-cooled QCS mother liquor into each beaker, and add 0.056mL, 0.111mL, 0.222mL, 0.333mL and 0.444mL of pre-cooled DA mother liquor into the above 5 beakers. After mixing completely, add 0.168mL, 0.333mL, 0.666mL, 0.999mL and 1.332mL of NaIO to the 5 beakers in the above order 4 Mother liquor (DA and NaIO 4 The mo...

Embodiment 2

[0058] The difference from Example 1 is that the quaternized chitosan (QCS) in S1 is replaced with carboxymethyl chitosan (CMCS).

Embodiment 3

[0060] The difference from Example 1 is that the quaternized chitosan (QCS) in S1 is replaced with carboxyethyl chitosan (CEC).

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Abstract

The invention discloses a multifunctional tissue adhesion cryogel dressing as well as a preparation method and application thereof. The multifunctional tissue adhesion cryogel dressing is characterized in that amino-containing polysaccharide and a polysaccharide derivative with blood coagulation promoting capability are used as base materials, and polydopamine formed by dopamine oxidative polymerization is used for crosslinking the amino-containing polysaccharide and the polysaccharide derivative in a cryogel system. so that the hemostatic and wound healing promoting properties of the cryogelcan be further enhanced, and the cryogel is endowed with good oxidation resistance and good photo-thermal properties. A hemostatic adhesive tape has good biocompatibility, bacterium resistance, oxidation resistance, tissue adhesion and other properties, and has better blood cell and platelet adhesion, enrichment, activation and blood coagulation capabilities than medical gauze and gelatin sponge.The multifunctional tissue adhesion cryogel dressing is suitable for hemostasis of various different types of human wounds.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and relates to a multifunctional tissue-adhesive gel dressing and a preparation method and application thereof. Background technique [0002] Bleeding control in severe trauma remains a clinical global problem. Uncontrolled bleeding can greatly increase the risk of death for patients on the battlefield, in daily life emergencies, and even in hospital settings, and is now worldwide. Every year 5.8 million people die from uncontrolled bleeding. Traditional and widely used hemostatic materials, including gauze, gelatin sponge, and bandages, can be used to seal the wound by pressing or bandaging the wound site to achieve rapid hemostasis. However, its ability to stop bleeding is extremely weakened in the absence of compression. Therefore, they are not suitable for hemostasis of wounds that are not easy to press or bandage, such as irregular long strip wounds and the like. Moreover, th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00A61L15/28A61L15/44A61L15/46A61L15/20A61L15/18A61L15/42A61K41/00A61K9/06A61P31/04A61P31/02A61P17/02A61P7/04A61P39/06A61F13/02C08G73/06
CPCA61F13/0206A61K9/06A61K41/0052A61L15/18A61L15/20A61L15/28A61L15/42A61L15/44A61L15/46A61L26/0004A61L26/0023A61L26/0061A61L26/0066A61L26/008A61L26/0085A61L26/009A61L2300/236A61L2300/404A61L2300/412A61L2300/418A61L2400/04A61P7/04A61P17/02A61P31/02A61P31/04A61P39/06C08G73/0672C08L5/08C08L5/04
Inventor 郭保林李勐梁永平
Owner XI AN JIAOTONG UNIV
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