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Method for acquiring active surface layer generating active free radical and group on surface of inorganic medical equipment

An active surface layer, medical device technology, applied in pharmaceutical formulations, coatings, pharmaceutical sciences, etc., can solve problems such as insufficient biocompatibility of implants, no surface free radicals and active groups, osteolysis, etc. Achieve the effect of improving biocompatibility, not easy to deform, and low cost of preparation

Inactive Publication Date: 2019-08-30
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] 316L stainless steel, medical cobalt alloy, zirconia and other medical metals and functional ceramic materials have good mechanical properties and biocompatibility, and are often used to prepare implantable medical devices and artificial organs such as vascular stents, artificial heart valves, artificial joints, etc. ; however, these implants are not biocompatible enough and prone to coagulation, infection, osteolysis, etc. in patients
Patent CN 103561790 A (catheter balloon coated with rapamycin and shellac) also relates to the shellac coating, but it uses the coating containing rapamycin and shellac for the catheter balloon, and Does not involve plasma technology treatment to generate surface free radicals and active groups

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Adopt dip-coating method to prepare shellac coating on metal material stainless steel surface, adopt nitrogen plasma to treat coating again, wherein sample platform adds pulse negative voltage, makes the preparation method that surface produces active free radical and reactive group, comprises the following steps:

[0018] A. After ultrasonic cleaning and drying of stainless steel metal medical instruments with propanol and ethanol, take them out and soak them in shellac solution (100 mg / ml concentration) with ethanol as solvent, then take them out and dry them.

[0019] B. Put shellac-coated metal and inorganic medical instruments on the sample stage of the vacuum chamber of the magnetron sputtering equipment, and place the metal grid 5 cm above the sample to attract ions to bombard the sample; pump the vacuum chamber Vacuum to 2.0×10 -3 Pa; nitrogen gas was introduced into the vacuum chamber until the pressure was 2.0Pa; inductively coupled radio frequency (13.56MHz) ...

Embodiment 2

[0021] Prepare shellac and RSNO (NO donor) coatings on the surface of metal stainless steel by dip coating, and then use nitrogen plasma to treat the coating, in which the sample stage is applied with a pulsed negative voltage to generate active free radicals and reactive groups on the surface. The preparation method comprises the following steps:

[0022] A, stainless steel metal medical instrument adopts propanol, ethanol after ultrasonic cleaning and drying, take out and put into ethanol and soak in the mixed solution of shellac (concentration is 100mg / ml) and RSNO (concentration is 3mg / ml) of solvent for 1 minute, Remove to dry.

[0023] B. Put the above instruments on the sample stage of the vacuum chamber of the magnetron sputtering equipment, place the metal grid 5 cm above the sample to attract ions to bombard the sample; vacuumize the vacuum chamber to 2.0×10 -3 Pa; nitrogen gas was introduced into the vacuum chamber until the pressure was 2.0Pa; inductively coupled ...

Embodiment 3

[0025] Prepare the shellac coating on the surface of the hydroxyapatite inorganic material by dip coating, and then use oxygen plasma to treat the coating, wherein the sample stage is applied with a pulsed negative voltage to make the surface generate active free radicals and active groups. The preparation method includes: The following steps:

[0026] A. After the hydroxyapatite medical device is ultrasonically cleaned and dried with propanol and ethanol, take it out and put it into a shellac solution (concentration: 100mg / ml) with ethanol as the solvent, soak for 1 minute, take it out and dry it.

[0027] B. Put the above-treated instruments on the sample stage of the vacuum chamber of the magnetron sputtering equipment after drying, and place the metal grid 5 cm in front of the sample to attract ions to bombard the sample; vacuumize the vacuum chamber to 2.0 ×10 -3 Pa; Introduce oxygen into the vacuum chamber until the pressure is 2.0Pa; use inductively coupled radio frequ...

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Abstract

The invention discloses a method for acquiring an active surface layer generating an active free radical and group on the surface of inorganic medical equipment. The surface base of the inorganic medical equipment is coated with shellac and is treated by the plasma technique, so that the active surface layer which can generate the active free radical and active group can be acquired on the surfaceof the medical equipment. A shellac coating and a coating prepared from the shellac and optionally other components can be prepared on the surface of metal and the inorganic medical equipment by adopting techniques of dip-coating, spray-coating, spin-coating, splashing and the like, and the active free radical and group can be generated on the surface of the shellac coating which is treated by adopting oxygen, argon, air and other plasmas. The method can be used for further covalent grafting of protein or antibody and the like, so that the biocompatibility of the surface of a biological material and medical equipment can be improved. The method is safe and nontoxic, and has the characteristics of good biocompatibility, simple operation, low preparation cost, simple film-forming process, low price and substrate deformation prevention.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a method for preparing shellac coatings on inorganic surfaces such as metals and functional ceramic substrates and using plasma technology to generate free radicals and active groups on the surfaces. Background technique [0002] 316L stainless steel, medical cobalt alloy, zirconia and other medical metals and functional ceramic materials have good mechanical properties and biocompatibility, and are often used to prepare implantable medical devices and artificial organs such as vascular stents, artificial heart valves, artificial joints, etc. ; However, these implants are not biocompatible enough, and they are prone to coagulation, infection, osteolysis and other problems in patients. The immobilization of proteins, peptides or antibodies on the surface can be used to obtain multifunctional surfaces of medical devices, which can improve the biocompatibility of these ...

Claims

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Application Information

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IPC IPC(8): A61L31/10A61L31/14A61L31/02A61L27/34A61L27/50A61L27/10A61L27/06A61L27/04A61L27/12
CPCA61L27/04A61L27/06A61L27/10A61L27/12A61L27/34A61L27/50A61L31/022A61L31/026A61L31/028A61L31/10A61L31/14A61L2400/18A61L2420/02A61L2420/08A61L2430/20A61L2430/24C08L93/02
Inventor 景凤娟任倩覃利娜黄斌谢东冷永祥黄楠
Owner SOUTHWEST JIAOTONG UNIV
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