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Continuous production process of beta-alanine

A production process, alanine technology, applied in the field of β-alanine, can solve problems such as large heat release, complicated operation, and flushing phenomenon, and achieve high mass transfer and heat transfer efficiency, high resource utilization, and avoid flushing The effect of material flying temperature

Inactive Publication Date: 2020-06-26
DALIAN WONDERSUN BIOCHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Its disadvantages are: 1) the kettle reaction is adopted, the heat released in the reaction process is huge, there is a safety hazard caused by a cooling failure, and a large amount of ammonia gas is generated at the same time, which is prone to flushing under low vacuum; 2 ) The reaction time is long, and β-aminopropionitrile is prone to side reactions such as polymerization, which not only produces difficult-to-separate by-products, but also brings color groups, so that the product feed liquid needs to be decolorized, and the operation is complicated; 3) adding acid It is difficult to separate the inorganic salts produced from β-alanine at one time, and the crude product of β-alanine needs multiple crystallization and purification to obtain qualified products

Method used

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  • Continuous production process of beta-alanine

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Effect test

Embodiment 1

[0027] β-aminopropionitrile and liquid caustic soda with a concentration of 22% are passed into the preheating pipeline with a mixing ratio of 1:2.3 (v / v) through metering pumps respectively, and β-aminopropionitrile and liquid caustic soda are respectively preheated to 80 ℃, then the raw material feed liquid enters the microchannel reactor for hydrolysis reaction, the microchannel reactor includes a star-shaped reactor and a pipeline reactor connected in sequence, the reaction temperature is 150 ℃, the reaction time is 90s, and the reaction pressure is 1.5MPa. After the completion, the reaction feed liquid containing β-alanine sodium, ammonia gas and a small amount of sodium hydroxide enters the high-temperature atmospheric tray distillation deammoniation system, and the ammonia gas drives the feed liquid self-circulation at a temperature of 105 ° C, while the ammonia gas Separated from the water vapor through the tray, the ammonia gas is recovered, and the water gas is return...

Embodiment 2

[0029] Adopt the production method of example 1, difference is that use concentration is the liquid caustic soda of 33%, the mixing ratio of β-aminopropionitrile and liquid caustic soda is 1:1.5 (v / v), 130 ℃ of reaction temperature, 40s of reaction time, reaction Pressure 1.0MPa. The product yield is 96%, and the product purity is 99.7%.

Embodiment 3

[0031] Adopting the production method of Example 1, the difference is that using a concentration of 40% liquid caustic soda, the mixing ratio of β-aminopropionitrile and liquid caustic soda is 1:1 (v / v), the reaction temperature is 100 ° C, the reaction time is 20s, and the reaction Pressure 0.2MPa. The product yield is 95.4%, and the product purity is 99.6%.

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Abstract

The invention belongs to the technical field of beta-alanine, and relates to a continuous production process of beta-alanine. The method comprises the following steps: carrying out instantaneous hydrolysis reaction on the raw material beta-aminopropionitrile and liquid caustic soda through a micro-channel reactor under the conditions of high temperature and high pressure to obtain beta-sodium alanine-containing reaction feed liquid, then removing ammonia gas through a deamination system, exchanging sodium ions through an ion exchange system, and subjecting the exchanged beta-alanine aqueous solution to concentration crystallization to obtain beta-alanine, thus realizing continuous production from feeding to crystallization. According to the method, the reaction time is short, the side reaction occurrence probability is low, the product purity reaches 99.5% or above, and the yield reaches 95% or above; the whole system realizes automatic continuous production, is high in resource utilization rate, saves energy and reduces consumption.

Description

technical field [0001] The invention belongs to the technical field of beta-alanine, and in particular relates to a continuous production process of beta-alanine. Background technique [0002] β-alanine, that is, 3-aminopropionic acid, is a natural β-type amino acid, which can be used to synthesize calcium pantothenate, carnosine, sodium pamidronate, balsalazide, etc., and is used in medicine, feed, food and other fields widely. [0003] At present, it is mainly produced by chemical methods in industry, and there are also reports in the literature that it is synthesized by biocatalytic methods. The routes of chemical synthesis are mainly acrylic acid route, succinimide route and β-aminopropionitrile route. The acrylic acid route needs to be carried out under high temperature and high pressure conditions, and at the same time, by-products mainly composed of 3,3-iminodipropionic acid will be generated, which will affect product quality; the raw material cost of the succinimi...

Claims

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Application Information

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IPC IPC(8): C07C227/02C07C227/40C07C227/18C07C227/42C07C229/08
CPCC07C227/02C07C227/40C07C227/18C07C227/42
Inventor 曾伟滕坤杜大鹏于淼刘福阳
Owner DALIAN WONDERSUN BIOCHEM TECH
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