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Preparation method of near-infrared light-enriched cysteine-modified bismuth sulfide hollow spheres and its application in photothermal therapy and drug controlled release

A technology of cysteine ​​and near-infrared light, which is applied in the fields of biomedical technology and nanomaterial science, can solve the problems of poor biocompatibility of materials, low photothermal conversion efficiency, and small drug loading, and achieve the purpose of increasing adsorption sites , improve the light-to-heat conversion efficiency, and the effect of less equipment

Active Publication Date: 2021-03-05
XINXIANG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the bottleneck problems faced by photothermal therapy of tumors are poor biocompatibility of materials, low photothermal conversion efficiency, small drug loading and difficulty in precise release.

Method used

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  • Preparation method of near-infrared light-enriched cysteine-modified bismuth sulfide hollow spheres and its application in photothermal therapy and drug controlled release
  • Preparation method of near-infrared light-enriched cysteine-modified bismuth sulfide hollow spheres and its application in photothermal therapy and drug controlled release
  • Preparation method of near-infrared light-enriched cysteine-modified bismuth sulfide hollow spheres and its application in photothermal therapy and drug controlled release

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] (1) Preparation of bismuth composite microspheres: 60 mL ethanol-glycerol mixed solution (V 乙醇 :V 甘油 =1:1) as a solvent, after magnetic stirring at room temperature for 0.5 hours, 1.4550 g Bi(NO 3 ) 3 • 5H 2 O, stir to completely dissolve the bismuth nitrate to form a clear solution. Then 0.5 g of polyvinylpyrrolidone (PVP) was added, and magnetic stirring was continued for 1 hour to obtain a mixed solution. The mixed solution was transferred to a 100 mL polytetrafluoroethylene-lined autoclave, sealed, and placed in an oven at a constant temperature of 160°C for 3 hours. Finally, the reactor was naturally cooled to room temperature, and the precipitate was collected by centrifugation, washed and dried to obtain bismuth complex microspheres (Gly-Bi-PVP).

[0036] (2) L-Cys / Bi 2 S 3 Synthesis of hollow spheres: Weigh 0.1 g of bismuth composite microspheres obtained in step (1) and disperse them in 10 mL of distilled water, then add 0.242 g of L-cysteine ​​(L-Cys) a...

Embodiment 2

[0040] Embodiment 2 (comparative example)

[0041] L-Cys / Bi 2 S 3 Preparation of solid spheres: with 30 mL ethanol-glycerol mixed solution (V 乙醇 :V 甘油 =1:1) as a solvent, after magnetic stirring at room temperature for 0.5 hours, 1.4550 g Bi(NO 3 ) 3 • 5H 2 O, stir to completely dissolve the bismuth nitrate to form a clear solution A. Dissolve 0.5 g of L-cysteine ​​in 30 mL of distilled water to form solution B. Slowly add B dropwise into solution A under magnetic stirring, and continue magnetic stirring for 1 hour. Transfer it to a 100 mL polytetrafluoroethylene-lined autoclave, seal it, and place it in an oven at a constant temperature of 160°C for 6 hours. Finally, the reactor was naturally cooled to room temperature, and the precipitate was collected by centrifugation, washed and dried to obtain L-Cys / Bi 2 S 3 Solid ball.

[0042] Figure 5 for L-Cys / Bi 2 S 3 UV-Vis-NIR diffuse reflectance spectra of hollow and solid sphere samples. As shown, in the visible ...

Embodiment 3

[0044] Example 3 (photothermal performance test)

[0045] L-Cys / Bi 2 S 3 Hollow sphere and solid sphere samples were prepared into 500 µg / mL aqueous solution, and 2 mL each was placed in a cuvette. Put it at an optical power density of 1 W / cm 2 The 808 nm near-infrared light was irradiated, and the temperature change of the solution was monitored with an electronic sensing thermocouple thermometer. The result is as Figure 7 As shown, L-Cys / Bi 2 S 3 The hollow sphere can heat up rapidly under the irradiation of the laser, compared to the L-Cys / Bi 2 S 3 For solid spheres, L-Cys / Bi 2 S 3 Hollow spheres have high light-to-heat conversion capabilities.

[0046] Mix 2 mL of distilled water and 500 µg / mL of L-Cys / Bi 2 S 3 The hollow sphere aqueous solution was irradiated with laser light for 10 min, and then the laser was turned off to cool down to room temperature naturally. The temperature change during the recording period was recorded by a thermocouple, and the tempe...

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Abstract

The invention discloses a preparation method of bismuth sulfide hollow spheres modified by near-infrared light-enriched cysteine ​​and its application in photothermal therapy and drug controlled release, which solves the problem of relatively low photothermal conversion efficiency of materials in the prior art. Low and difficult to achieve synergistic treatment of photothermal and drugs. The present invention first utilizes polyvinylpyrrolidone as a complexing agent to prepare bismuth complex precursor microspheres in a glycerol / ethanol mixed solvent; then uses bismuth complex microspheres as a template, and selects L-cysteine ​​as a sulfur source and Surface modifier, hydrothermally synthesized to obtain L‑Cys / Bi 2 S 3 Hollow spheres, the hollow spheres are composed of nanorods with an average particle size of 250-300 nm. The obtained bismuth sulfide hollow spheres have significantly enhanced near-infrared light capture ability and photothermal conversion effect, and have strong drug loading and controlled release performance, and can be used for combined treatment of tumor photothermal ablation and drug chemotherapy.

Description

technical field [0001] The invention belongs to the field of biomedical technology and nanomaterial science, relates to the technical field of tumor photothermal imaging and photothermal therapy, and in particular to a preparation method of near-infrared light-enriched cysteine-modified bismuth sulfide hollow spheres and its application in light Applications in heat therapy and controlled drug release. Background technique [0002] Bismuth (Bi) is the only metal element that is relatively cheap, low-toxic and low-radioactive. Due to its unique "green" properties, bismuth compounds have been widely used in the fields of medicine, health and environmental energy. Bi 2 S 3 It is a narrow bandgap semiconductor material (Eg≈1.3eV) with a layered structure. Its narrow energy gap and large absorbance make it an ideal near-infrared light absorbing material. Its absorbing performance depends on bandwidth, nanostructure, and morphology. with dimensions. [0003] Photothermal ther...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K41/00A61K31/704A61K47/02A61K47/69A61K49/04A61P35/00
CPCA61K31/704A61K41/0052A61K47/02A61K49/04A61K49/049A61K47/6929A61K47/6949A61P35/00A61K2300/00
Inventor 闫云辉刘林霞王佳郭琪莹
Owner XINXIANG MEDICAL UNIV
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