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Method for preparing biological active coating layer on surface of zirconia convenient for synostosis

A bioactive, zirconia technology, used in coatings, drug delivery, pharmaceutical formulations, etc., can solve the problems of precipitation, causing allergic reactions, and less surface organic functional groups, achieving simple and effective preparation process, good surface wettability, The effect of promoting tissue mineralization

Inactive Publication Date: 2019-04-26
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Among them, pure titanium and titanium alloy implants are widely used in the field of oral implants because of their good biocompatibility, corrosion resistance, mechanical properties, and osseointegration capabilities, and have achieved good restoration results. A large number of studies have pointed out the shortcomings of titanium and titanium alloy implants, such as: the application of titanium in the human body may cause allergic reactions, titanium has a current effect after contact with saliva, and titanium hexaluminum tetravanadium is the most widely used titanium alloy Implant materials have the problem of precipitation of aluminum ions and vanadium ions, which affects human health
In addition, esthetic problems in the anterior region due to gingival recession, abutment exposure, and gingival staining have been difficult to resolve
[0004] Scholars at home and abroad have done a lot of in vivo and in vitro experiments to evaluate the feasibility of zirconia as an implant material, but the results show that the osteogenic properties of zirconia materials are not satisfactory.
Because zirconia is a biologically inert material with stable chemical properties and less organic functional groups on the surface, it is not conducive to the adsorption of proteins and osteoblasts. Compared with pure titanium implants, the osteogenic induction is not good, which greatly limits Application of zirconia materials in the field of planting

Method used

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  • Method for preparing biological active coating layer on surface of zirconia convenient for synostosis
  • Method for preparing biological active coating layer on surface of zirconia convenient for synostosis
  • Method for preparing biological active coating layer on surface of zirconia convenient for synostosis

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Embodiment 1

[0037] A method for preparing a bioactive coating on the surface of zirconia that is convenient for osseointegration, comprising the following steps:

[0038] (1) Rinse the flaky zirconia specimen with distilled water for 10 minutes, ultrasonically rinse it in acetone for 15 minutes, then ultrasonically rinse it in acetone for 15 minutes, and finally rinse it twice with deionized water, each time for 15 minutes; Dry in an oven at 37°C. Carry out magnesium ion implantation after cleaning, parameter: implantation voltage is 15keV, and magnesium ion concentration is 2.3×10 15 ion / cm 2 ;

[0039] (2) Put the ion-implanted zirconia specimen into a 5mol / L sodium hydroxide solution, put it in a water bath at 60°C overnight, carry out surface hydroxylation on the zirconia specimen, and place the hydroxylated specimen in a nitrogen atmosphere After drying, put it into a container sterilized by high temperature and high pressure, then add 7mL pentane, 1.2mL CPTES and 0.6mL DIEA into ...

Embodiment 2

[0042] A method for preparing a bioactive coating on the surface of zirconia that is convenient for osseointegration, comprising the following steps:

[0043] (1) Rinse the flaky zirconia specimen with distilled water for 10 minutes, ultrasonically rinse it in acetone for 15 minutes, then ultrasonically rinse it in acetone for 15 minutes, and finally rinse it twice with deionized water, each time for 15 minutes; Dry in an oven at 37°C. Carry out magnesium ion implantation after cleaning, parameter: implantation voltage is 17keV, and magnesium ion concentration is 2.5×10 15 ion / cm 2 ;

[0044](2) Put the ion-implanted zirconia specimen into a 5mol / L sodium hydroxide solution, put it in a water bath at 60°C overnight, carry out surface hydroxylation on the zirconia specimen, and place the hydroxylated specimen in a nitrogen atmosphere After drying, put it into a container sterilized by high temperature and high pressure, then add 7mL pentane, 1.2mL CPTES and 0.6mL DIEA into t...

Embodiment 3

[0046] A method for preparing a bioactive coating on the surface of zirconia that is convenient for osseointegration, comprising the following steps:

[0047] (1) Rinse the flaky zirconia specimen with distilled water for 10 minutes, ultrasonically rinse it in acetone for 15 minutes, then ultrasonically rinse it in acetone for 15 minutes, and finally rinse it twice with deionized water, each time for 15 minutes; Dry in an oven at 37°C. Carry out magnesium ion implantation after cleaning, parameter: implantation voltage is 20keV, and magnesium ion concentration is 3.0×10 15 ion / cm 2 ;

[0048] (2) Put the ion-implanted zirconia specimen into a 5mol / L sodium hydroxide solution, put it in a water bath at 60°C overnight, carry out surface hydroxylation on the zirconia specimen, and place the hydroxylated specimen in a nitrogen atmosphere After drying, put it into a container sterilized by high temperature and high pressure, then add 7mL pentane, 1.2mL CPTES and 0.6mL DIEA into ...

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Abstract

The invention relates to a method for preparing a biological active coating layer on the surface of zirconia convenient for synostosis. The method comprises the following steps: (1) carrying out magnesium ion implantation after sequentially putting and washing zirconia test pieces, wherein the implantation voltage is 10 to 20 keV, and the magnesium ion concentration is 2 to 3*10<15> ion / cm<2>; (2)carrying out arginine-glycine-aspartic acid tripeptide complex connection on the surface of the zirconia test pieces after the magnesium ion implantation. The test pieces prepared through zirconia for preparing the biological active coating layer are beneficial for adhesion, extension and proliferation of osteoblast, and meanwhile, tissue mineralization can be promoted.

Description

technical field [0001] The invention relates to a method for preparing a bioactive coating on the surface of zirconia which is convenient for osseointegration, and belongs to the technical field of dental implants. Background technique [0002] In modern stomatology, implant-supported crown restoration and complete denture restoration are important methods for treating dentition defects and missing teeth. Among them, pure titanium and titanium alloy implants are widely used in the field of oral implants because of their good biocompatibility, corrosion resistance, mechanical properties, and osseointegration capabilities, and have achieved good restoration results. A large number of studies have pointed out the shortcomings of titanium and titanium alloy implants, such as: the application of titanium in the human body may cause allergic reactions, titanium has a current effect after contact with saliva, and titanium hexaluminum tetravanadium is the most widely used titanium a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/10A61L27/28A61L27/02
CPCA61L27/025A61L27/10A61L27/28A61L2300/102A61L2300/252A61L2300/412A61L2300/45A61L2300/606A61L2400/18A61L2420/02
Inventor 蓝菁王志峰黄正非刘奇博李传花王飞龙
Owner SHANDONG UNIV
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