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Mesoporous silica nanosphere, preparation method thereof, and application of nanosphere in drug load

A technology of mesoporous silica and nanospheres, applied in silica, silica, nanotechnology and other directions, can solve the problems of low drug dissolution rate and unsatisfactory bioavailability, and achieve theoretical and practical significance. Good application prospect, green and environmental protection effect in the preparation process

Active Publication Date: 2019-06-18
HUAZHONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] However, in the relevant research reports on the currently used silica as a carrier for loading insoluble drugs, the dissolution rate of the drug is not high, and the bioavailability is not ideal.

Method used

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  • Mesoporous silica nanosphere, preparation method thereof, and application of nanosphere in drug load
  • Mesoporous silica nanosphere, preparation method thereof, and application of nanosphere in drug load
  • Mesoporous silica nanosphere, preparation method thereof, and application of nanosphere in drug load

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Embodiment 1

[0056] Embodiment 1 of the present invention provides a method for preparing mesoporous silica nanospheres, the specific steps are as follows:

[0057] Measure 78mL of deionized water, 27mL of absolute ethanol, and 0.75mL of ammonia water. After mixing, add 0.3g of CTAB (cetyltrimethylammonium bromide) and ultrasonically mix to obtain solution A; measure 1.65mL of TEOS , and fully mixed with 2.175mL of absolute ethanol, wherein the volume ratio of TEOS (tetraethyl orthosilicate) to absolute ethanol is 0.758, to obtain solution B; quickly add solution B to solution A, seal, and magnetically stir React for 24 hours; then filter the obtained product with suction, wash with deionized water and absolute ethanol three times each, until neutral.

[0058] The suction-filtered product was dried at 50° C. for 12 hours, and then calcined in a muffle furnace at 550° C. for 5 hours to obtain mesoporous silica nanospheres with a diameter of 50 nm.

[0059] figure 1 and figure 2 These ar...

Embodiment 2

[0062] Embodiment 2 of the present invention provides a method for preparing mesoporous silica nanospheres, the specific steps are as follows:

[0063] Measure 78mL of deionized water, 27mL of absolute ethanol, and 0.75mL of ammonia water, mix well, add 0.3g of CTAB, and ultrasonically mix to obtain solution A. Measure 1.65mL of TEOS and fully mix with 1.25mL of absolute ethanol, wherein the volume ratio of TEOS to absolute ethanol is 1.32 to obtain solution B. Solution B was quickly added to solution A, sealed, and magnetically stirred for 24 hours. Then the obtained product was subjected to suction filtration, washed with deionized water and absolute ethanol three times, until neutral.

[0064] The suction-filtered product was dried at 50° C. for 12 hours, and then calcined in a muffle furnace at 550° C. for 5 hours to obtain mesoporous silica nanospheres with a diameter of 150 nm.

[0065] Figure 5 and Figure 6 These are the scanning electron micrographs of the mesopo...

Embodiment 3

[0067] Embodiment 3 of the present invention provides a method for preparing mesoporous silica nanospheres, the specific steps are as follows:

[0068] Measure 27mL of deionized water, 78mL of absolute ethanol, and 0.75mL of ammonia water, mix well, add 0.3g of CTAB, and ultrasonically mix to obtain solution A. Measure 1.65mL of TEOS and fully mix with 1.25mL of absolute ethanol, wherein the volume ratio of TEOS to absolute ethanol is 1.32 to obtain solution B. Solution B was quickly added to solution A, sealed, and magnetically stirred for 24 hours. Then the obtained product was subjected to suction filtration, washed with deionized water and absolute ethanol three times, until neutral.

[0069] The suction-filtered product was dried at 50° C. for 12 hours, and then calcined in a muffle furnace at 550° C. for 5 hours to obtain mesoporous silica nanospheres with a diameter of 1 μm.

[0070] Figure 7 and Figure 8 These are the scanning electron micrographs of the mesoporo...

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Abstract

The invention discloses a mesoporous silica nanosphere, a preparation method thereof, and an application of the nanosphere in drug load. The preparation method comprises the following steps: adding asilicon source solution composed of a silicone source and a diluent to a mixed aqueous solution containing a surfactant, a catalyst and a diluent, stirring and reacting the obtained solution, filtering the obtained solution, washing the obtained reaction product, and calcining the washed reaction product. The prepared sample has a particle size of 40-200 nm, a specific surface area of 1050-1350m<2> / g and a pore size of 1.8-2.4 nm; and the product is applied to the loading of hydrophobic drugs to achieve nanocrystallization of the drugs and enhance the water solubility and the dissolution rate. The method provided by the invention has the advantages of avoiding of the use of an organic template for traditional mesoporous silica nanospheres, easily available raw materials, simple device and high efficiency; and introduction of pore wall particles to the mesoporous structure facilitates diffusion and load of drugs, reduces rerystallization, and makes the in vitro dissolution rate be almost 100%, so the drugs have significantly higher bioavailability than commercial drugs, and have great actual significance.

Description

technical field [0001] The invention relates to the field of nanomaterials for hydrophobic drug loading, in particular to a mesoporous silica nanosphere, a preparation method thereof, and an application in drug loading. Background technique [0002] Oral drug delivery system is the most convenient and widely used method of drug delivery clinically. After oral administration, the drug is absorbed by the mucous membrane in the oral cavity or gastrointestinal tract, and then enters the blood circulation to reach the tissues in the body to play a therapeutic role. In the case of oral administration, the absorption process of drugs through organs such as the gastrointestinal tract is a very complex physiological process. The speed and degree of drug absorption are affected by many aspects, including the physical and chemical properties of the drug itself, the dosage form of the drug, the absorption site, and the physiological environment of the digestive tract. The main barrier...

Claims

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Application Information

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IPC IPC(8): C01B33/18A61K47/04A61K31/496B82Y40/00
Inventor 罗志强万影任小宁程思余晓凤万江陵
Owner HUAZHONG UNIV OF SCI & TECH
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