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A method for functionalizing terahertz metamaterial chip hydrogel

A metamaterial and terahertz technology, applied in the field of terahertz biological detection, can solve problems such as scale mismatch, and achieve the effects of good versatility, strong non-specific adsorption ability, and high biocompatibility

Active Publication Date: 2019-12-24
THE FIRST AFFILIATED HOSPITAL OF ARMY MEDICAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the severe mismatch between the THz wavelength (1THz-300μm) and the scale of biomolecules (nm level), relevant research is still limited to the tablet detection of a large amount of biological substances and low-absorption media such as polyethylene in the THz band in a dry state.
Although the emerging THz metamaterial technology can increase the absorption cross-section of biological substances through the local resonance enhanced electric field generated by the periodic subwavelength metal structure to improve the detection sensitivity, and the coupling of the characteristic absorption peak of the substance and the resonant peak of the metamaterial has been used to improve detection. Specificity reports (Lee D K, Kang J H, Lee J S, et al. Highly sensitive and selective sugar detection by terahertz nano-antennas. [J]. Scientific Reports, 2015, 5:15459.), but the above detection is still in the target substance Measurements in the dry state

Method used

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  • A method for functionalizing terahertz metamaterial chip hydrogel
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  • A method for functionalizing terahertz metamaterial chip hydrogel

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Embodiment 1

[0048] In Embodiment 1 and Embodiment 2, a common THz metamaterial chip with a four-aperture single-resonant ring structure is used to illustrate the technical solution of the present invention. It should be noted that the present invention is not limited to the terahertz metamaterial chip with this specific structure, nor is it limited to the two specific target substances of glucose or alpha-fetoprotein.

[0049] The THz metamaterial chip is based on 2cm×2cm double-polished high-resistance silicon (500μm thick, resistivity greater than 10000Ω.cm), sputtering 20nm titanium and 180nm gold films on the silicon surface in sequence, and prepared by photolithography processing technology A metamaterial chip with a period of 70 μm, a metal wire frame width of 2 μm, and an opening gap of 4 μm, such as figure 1 shown. The low-frequency resonance sensing principle of the metamaterial chip is based on capacitive inductive coupling. For example, formula 1, the resonance frequency f is ...

Embodiment 2

[0061] Taking the modified aptamer hydrogel film on the surface of THz metamaterial for the label-free quantitative detection of human primary liver cancer tumor marker-alpha fetoprotein (AFP) as an example. Its detection principle is as Figure 6As shown, the aptamer molecule 7 that can specifically bind to AFP is modified on the polyacrylamide polymer chain 9, and the complementary chain 8 of the aptamer is modified. In the solution environment, the aptamer and the complementary chain specifically pair and combine to form the initial state. Aptamer gel10. In the presence of the target substance AFP 11, AFP can specifically bind to the aptamer molecule and promote its dissociation from the complementary chain, thereby changing the cross-linking density and charge density of the aptamer hydrogel network, making the aptamer The hydrogel undergoes a swelling change, and the swollen gel 12 is obtained, and the water content of the gel network increases. Therefore, the change of...

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Abstract

The invention relates to a terahertz metamaterial chip hydrogel functionalization method. The method comprises the steps that amino or other active functional groups are introduced to the surface of asubstrate of a terahertz metamaterial chip to achieve preprocessing, then, the surface of the preprocessed terahertz metamaterial chip is coated with a prepolymer monomer solution, a prepolymer filmis formed, and finally hydrogel functionalization of the terahertz metamaterial chip is achieved through a polymerization reaction. The intensive absorption characteristic of the THz waveband of waterand the water content changing characteristic in the response hydrogel and target molecule characteristic reaction process are ingeniously combined, and the target molecule special sensing problem inthe liquid phase environment is converted into high-sensitivity detection for the surface modified response hydrogel layer water content through the THz metamaterial technology. Meanwhile, the functionalization modification method is good in universality, simple, convenient to implement, rapid, high in nonspecific adsorption resistance and high in biocompatibility.

Description

technical field [0001] The invention belongs to the technical field of terahertz biological detection, and relates to a hydrogel functionalization method for a terahertz metamaterial chip. Background technique [0002] Terahertz (THz) waves refer to electromagnetic waves with a wavelength of 30μm-3mm and a frequency of 0.1THz-10THz, located between the microwave and infrared bands, in the transition zone from classical electromagnetics to quantum mechanics, and weak interactions between biological macromolecules The modes (hydrogen bond network, van der Waals forces, and collective vibration or rotation of the biomolecular backbone) lie in the THz band. Therefore, THz wave technology has broad prospects for application in biosensing. It can characterize the molecular structure and interaction of biological substances through different absorption peak positions and intensities in its wave band. However, limited by the serious mismatch between the THz wavelength (1 THz-300 μm...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F292/00C08F230/06C08F220/56C08F222/38G01N1/28
CPCC08F292/00G01N1/28C08F230/06C08F220/56
Inventor 赵祥府伟灵王云霞张立群王雪梅周杰熊瑜
Owner THE FIRST AFFILIATED HOSPITAL OF ARMY MEDICAL UNIV
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