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Novel application of herba cistanche phenylethanoid glycoside in improving sleep and application thereof

A phenethyloside and a technology for improving sleep are applied to the new use of Cistanche deserticola phenethyloside for improving sleep and its application field, which can solve the problems of no reports on improving sleep function, and achieve the effect of high yield and sleep improvement.

Active Publication Date: 2019-01-01
大连五舟神草健康科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Through the search of literature and books, no report on Cistanche deserticola and its active ingredients for improving sleep function was found.

Method used

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  • Novel application of herba cistanche phenylethanoid glycoside in improving sleep and application thereof
  • Novel application of herba cistanche phenylethanoid glycoside in improving sleep and application thereof
  • Novel application of herba cistanche phenylethanoid glycoside in improving sleep and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1 Preparation and content determination of phenylethanol glycosides in Cistanche deserticola.

[0025] 1. Extraction process: desert cistanche decoction pieces (batch number: C170160, Dalian Quanjian Chinese Medicine Decoction Pieces Co., Ltd.), crushed into 20-40 mesh coarse powder, weighed 1 kg, refluxed with 12 L 70% ethanol (volume ratio), 80 °C Extract 2 times, 2 hours each time; combine the extracts, concentrate under reduced pressure at 50°C to a paste, add a small amount of water to make a suspension of 1 L, and obtain the Cistanche deserticola extract solution.

[0026] 2. Purification process: Take the extract of Cistanche deserticola and put it on a D101 macroporous adsorption resin column. The volume ratio of resin to crude drug is 1:1, and the diameter-to-height ratio of the macroporous adsorption resin column is 1:9. Impurities were then eluted with 4 BV of 60% ethanol, the eluate was concentrated under reduced pressure at 50°C, and vacuum-dried at...

Embodiment 2

[0034] Example 2 Study on improvement of sleep function of asthenic insomnia model mice by phenylethanol glycoside of Cistanche deserticola.

[0035] 1. Experimental materials.

[0036] 1.1 Animals.

[0037] 60 ICR mice, male, weighing 20-22 g, 6-8 weeks old, provided by Liaoning Changsheng Biotechnology Co., Ltd. ) ℃, relative humidity 65%, and normal circadian rhythm to adjust the light time environment, eat standard feed and drink water freely.

[0038] 1.2 Main reagents and equipment.

[0039] Normal saline (batch number: 1607211208, Jilin Dubang Pharmaceutical Co., Ltd.); p-chlorophenylalanine (Sigma, USA); 5-HT, DA, ACTH kit (batch number: 201807, Shanghai Youyou Biotechnology Co., Ltd. ); diazepam tablets (batch number: 20171005, Jining Ankang Pharmaceutical Co., Ltd.); Cistanche cistanche phenylethanol glycoside extract (prepared by Example 1); TDZ4-WS low-speed desktop centrifuge (Changsha Xiangyi Centrifuge Instrument Co., Ltd. ); HH-S type electric heating const...

Embodiment 3

[0055] Example 3 Using the test method for improving sleep function to evaluate the research on improving sleep function of phenylethanol glycosides from Cistanche deserticola.

[0056] 1. Experimental materials.

[0057] 1.1 Animals.

[0058] 120 ICR mice, male, weighing 20-22 g, 6-8 weeks old, provided by Liaoning Changsheng Biotechnology Co., Ltd. ) ℃, relative humidity 65%, and normal circadian rhythm to adjust the light time environment, eat standard feed and drink water freely.

[0059] 1.2 Main reagents.

[0060] Cistanche cistanche phenylethanol glycoside extract (prepared in Example 1), pentobarbital sodium (US Sigma Company), barbital sodium (US Sigma Company).

[0061] 1.3 Grouping and dose selection.

[0062] 120 mice were divided into 3 batches for the experiment. The first batch of animals was used for direct sleep experiment and prolonged pentobarbital sodium sleep time experiment, and the second batch of animals was used for pentobarbital sodium subthreshol...

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Abstract

The invention relates to the pharmacological effect of phenylethanoid glycoside as an active ingredient in herba cistanche as a traditional Chinese medicine for anti-insomnia and application thereof,and in particular to the preparation of phenylethanoid glycoside and application thereof in drugs for treating insomnia and health-care food. A pharmacological experiment indicates that phenylethanoidglycoside has a strong effect in improving the sleep function. Phenylethanoid glycoside in the herba cistanche has good activity in improving the sleep function, side effects are small, the price islow, the druggability is good, and phenylethanoid glycoside can be used alone or in combination with other drugs for preparing drugs for improving the sleep function. Phenylethanoid glycoside and pharmaceutically acceptable or food-acceptable carriers or excipients can be prepared into dosage forms of granules, capsules, tablets and the like.

Description

technical field [0001] The invention relates to the pharmacological action and application of the active ingredient phenylethanol glycoside in the traditional Chinese medicine Cistanche deserticola, in particular to the preparation of the cistanche deserticola phenylethanol glycoside and the use of the cistanche deserticola phenylethanol glycoside as an active ingredient in sleep-improving medicine and health food. Background technique [0002] Insomnia is the most common type of clinical sleep disorder, usually refers to a subjective experience of patients who are not satisfied with sleep time and (or) quality and affects daytime social function (Chinese Guidelines for the diagnosis and treatment of adult insomnia[J].Chinese Journal of Neurology , 2012, 45(5): 534-540.). Due to the acceleration of the pace of social life and the continuous increase of work pressure, insomnia has become one of the most common diseases that plague people's lives. Modern medicine often treats...

Claims

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Application Information

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IPC IPC(8): A61K36/64A61P25/20A23L33/105A61K31/7032
CPCA23V2002/00A61K31/7032A61K36/64A61K2236/333A61K2236/39A61K2236/55A23L33/105A61P25/20A23V2200/30A23V2250/21
Inventor 窦德强朱连连
Owner 大连五舟神草健康科技有限公司
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