Preparation method and application of silicate long afterglow probe

Abstract

The invention discloses a preparation method and an application of a silicate long afterglow probe. Mesoporous silicon dioxide is used as a template, zinc nitrate, gallium nitrate, germanium nitrate,ytterbium nitrate, chromic nitrate and erbium nitrate are used as doped metal raw materials, the doped metal raw materials are dissolved in water and uniformly mixed, the mixture is dropwise added into the mesoporous silicon dioxide, roasting is performed at high temperature, and a pre-product is obtained after roasting is finished; then, functional modification is performed on the surface of thepre-product, and hydroxylation, amination and PEG modification are sequentially performed to obtain a modified pre-product; and finally, a photosensitizer silicon dichloride phthalocyanine is loaded to obtain the silicate long afterglow probe. The silicate long-afterglow probe has good biological safety, after caudal vein injection and under X-ray irradiation, a tumor area is effectively enriched,deep in-situ tumor imaging is achieved, in-situ tumor cells are seriously killed, and finally diagnosis and treatment integration of the silicate long-afterglow probe on deep tumors is achieved.

Description

technical field [0001] The invention belongs to the technical field of in situ treatment and diagnosis of liver cancer, and in particular relates to a preparation method and application of a silicate long afterglow probe. Background technique [0002] Cancer, as one of the main threats to human life and health, has been increasing in incidence and mortality in recent decades, and has become a major disease that takes human life. Among them, liver cancer is called "the king of cancer" in my country, and liver cancer is also known as the fifth most common cancer in men and the ninth most common cancer in women in the world; more than half of the new cases in the world every year occur in my country. Liver cancer has become a major disease that affects the life and health of our people and a major health burden for society. Therefore, the effective prevention, diagnosis and treatment of liver cancer are the top priority of biomedical research. At present, the main effective me...

AI Technical Summary

Problems solved by technology

However, long-lasting luminescent materials also have certain limitations, that is, the excitation light source is usually a high-energy ultraviolet irradiation material to achieve afterglow luminescence. The biggest limitation of ultraviolet light in biomedical imaging is that the penetration depth of the light source is too shallow to perform deep imaging

In recent years, researchers have used near-infrared light as an excitation light source to overcome the problem of penetration depth, but the energy of near-infrared light is not enough to achieve good afterglow luminescence, and imaging can only be achieved in a short time

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