Nano-encapsulated retinol anti-acne gel and production method thereof
A technology of yellow aldehyde for removing acne and retinal, which can be used in pharmaceutical formulations, cosmetic preparations, dressing preparations, etc. It can solve the problems of retinal instability, strong irritation, and difficult storage, and achieve remarkable therapeutic effects , The preparation process is simple, and the effect of avoiding irritation
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Embodiment 1
[0054] A nano-encapsulated retinal liposome, which is made of the following raw materials by weight percentage: 0.5 parts by weight of retinal; 1 part by weight of vitamin C; 1 part by weight of phospholipid; 20 parts by weight of polyethylene glycol-20 10 parts by weight of caprylic triglyceride or capric triglyceride; 10 parts by weight of glycerin; 5 parts by weight of water.
[0055] The preparation method of the present embodiment comprises the following process steps:
[0056] S1. Weigh each component, add glyceryl phosphate, polyethylene glycol-20, caprylic triglyceride or capric triglyceride, and glycerin into the container, and ultrasonicate for 5 minutes until completely dissolved; heat in a water bath, and heat in a water bath The temperature is 75°C, heated for 30 minutes, and ethanol is added thereto to obtain a solution;
[0057] S2. Slowly inject the solution obtained in step S1 into retinal at a constant temperature of 50°C. The retinal is made into powder at ...
Embodiment 2
[0060] A nano-encapsulated retinal liposome, which is made of the following raw materials by weight percentage: 5 parts by weight of retinal; 3 parts by weight of vitamin C; 20 parts by weight of phospholipids; 40 parts by weight of polyethylene glycol-20 20 parts by weight of caprylic triglyceride or capric triglyceride; 30 parts by weight of glycerin; 10 parts by weight of water.
[0061] The preparation method of the present embodiment comprises the following process steps:
[0062] S1. Weigh each component, add phospholipid (phosphoglyceride), polyethylene glycol-20, caprylic triglyceride or capric triglyceride, and glycerin to the container, ultrasonicate for 7 minutes until completely dissolved; heat in a water bath , the temperature of the water bath heating is 85 ° C, heating for 40 minutes, and adding ethanol thereinto to obtain a solution;
[0063] S2. Slowly inject the solution obtained in step S1 into retinal at a constant temperature of 60°C. The retinal is made ...
Embodiment 3
[0066] A nano-encapsulated retinal liposome, which is made of the following raw materials by weight percentage: 2.5 parts by weight of retinal; 2 parts by weight of vitamin C; 10 parts by weight of phospholipid; 30 parts by weight of polyethylene glycol-20 15 parts by weight of caprylic triglyceride or capric triglyceride; 20 parts by weight of glycerin; 7 parts by weight of water.
[0067] The preparation method of the present embodiment comprises the following process steps:
[0068] S1. Weigh each component, add phospholipid (phosphoglyceride), polyethylene glycol-20, caprylic triglyceride or capric triglyceride, and glycerin to the container, ultrasonicate for 6 minutes until completely dissolved; heat in a water bath , the temperature of the water bath heating is 80 ° C, heating for 35 minutes, and adding ethanol thereinto to obtain a solution;
[0069] S2. Slowly inject the solution obtained in step S1 into retinal at a constant temperature of 55°C. The retinal is made ...
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