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A traditional Chinese medicine silver titanate composite porous material for burn wound healing and its preparation method and application

A wound healing, porous material technology, applied in the field of medical materials, can solve the problems of no antibacterial activity and anti-infection effect, unable to deal with the easy infection of burn wounds, etc., to avoid toxicity and irritation, soft texture, good antibacterial properties. Effect

Active Publication Date: 2021-04-06
SHANGHAI CHANGHAI HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it has no antibacterial activity and anti-infection effect, and cannot cope with the characteristics of burn wounds that are susceptible to infection
[0009] Combining traditional Chinese medicine with modern medical dressing technology, using Baijijiao and carboxymethyl chitosan as polymer film-forming materials to prepare traditional Chinese medicine-silver titanate composite porous materials for burn wound healing has not been reported

Method used

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  • A traditional Chinese medicine silver titanate composite porous material for burn wound healing and its preparation method and application
  • A traditional Chinese medicine silver titanate composite porous material for burn wound healing and its preparation method and application
  • A traditional Chinese medicine silver titanate composite porous material for burn wound healing and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Screening of the ratio of Baijijiao and carboxymethyl chitosan in traditional Chinese medicine silver titanate composite porous material for burn wound healing

[0043] Crush the Baiji decoction pieces, add 7 times the amount of distilled water to soak for 12 hours, stir, filter, and the filtrate is set aside. The dregs are then soaked in 4 times the amount of water for 3 times, each time for 6 hours, and then filtered. The 4 filtrates were combined and concentrated, and the relative density was 1.10 (65°C). After cooling, add 95% ethanol to make the alcohol content reach 70%. Stir to precipitate a large amount of floc, leave it to stand, vacuum filter to dryness, add ethanol to the precipitate and stir, let stand, make it fully dehydrated (dehydration 3 times), suction filtration to dryness, so that the ethanol is volatilized, dried in an oven at low temperature, and grinded a little, to obtain yellow-brown dry powdered white and polysaccharide, that is, white and glu...

Embodiment 2

[0060] A method for preparing a traditional Chinese medicine silver titanate composite porous material for burn wound healing, comprising the following steps:

[0061] Adopt hydrothermal method and ultraviolet light photodeposition method to prepare silver titanate material: in 5ml tetrabutyl titanate (Sinopharm Group Chemical Reagent Co., Ltd.), drop 0.6ml concentration and be 40% hydrofluoric acid (Sinopharm Group Chemical Reagent Co., Ltd.) company), treated in a hydrothermal reaction kettle at 180°C for 36 hours, added silver nitrate with an intermediate mass of 1.0% to the intermediate, and deposited it with ultraviolet light for 30 minutes, and then put the final product at -20°C and a pressure of 1.0mBar. Freeze-dry for 12 hours to obtain the silver titanate.

[0062] Take 10mL of 100mg / mL baicalin solution, 10mL of Baijijiao glue with a concentration of 5%, and 30mL of carboxymethyl chitosan glue with a concentration of 4%. After mixing, place them in a water bath at 5...

Embodiment 3

[0065] Morphological observation of traditional Chinese medicine silver titanate composite porous material for burn wound healing

[0066] Take the traditional Chinese medicine silver titanate composite porous material used for burn wound healing prepared in Example 2, place it on a sample plate with double-sided adhesive tape, observe it under a scanning electron microscope after gold plating, and obtain the traditional Chinese medicine for burn wound healing Morphology of silver titanate composite porous material. like figure 2 , image 3 , Figure 4 as shown, figure 2 It is the scanning electron microscope figure (SEM 200X) of the traditional Chinese medicine silver titanate composite porous material that is used for burn wound healing that embodiment 2 prepares, image 3 It is the scanning electron micrograph (SEM 1000X) of the traditional Chinese medicine silver titanate composite porous material that is used for burn wound healing that embodiment 2 prepares, Figu...

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Abstract

The invention discloses a traditional Chinese medicine silver titanate composite porous material used for burn wound healing, which is composed of baicalin solution, baijijiao glue and carboxymethyl chitosan with a volume ratio of 1:1:(1-5). Sugar glue solution is made, wherein: the concentration of baicalin solution is 100mg / mL, the concentration of white gelatin glue solution is 5%, the concentration of carboxymethyl chitosan glue solution is 4%; The loading capacity of silver titanate is 0.1~5wt%. The invention also discloses an application of the traditional Chinese medicine silver titanate composite porous material used for burn wound healing in preparation of burn wound healing medicine. The traditional Chinese medicine silver titanate composite porous material for burn wound healing prepared by the invention has no skin irritation, has good antibacterial properties, water absorption and air permeability, and has obvious healing promotion effect on burn wounds.

Description

technical field [0001] The invention belongs to the technical field of medical materials, and in particular relates to a traditional Chinese medicine silver titanate composite porous material used for burn wound healing, a preparation method and application. Background technique [0002] Burns are common injuries in daily life, and the incidence of burns in wartime is also increasing. Therefore, research on burn treatment has important social and military significance. The key to the treatment of burn wounds is anti-infection and promotion of healing. Traditional Chinese medicine has shown good therapeutic effects in relieving wound pain, anti-infection, promoting wound healing, reducing scar formation and enhancing immune conditioning. However, traditional Chinese medicine formulations can no longer meet the application requirements of modern clinical and battlefield environments. Therefore, it is of great significance to construct a new burn wound treatment material tha...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/38A61K31/722A61K31/7048A61K36/898A61P17/02
CPCA61K31/7048A61K31/722A61K33/38A61K36/898A61P17/02A61K2300/00
Inventor 苏永华张慧卿张丞杨葛亮苟浩韩梦飞黄若尘
Owner SHANGHAI CHANGHAI HOSPITAL
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