Sol system used for preparing pH-sensitive double-network hydrogel, hydrogel and application

Abstract

The invention belongs to the field of environmental-stimulus-response-type medicines, and particularly relates to a sol system used for preparing pH-sensitive double-network hydrogel, the hydrogel andapplication. The sol system is prepared from gelatin methacryloyl, oxidized alginate, a photoinitiator, gentamicin and mesoporous silica nano particles loaded with phenamil medicinal molecules, the sol system is transformed from sol to gel fast under ultraviolet irradiation, thus the pH-sensitive double-network hydrogel can be obtained, and the hydrogel is excellent in physical and chemical property and good in biocompatibility, can effectively control release of an antibacterial medicine GS and an osteogenic differentiation promoting medicine phenamil, prevent early infection of a graft, induce C2C12 cell osteogenic differentiation, and promote endogenous bone generation. Based on the character that the sol system is transformed from the sol to the gel fast under ultraviolet irradiation,in practical application, in-situ gelation can be conducted by means of minimally-invasive injection, and the requirements of complex orbital bone defect repair can be met, so that the sol system used for preparing the pH-sensitive double-network hydrogel has important values in orbit repair and reconstruction.

Description

technical field [0001] The invention belongs to the field of environmental stimulus-responsive drugs, and in particular relates to a sol system for preparing pH-sensitive double-network hydrogels, hydrogels and applications thereof. Background technique [0002] Eyes are the most important organ of human senses, and about 80% of the knowledge in the brain is acquired through eyes. The orbital structure is complex. The bony orbital volume is about 30 mL, which accommodates tissues such as eyeballs, muscles, nerves, and blood vessels, and is adjacent to structures such as eyelids, nasal sinuses, brain, and deep facial tissues. As an important part of the orbit, the orbital bone not only has the physiological function of protecting the orbital contents from damage, but also plays an important role in maintaining the beauty of the face. Orbital bone defects can be caused by facial trauma, tumor invasion, congenital deformities or inflammatory diseases, often leading to serious ...

AI Technical Summary

Problems solved by technology

For example, clinically common bacterial infections on directly implanted or contacted medical devices such as catheters, contact lenses, and artificial joints adversely affect the quality of patient outcomes and lead to high medical costs

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