Application of exenatide to preparation of medicines for treating ocular ischemia diseases and improving ocular blood circulation in eye drip way

A technology of exenatide and drugs, which is applied in the field of medicine to achieve the effect of reducing eye blood supply damage, reducing fear, and high local concentration

Pending Publication Date: 2020-05-19
EYE & ENT HOSPITAL SHANGHAI MEDICAL SCHOOL FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] There is no report about the application of exenatide of the present invention in the preparation of eye drops to treat ocular ischemic diseases and improve ocular blood circulation.

Method used

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  • Application of exenatide to preparation of medicines for treating ocular ischemia diseases and improving ocular blood circulation in eye drip way
  • Application of exenatide to preparation of medicines for treating ocular ischemia diseases and improving ocular blood circulation in eye drip way
  • Application of exenatide to preparation of medicines for treating ocular ischemia diseases and improving ocular blood circulation in eye drip way

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Embodiment 1

[0050] Embodiment 1 Animal experiment

[0051] 1 Experimental materials

[0052] Drug selection Exendin-4 and norepinephrine (NA), were purchased from MedChemExpress Company (USA). Animals were adult male Sprague Dawley (SD) clean grade rats purchased from Shanghai Xipuer-Bicai Experimental Animal Co., Ltd., weighing 200-250 g, kept at room temperature (22-25 degrees Celsius) with sufficient food and drinking water. All animal experiment procedures and operations were in compliance with ARVO's specifications for the care and use of experimental animals, and were approved by the Ethics Committee of the Eye, Ear, Nose and Throat Hospital Affiliated to Fudan University.

[0053] 2 Experimental methods

[0054] 2.1 Selection of organization

[0055] SD rats were anesthetized by intraperitoneal injection of 10% chloral hydrate at a dose of 0.4ml / 100g body weight. After the rats were deeply anesthetized, oxybucaine eye drops were applied locally for superficial anesthesia, and th...

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Abstract

The invention relates to the technical field of medicines, in particular to application of exenatide to preparation of medicines for treating ocular ischemia diseases and improving ocular blood circulation in an eye drip way. The exenatide can be used for treating the ocular ischemia diseases such as onset of acute glaucoma and improving the ocular blood circulation . According to the applicationdisclosed by the invention, through building an acute ischemia reperfusion model and simulating damage of the onset of the acute glaucoma, findings prove that an eye drop preparation of Exendin-4 canimprove a retinal vascular endothelial function, dilating retinal capillary and recovering fundus blood circulation, so that the damage to the fundus blood supply caused by the ocular ischemia diseases such as acute glaucoma can be effectively alleviated, and simultaneously, the findings prove that a new medicine dosage form (eye drop preparation) can achieve an effective local action under the premise of avoiding systemic action. The exenatide disclosed by the invention can be used for treating deficiency of the fundus blood supply such as the acute glaucoma, retinopathy of prematurity and retinal vascular occlusion diseases, and thus, the visual function is saved.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of exenatide in the preparation of eye drops for treating ocular ischemic diseases and improving ocular blood circulation. Background technique [0002] The fundus retina has a great demand for blood oxygen supply. Efficient supply ensures the normal operation of fundus optic nerve metabolism, and the reduction of retinal blood flow often leads to damage of optic nerve cells. [1] . Ischemia-reperfusion can exist in a variety of intraocular disease states, including acute glaucoma attack, retinopathy of prematurity, retinal vascular occlusive disease, etc. [2] . Among them, in patients with acute angle-closure glaucoma attacks, their intraocular pressure often rises sharply, even reaching above 60mmHg. At this time, the fundus blood flow is significantly reduced. . However, when the intraocular pressure is reduced and the blood supply is restored by means of p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/22A61K9/08A61P27/02A61P27/06
CPCA61K38/22A61K9/0048A61K9/08A61P27/02A61P27/06
Inventor 孔祥梅翟如仪许欢
Owner EYE & ENT HOSPITAL SHANGHAI MEDICAL SCHOOL FUDAN UNIV
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