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Solution preparation for ginkgo leaf extract atomized inhalation and preparation method thereof

An atomization inhalation and ginkgo biloba technology, applied in the field of formulations, can solve the problems of no standardized use method, hidden safety hazards, no atomization inhalation solution dosage form, etc., so as to avoid first-pass effect, improve safety, and reduce tissue and organs. The effect of the distribution of

Pending Publication Date: 2019-07-05
BEIJING INCREASEPHARM SAFETY & EFFICACY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no special spray inhalation solution dosage form in all clinical applications at present, and there is no standardized method of use, and there are potential safety hazards in use.

Method used

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  • Solution preparation for ginkgo leaf extract atomized inhalation and preparation method thereof
  • Solution preparation for ginkgo leaf extract atomized inhalation and preparation method thereof
  • Solution preparation for ginkgo leaf extract atomized inhalation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] (1) Get 300g of fresh ginkgo leaves and carry out mechanical pulverization to obtain the ginkgo leaves pulverization;

[0043] (2) Add 8 times the volume of 60wt% ethanol aqueous solution to the crushed ginkgo leaves in step (1), reflux and extract for 2 hours, let it cool and filter, and collect the extract for the first time; then add 6 times the volume to the filter residue 60wt% ethanol aqueous solution, reflux extraction 2h, let cold filter, collect the second extract; Combine the first extract and the second extract, and distill under reduced pressure to obtain the concentrated ginkgo leaf paste;

[0044] (3) Add 1 times the volume of water to the Ginkgo Leaf Concentrated Paste of the step (2), stir and leave standstill for 24h, filter to obtain the column liquid on Ginkgo Leaf;

[0045] (4) adopt the macroporous resin column to purify the column solution on the ginkgo leaf of step (3), the eluent is 20wt%-40wt% ethanol aqueous solution, collect the eluent flowing...

Embodiment 2～8

[0049] Examples 2 to 8 except "on the basis of the prescription of Example 1, adding cosolvent in step (6)", other parameters and operations are the same as in Example 1, and the specific types and usage amounts of cosolvent are as shown in Table 1 Show:

[0050] The concrete kind and parameter of cosolvent of table 1 embodiment 2~8

[0051] serial number Co-solvent (g) Example 2 β-cyclodextrin (1.8g) Example 3 Poloxamer (1.8g) Example 4 Tween-80(1.8g) Example 5 Hydroxypropyl-β-cyclodextrin (0.9g), Tween-80 (0.9g) Example 6 Hydroxypropyl-β-cyclodextrin (0.9g), polyethylene glycol (0.9g) Example 7 β-cyclodextrin (12g) Example 8 Hydroxypropyl-β-cyclodextrin (3g), polyethylene glycol (9g)

Embodiment 9

[0053] (1) Get 150g of fresh ginkgo leaves and carry out mechanical pulverization to obtain the ginkgo leaves pulverization;

[0054] (2) Add 6 times the volume of 70wt% ethanol aqueous solution to the Ginkgo biloba pulverization in step (1), reflux for extraction for 2 hours, let it cool and filter, and collect the extract for the first time; then add 5 times the volume to the filter residue 60wt% ethanol aqueous solution, reflux extraction 2h, let cold filter, collect the second extract; Combine the first extract and the second extract, and distill under reduced pressure to obtain the concentrated ginkgo leaf paste;

[0055] (3) Add 1.2 times the volume of water to the Ginkgo Leaf Concentrated Paste of the step (2), stir and leave standstill for 24h, filter to obtain the column liquid on the Ginkgo Leaf;

[0056] (4) adopt the macroporous resin column to purify the column solution on the ginkgo leaf of step (3), the eluent is 20wt%-40wt% ethanol aqueous solution, collect the...

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Abstract

The present invention relates to a solution preparation for ginkgo leaf extract atomized inhalation and a preparation method thereof, and belongs to the field of pharmaceutics. The solution preparation for the ginkgo leaf extract atomized inhalation comprises an active ingredient, an isotonic agent and a solvent; wherein the active ingredient is an extract of ginkgo leaves of ginkgoaceae plants; and every liter of the solution for the atomized inhalation comprises the active ingredient prepared from more than or equal to 150 g of the ginkgo leaves. The provided solution for the ginkgo leaf extract atomized inhalation can rapidly form an aerosol through an atomizer, the formed aerosol can be directly and rapidly applied to affected parts, besides, the drug acting on the affected part can bequickly absorbed to take effect, and the solution preparation is less in use dose, also fast to take effects, good in efficacy and free of other toxic and side effects.

Description

technical field [0001] The invention relates to a ginkgo leaf extract solution preparation for atomized inhalation and a preparation method thereof, belonging to the field of pharmacy. Background technique [0002] Ginkgo biloba is the leaf of Ginkgo biloba plant. Ginkgo biloba leaves are sweet, bitter and astringent in nature, beneficial to the heart and lungs, reducing dampness and relieving diarrhea. "Chinese Medicine Chronicle" records that it can "contract lung qi, relieve asthma and cough, and stop turbidity". "Chinese Pharmacopoeia 2010 Edition" records that the functions and indications of Ginkgo biloba are: promoting blood circulation and removing blood stasis, dredging collaterals and relieving pain, astringing lungs and relieving asthma, reducing turbidity and lipids, used for blood stagnation, chest obstruction and heartache, stroke hemiplegia, lung deficiency cough and asthma, Hyperlipidemia. According to modern pharmacological research, ginkgo biloba has a w...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/16A61K9/72A61P11/00A61K127/00
CPCA61K9/0078A61K36/16A61K2236/331A61K2236/39A61K2236/51A61K2236/53
Inventor 张保献胡杰
Owner BEIJING INCREASEPHARM SAFETY & EFFICACY CO LTD
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