Fluorine-containing silicon-containing polyurethane material with high biological stability and preparation method thereof

A technology of biological stability and polyurethane materials, which is applied in the field of fluorine-containing silicon-containing polyurethane materials and its preparation, can solve the problems that the biological stability and mechanical properties cannot be improved simultaneously, the mechanical properties of polyurethane are reduced, and the biological stability and mechanical properties of polyurethane materials are difficult. At the same time, problems such as guarantee are obtained, and the effect of improving the body and surface properties and improving biological stability is achieved.

Active Publication Date: 2020-09-29
眉山尤博瑞特种新材料有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the introduction of fluorocarbons into the soft segment or hard segment of polyurethane will lead to a reduction in the mechanical properties of polyurethane, and the preparation of diols containing fluorocarbon side chains or fluorine-containing polyglycols is expensive
[0005] At present, the biological stability and mechanical properties of polyurethane materials are difficult to be guaranteed at the same time. How to develop new preparation methods to solve the problem that the biological stability and mechanical properties cannot be simultaneously improved during the preparation process has become an urgent technical problem to be solved.

Method used

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  • Fluorine-containing silicon-containing polyurethane material with high biological stability and preparation method thereof
  • Fluorine-containing silicon-containing polyurethane material with high biological stability and preparation method thereof
  • Fluorine-containing silicon-containing polyurethane material with high biological stability and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] The first step, the preparation of fluorosilicone polyether polyurethane prepolymer, add 90g of polytetrahydrofuran ether diol and 22g of hydroxyalkyl-terminated polydimethylsiloxane into a three-necked bottle with mechanical stirring at 100-105°C Vacuum dehydration for 2 hours until the water content in the raw material is less than 0.01%; then blow in N 2And cool down to 60-65°C, add 3.06g FDO (fluorine-containing dihydric alcohol), stir evenly and continue to cool down to 40-42°C, add 51g of molten completely transparent liquid MDI (methylene diphenyl diisocyanate) and 0.1% organic bismuth catalyst, stir rapidly until the temperature rises to 68-70°C, and maintain the temperature for 50 minutes until the NCO (isocyanate group) content reaches the designed theoretical value, that is, the fluorosilicon polyether polyurethane prepolymer is obtained.

[0037] The second step is the post-chain extension reaction. Cool the prepolymer prepared in the first step to 58-60°C, ...

Embodiment 2

[0040] The first step, the preparation of fluorosilicon polyether polyurethane prepolymer, add 0.095mol polyhexamethylene ether glycol and 0.005mol hydroxyethoxyl hydrocarbon group-terminated polydimethylsiloxane into three Vacuum dehydrate the bottle at 100-105°C for 2 hours until the water content in the raw material is less than 0.01%; then blow N 2 And lower the temperature to 60-65°C, add 0.01molHEPFOA (N-(1,1-Dihydroxymethylethyl) perfluorooctylamide, see patent: fluorine-containing diol CN1435410A), stir well and continue to cool down to 40- 42°C, add 0.25mol HDI (hexamethylene 1,6-diisocyanate) and 0.05% stannous octoate, stir rapidly until the temperature rises to 75-80°C, and maintain the reaction at this temperature for 50min until the NCO content reaches Design the theoretical value to obtain the fluorosilicone polyether polyurethane prepolymer.

[0041] The second step is the post-chain extension reaction. Cool the prepolymer prepared in the first step to 58-60 °...

Embodiment 3

[0044] The first step, the preparation of fluorosilicone polycarbonate polyurethane prepolymer, add 0.005mol poly 1,6-hexyl carbonate diol and 0.095mol hydroxyalkyl terminated polydimethylsiloxane into three Vacuum dehydrate the bottle at 100-105°C for 2 hours until the water content in the raw material is less than 0.01%; then blow N 2 And cool down to 60-65°C, add 0.001mol FDO, stir evenly and continue to cool down to 40-42°C, add 0.204mol molten and completely transparent liquid MDI and 0.1% organic bismuth, stir rapidly until the temperature rises to 50-55°C , and maintain the temperature at this temperature for 50 minutes until the NCO content reaches the design theoretical value, that is, the fluorosilicon polycarbonate polyurethane prepolymer is obtained.

[0045] The second step is the post-chain extension reaction. Add 0.099mol BDO to the prepolymer prepared in the first step, stir evenly at a high speed and raise the temperature to about 100°C. When the viscosity of ...

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Abstract

The invention provides a fluorosilicon polyurethane material with high biological stability, which belongs to the field of biomedical materials. The polyurethane of the invention uses polyether or polycarbonate diol as the first soft segment, polydimethylsiloxane diol as the second soft segment, and a rigid segment composed of diisocyanate and chain extender to copolymerize , wherein the chain extender is a small molecule diol or a diamine and a side chain fluorine-containing alkyl glycol blend. By taking advantage of the low surface energy characteristics of the two elements, fluorine and silicon, the two elements of the polyurethane can migrate to the surface to form a protective layer during melt processing or solution processing, which can prevent water and oxidizing media from penetrating into the material. Improve the hydrolysis resistance and anti-oxidation performance of the material, while improving the biological stability, endow the polyurethane material with excellent surface properties and bulk properties, which can be applied to the field of long-term implanted medical materials, such as artificial blood vessels, artificial heart valves, cardiac arresters, etc. pacemaker leads, various interventional catheters, etc.

Description

technical field [0001] The invention belongs to the technical field of polyurethane material preparation, and in particular relates to a fluorine-containing silicon-containing polyurethane material with high biological stability and a preparation method thereof. The material can be used as a medical material, especially a long-term implant material. Background technique [0002] Due to the excellent physical and mechanical properties and good biocompatibility of polyurethane, it has gained extensive attention in the field of biomedicine. However, the deficiencies in the stability of polyurethane limit its application as a long-term implant material to a certain extent, and it still faces great challenges in the application of cardiac pacemaker insulated wires and heart valves. In vivo biological stability is relatively poor. At present, polyether polyurethane (PEU) and polycarbonate polyurethane (PCU) are commonly used as long-term implant materials, but these two materials...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G18/66C08G18/61C08G18/48C08G18/38C08G18/32C08G18/44
CPCC08G18/3812C08G18/3825C08G18/44C08G18/4825C08G18/4854C08G18/61C08G18/664C08G18/6674
Inventor 谭鸿李震李洁华叶恒
Owner 眉山尤博瑞特种新材料有限公司
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