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High-plasticity degradable LiZn4-X intermetallic compound and preparing method thereof

An intermetallic compound, lizn4-x technology, applied in the field of design and preparation of biodegradable medical materials, can solve the problems of prolonging the recovery period, aggravating the economic and psychological burden of patients, and achieving the promotion of precipitation and recrystallization, and enhanced plasticity , good plastic effect

Active Publication Date: 2020-05-19
北京尚宁科智医疗器械有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the early clinical application, the commonly used implant materials such as vascular stents and bone nails and plates for the treatment of the above diseases are mainly biologically inert materials such as stainless steel, nickel-titanium, and cobalt-chromium alloys, but the above materials will remain in the human body for a long time after long-term implantation Detention, the vascular stent has problems such as thrombosis, new atherosclerosis or restenosis after the operation is cured, while the orthopedic implant needs a second operation to remove it, which further prolongs the recovery period and increases the financial and psychological burden of the patient

Method used

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  • High-plasticity degradable LiZn4-X intermetallic compound and preparing method thereof
  • High-plasticity degradable LiZn4-X intermetallic compound and preparing method thereof
  • High-plasticity degradable LiZn4-X intermetallic compound and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Example 1: LiZn 4 - Preparation and performance testing of intermetallic compounds.

[0036] The biodegradable LiZn 4 The mass percentage of each chemical element in the -X intermetallic compound is shown in Table 1-1, and the balance is β-LiZn 4 . The preparation process of the intermetallic compound is high temperature homogenization treatment→rolling or extrusion→low temperature aging.

[0037] Homogenization treatment: place the intermetallic compound ingot in a box-type heating and sintering furnace KSL-1400X, raise the temperature to 250°C at a rate of 10°C / min, and keep it for 2 hours; then raise the temperature to 350°C at a rate of 1°C / min ℃, keep warm for 2 hours and then quench in water at room temperature. Obtain the microstructure multi-level structure metallographic photograph of invention example intermetallic compound 1 as figure 1 As shown, the intermetallic compound is composed of coarse grains, and the intragranular is Zn+β-LiZn 4 Lamellar struc...

Embodiment 2

[0051] Example 2: LiZn 4 -X 1 -X 2 Preparation and property testing of intermetallic compounds.

[0052] The biodegradable LiZn 4 -X 1 -X 2 The mass percentage of each chemical element in the intermetallic compound is shown in Table 2-1, and the balance is β-LiZn 4 . The preparation process of the intermetallic compound is high temperature homogenization treatment→extrusion or rolling→low temperature aging treatment. Melting, homogenization heat treatment, extrusion, rolling and aging treatment are carried out according to the method provided in Example 1. Modified LiZn 4 -X 1 -X 2 The microstructure of intermetallic compounds after low-temperature aging is composed of grains with a size of 5-30 μm, and the grains are composed of Zn+β-LiZn 4 It is composed of lamellar structure, and the distance between the lamellar layers is 0.3-0.7 μm. In addition, nano-scale / micro-scale precipitated phases formed by added elements are also precipitated at the intragranular and gra...

Embodiment 3

[0059] Example 3: LiZn 4 -X 1 -X 2 -X 3 Preparation and property testing of intermetallic compounds.

[0060] The biodegradable LiZn 4 -X 1 -X 2 -X 3 The mass percentage of each chemical element in the intermetallic compound is shown in Table 3-1, and the balance is β-LiZn 4 . The preparation process of the intermetallic compound is high temperature homogenization treatment→extrusion or rolling→low temperature aging treatment. Melting, homogenization heat treatment, extrusion, rolling and aging treatment are carried out according to the method provided in Example 1. Modified LiZn 4 -X 1 -X 2 -X 3 The microstructure of the intermetallic compound after homogenization heat treatment is composed of grains with a size of 5-30 μm, and the grain is composed of Zn+β-LiZn 4 It is composed of lamellar structure, and the spacing of the lamellar layers is 0.2-0.4 μm. In addition, nano-scale / micro-scale precipitated phases formed by added elements are also precipitated at the ...

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Abstract

The invention discloses a high-plasticity degradable LiZn4-X intermetallic compound and a preparing method thereof. An X element is one or multiple of Cu, Mg, Ca, Sr, Mn, Fe, Ag, Co, Cr, Ti, Sn, Si, Se or Ge, and the balance is a beta-LiZn4 phase. Through a series of machining processes of vacuum melting preparing, heat treatment, plastic deforming and low-temperature aging, the intermetallic compound is modified, an alloy is subjected to high-temperature heat treatment, and is formed by a polycrystal and transgranular Zn+beta-LiZn4 lamellar structure multi-stage structure, the intermetallic compound is uniform in structure, the room-temperature tensile yield strength of the obtained intermetallic compound is 200 to 500 MPa, the tensile strength is 450 to 800 MPa, the ductility is 18 to 40%, the room-temperature compression yield strength is 500 to 800 MPa, the compressive strength is 1000 to 2000 MPa, the ductility is 15 to 45%, in simulated body fluid, degrading is uniform, the degrading rate is 0.008 to 0.5mm / y, contained elements are biosafety elements, poisonousness of L929 osteogenesis fiber cells and MG63 cells is lower than 2 levels, and use needs of multiple human implantable device materials can be met. The LiZn4-X intermetallic compound is excellent in property, uniform in degrading and good in biocompatibility.

Description

technical field [0001] The invention relates to the design and preparation method of biodegradable medical materials, specifically a kind of highly plastic degradable LiZn 4 -X intermetallic compound and its preparation method. [0002] technical background [0003] Nowadays, the incidence of cardiovascular disease is increasing year by year with the improvement of people's living standards, and it has become the number one killer of non-communicable diseases worldwide. According to statistics from the World Health Organization, about 1.7 million patients died of cardiovascular diseases in 2008, and the number of deaths is expected to rise to 2.5 million in 2030. Secondly, with the further expansion of the aging trend worldwide, orthopedic diseases, mainly degenerative diseases of bone tissue and sports injuries, are also increasing day by day. In the early clinical application, the commonly used implant materials such as vascular stents and bone nails and plates for the tr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C22C18/00C22F1/16
CPCC22C18/00C22F1/165
Inventor 王鲁宁李祯石章智
Owner 北京尚宁科智医疗器械有限公司
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