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Laser interference nanolithography system for one-step titanium alloy implant surface texturing and modification

A laser interference and nano-lithography technology, which is applied in the field of laser interference nano-lithography system for one-step texture modification on the surface of titanium alloy implants, can solve the lack of osteoinductive effect, failure and complications, and the ability to combine with surrounding bone tissue Poor problems, to achieve the effect of enhancing titanium alloy implant-osseointegration ability, changing roughness and biocompatibility, and improving biomechanical bonding performance

Inactive Publication Date: 2017-06-13
CHANGCHUN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] At present, implant placement has achieved certain results in clinical practice, but there are still risks of failure and complications, such as implant loosening, peri-implant inflammation, peri-implant bone loss and allergic reactions, etc.
The main cause of implant failure is that the metal implant cannot achieve good bone ingrowth with the bone tissue around the implant site.
In the mid-1950s, it was found that titanium metal has excellent biocompatibility and is cheap, so titanium alloys are widely used as implant materials, but there are still some problems in the clinical application of titanium alloy implants, such as biological Poor activity, lack of osteoinductive effect, poor ability to combine with surrounding bone tissue, release of metal ions, long bone ingrowth time and poor corrosion resistance, etc.
Therefore, it is not reliable to measure surface roughness simply by Ra value

Method used

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  • Laser interference nanolithography system for one-step titanium alloy implant surface texturing and modification
  • Laser interference nanolithography system for one-step titanium alloy implant surface texturing and modification
  • Laser interference nanolithography system for one-step titanium alloy implant surface texturing and modification

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Experimental program
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Effect test

Embodiment 1

[0021] Using Matlab to simulate the three-beam interference pattern, theoretical analysis and experimental research modulated multi-beam interference to obtain a multi-period micro-nano hybrid structure. Based on the analysis of electromagnetic wave theory, a mathematical physical model is established, and the combination of software simulation and actual lithography is used to analyze the interference mechanism of the modulation phenomenon under specific parameter conditions, and the micron-level modulation period consistent with the simulated structure is obtained by precisely controlling the pulsed laser energy. and micro-nano hybrid structures with nanoscale feature sizes. Based on the results of theoretical and experimental analysis, a three-beam interference lithography system is built, such as figure 1 shown. Laser 1 emits a beam of laser light that passes through high reflection mirror 2, high reflection mirror 3, beam splitter 4 and high reflection mirror 5, and reac...

Embodiment 2

[0023] First, use Matlab to simulate the two-beam interference pattern, theoretically analyze and experiment to study the interaction mechanism between the interference light and the material, determine the lithography threshold of the material and realize quantitative nano-lithography. Study the interference lithography threshold of a given material relative to a given laser in a specific environment, and establish mathematical and physical models such as single temperature, double temperature, and molecular dynamics to study the non-equilibrium heat conduction process between interference light and solid materials. The consistency of the interference lithography pattern with the simulated structure is ensured by precise control of the pulsed laser energy. Based on the results of theoretical and experimental analysis, a two-beam interference lithography system is built, such as image 3 shown. Laser 1 emits a beam of laser light that passes through high reflection mirror 2, ...

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Abstract

The invention discloses a laser interference nanolithography system for one-step titanium alloy implant surface texturing and modification. The laser interference nanolithography system comprises a high-power laser, a beam-splitting system, a wave plate and a polarizer. The laser interference nanolithography system is characterized in that two light beams are intervened, interference light beam parameters are controlled according to different implantation positions, a groove pattern produced through laser interference of the two light beams is utilized for directly processing the surface of a titanium alloy implant, a groove structure with the characteristic dimension adjustable from 100nm to 20 microns is formed, the geometrical morphology and the roughness of the surface of a material are changed, bio-mechanical bonding property of the titanium alloy implant with a bone is improved, osteoblast chemotaxis is guided, the biocompatibility of the implant is improved, and one-step titanium alloy implant surface texturing and modification is realized.

Description

technical field [0001] The present invention relates to a system for one-step texturing and modifying the surface of titanium alloy implants, which uses laser interference nanolithography technology to directly prepare micron to nanometer-scale surface structures on the surface of titanium alloy implants to change the geometry of the implant surface And roughness, improve the biocombination ability of implant-bone, and improve the biocompatibility of implant. Background technique [0002] At present, implant placement has achieved certain results in clinical practice, but there are still risks of failure and complications, such as implant loosening, peri-implant inflammation, peri-implant bone loss, and allergic reactions. The main cause of implant failure is that the metal implant cannot achieve good bone ingrowth with the bone tissue around the implant site. In the mid-1950s, it was found that titanium metal has excellent biocompatibility and is cheap, so titanium alloys ...

Claims

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Application Information

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IPC IPC(8): G03F7/20
CPCG03F7/2053
Inventor 李文君王作斌梁铂坚曹亮董莉彤宋正勋翁占坤许红梅
Owner CHANGCHUN UNIV OF SCI & TECH
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