Photosensitizer and preparation method thereof
A photosensitizer and carrier technology, applied in the field of photosensitizers, can solve the problems of low luminous efficiency, shallow tissue penetration depth, etc., and achieve the effects of simple preparation process, strong absorption efficiency, and high-efficiency photodynamic therapy
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[0042] The invention provides a method for preparing a photosensitizer, which is characterized in that it comprises the following steps:
[0043] S01: Heat 1 equivalent of gadolinium chloride, 15-50 equivalents of oleic acid, and 35-70 equivalents of octadecene in an inert gas environment; add 5-10 equivalents of NH after cooling 4 F and 1-2 times the equivalent of NaOH were reacted at 300°C for 1 hour, and NaGdF was obtained after precipitation treatment 4 Nanoparticles;
[0044] S02: 3 equivalents of yttrium trifluoroacetate, 1 equivalent of ytterbium trifluoroacetate, 0.1 equivalent of erbium trifluoroacetate, 50-100 equivalents of oleic acid, 30-60 equivalents of octadecene, and NaGdF4 in step S01 For nanoparticles, react in an inert gas environment at 280-320°C for 20-40min, and precipitate;
[0045] S03: 5 equivalents of yttrium trifluoroacetate, 1 equivalent of neodymium trifluoroacetate, 50-100 equivalents of oleic acid, 30-60 equivalents of octadecene, and NaGdF in ...
Embodiment 1
[0055] Upconversion Gd@Er@Nd@Lu(UP) multi-shell nanoparticles were prepared by thermal-co-precipitation method. ① First, prepare NaGdF 4 Nanoparticles, weighed gadolinium chloride GdCl 3 ·6H 2 O 0.3717g was added in the three-necked bottle, and 6ml oleic acid and 15ml octadecene were measured simultaneously in the three-necked bottle. Then, pass argon gas for 40 minutes to remove water vapor and oxygen in the reaction flask. Then heat up to 160°C, react for 30 minutes, cool down to room temperature, add NH 4 F (0.1480g) and NaOH (0.1000g), then heated to 100°C, after methanol was removed, the temperature was rapidly raised to 300°C, reacted for 1 hour, and finally lowered to room temperature, centrifuged with ethanol, and dispersed into n-hexane solution. ②Preparation of Gd@Er nanoparticles, first, weigh the corresponding amount of yttrium trifluoroacetate Y(CF 3 COO) 3 0.3336g, ytterbium trifluoroacetate Yb (CF 3 COO) 3 0.1024g, erbium trifluoroacetate Er (CF 3 COO...
Embodiment 2
[0057] Preparation of upconverting nanoparticles co-loaded with photosensitizers. First, the upconverting nanoparticles are phase-transferred. We used the amphiphilic polymer TWEEN20 to transfer the oily upconverting nanoparticles into the aqueous phase, then loaded the photosensitizer merocyanine (MC540) and chlorin (Ce6) molecules, stirred overnight, and then centrifuged to obtain the product UPMC and dispersed in PBS. Finally, polyethylene glycol-folate (DEPE-mPEG) was used to increase the biocompatibility of the nano-photosensitizer. Such as Figure 4 Shown, in the case of 50μg / mL cell viability was significantly reduced.
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