Double-modified collagen scaffold and application of double-modified collagen scaffold in product for repairing of spinal cord injury

Abstract

The invention discloses a double-modified collagen scaffold and an application of the double-modified collagen scaffold in a product for repairing of spinal cord injury. The double-modified collagen scaffold comprises a collagen scaffold material, and an EGFR antibody and microtubule stabilizing molecules modified on the collagen scaffold material. The EGFR antibody cetuximab and the microtubule stabilizing molecule paclitaxel are combined to modify the linear ordered collagen scaffold material, which can effectively antagonize the inhibitory effect of myelin-related inhibitory molecules on nerve regeneration by blocking the activation of an EGFR signaling pathway, the collagen scaffold promotes the generation of more neurons in the spinal cord injury position, is beneficial to the myelination of nerve fibers, and can also promote the regeneration of axons by stabilizing the structure of microtubules, reduces the deposition of inhibitory scar components in a injured area, blocks the formation of inhibitory scars, and reconstructs the spinal cord neural circuit, and ultimately achieves better behavioral recovery after spinal cord injury.

Description

technical field [0001] The invention relates to a double-modified collagen scaffold, in particular to a linear ordered collagen scaffold for repairing spinal cord injuries and a preparation method thereof, as well as its application in preparing products for repairing spinal cord injuries, belonging to the technical field of biomedical materials . Background technique [0002] Spinal cord injury is a common severe central nervous system injury clinically, often causing permanent sensory and motor dysfunction below the level of injury, which brings great pain to patients and their families. Moreover, the current treatment of spinal cord injury still faces major challenges. [0003] Collagen is the main component of the extracellular matrix, which has the characteristics of good biocompatibility and low immunogenicity. Collagen materials can be used as biomaterials for guiding nerve regeneration. Previously, the inventor of this case developed a linear and ordered collagen ...

AI Technical Summary

Problems solved by technology

[0004] At present, there are more and more repair strategies to guide nerve regeneration after spinal cord injury, but research on spinal cord injury repair targeting a single factor can only promote nerve regeneration after injury to a certain extent

The neuron regeneration and functional recovery that can be observed in the repair method only targeting a specific factor are not optimistic

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