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Application of Piceatannol 3'-O-glucoside in preparation of product for treating and/or preventing respiratory diseases

A technology for respiratory diseases and trizaperoside, which is applied in the field of application of trizaperoside in the preparation of products for the treatment and/or prevention of respiratory diseases, can solve problems such as unseen application reports, and achieve good market prospects and growth The effect of excretion amount and anti-inflammatory effect

Pending Publication Date: 2020-04-14
KPC PHARM INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The prior art shows that stilbeneside has the activity of preventing and treating ischemic cardiovascular and cerebrovascular diseases, antidepressant and improving microcirculation, but there is no report of its use in drugs for "cough, phlegm, asthma"

Method used

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  • Application of Piceatannol 3'-O-glucoside in preparation of product for treating and/or preventing respiratory diseases
  • Application of Piceatannol 3'-O-glucoside in preparation of product for treating and/or preventing respiratory diseases
  • Application of Piceatannol 3'-O-glucoside in preparation of product for treating and/or preventing respiratory diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] 1. Test material

[0033] 1.1 Animals

[0034] SPF grade ICR mice (weight: 20-24g) and guinea pigs (weight: 250-280g) are male and female, provided by the laboratory animal laboratory of Kunming Pharmaceutical Group Co., Ltd., production license: SCXK (Dian) K2014-0001 ;Mice are kept in IVC animal laboratory, guinea pigs are kept in normal-grade animal room, temperature is 20-26°C, humidity is 40%-70%, lighting is 12h: 12h alternating light and dark, illumination is 150-300lx, noise ≤60dB, used for experimental animals License: SYXK (Dian) K2014-0001, issuing unit: Kunming Science and Technology Bureau.

[0035] 1.2 Drugs and reagents

[0036] Tristilbene, batch number 20160301, the raw material was provided by the Pharmaceutical Research Institute of Kunming Pharmaceutical Group. Codeine Phosphate Tablets: Sinopharm Group Industry Co., Ltd., batch number 20180817. Ambroxol hydrochloride tablets: Sandoz (China) Pharmaceutical Co., Ltd., batch number FP264. Aminophy...

Embodiment 2

[0081] The tablet of this example consists of the following components: 50 g of tristilbene, 100 g of microcrystalline cellulose, 50 g of pregelatinized starch, 40 g of low-substituted hydroxypropylmethyl cellulose, and 1 g of micropowdered silica gel.

[0082] The above-mentioned raw materials were mixed, and trizaperine tablets were prepared according to conventional methods.

Embodiment 3

[0084] The capsule of this embodiment is composed of the following components: 25 g of tristilbene, 80 g of microcrystalline cellulose, 10 g of lactose, an appropriate amount of povidone K-30, and 2 g of magnesium stearate.

[0085] Mix the above-mentioned raw materials, and prepare tristilbene capsules according to conventional methods.

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Abstract

The invention belongs to the field of biological pharmacy, and discloses application of Piceatannol 3'-O-glucoside in preparation of a product for treating and / or preventing respiratory diseases, particularly application of Piceatannol 3'-O-glucoside in preparation of a product for treating and / or preventing respiratory diseases with cough, and / or expectoration and / or asthma symptoms. Experimentalresults show that the Piceatannol 3'-O-glucoside can obviously reduce the frequency of mouse cough caused by stronger ammonia water, obviously reduce the frequency of citric acid-induced cough of guinea pigs and prolong the cough incubation period, obviously increase the excretion amount of tracheal phenol red in mice, obviously prolong the latency time of guinea pig asthma caused by histamine phosphate and acetylcholine chloride, and obviously inhibit the mouse ear swelling degree. Test results show that the Piceatannol 3'-O-glucoside has obvious curative effects of relieving a cough, eliminating phlegm, relieving asthma and resisting inflammation, has a potential treatment effect on respiratory diseases, and has a wide clinical application prospect.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the application of trizaperidin in the preparation of products for the treatment and / or prevention of respiratory diseases, especially having obvious curative effect on coughing up phlegm and asthma. Background technique [0002] Respiratory system disease is a common and frequently-occurring disease. The main lesions are in the trachea, bronchi, lungs and chest cavity. After the onset, it often manifests as coughing, panting, shortness of breath, and excessive phlegm, which seriously affects the health of the patient and even endangers the life of the patient. . The death rate in the city is the third, while in the countryside it is the first. What should be paid more attention to is that due to air pollution, smoking, population aging and other factors, chronic obstructive pulmonary disease (referred to as COPD, including chronic bronchitis, emphysema, pulmonary h...

Claims

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Application Information

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IPC IPC(8): A61K31/7034A61P11/00A61P11/14A61P11/06A61P11/10A23L33/105
CPCA61K31/7034A61P11/00A61P11/14A61P11/06A61P11/10A23L33/105A23V2002/00A23V2200/314A23V2250/21
Inventor 刘一丹杨旭娟黄茜黄青赵水仙刘国光尚建华
Owner KPC PHARM INC
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