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Liquid crystal gel nano-particle capable of wrapping drugs with different polarities and preparation method of nano-particle

A nanoparticle and gel technology, which is applied in pharmaceutical formulations, medical preparations with inactive ingredients, and medical preparations containing active ingredients, can solve problems such as hemolysis and cytotoxicity, reduce side effects, reduce dosage, The effect of high storage stability

Active Publication Date: 2018-08-17
武汉百纳礼康生物制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, a certain concentration of unsaturated mono-fatty acid diolein can also cause hemolysis or cytotoxicity in animals.

Method used

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  • Liquid crystal gel nano-particle capable of wrapping drugs with different polarities and preparation method of nano-particle
  • Liquid crystal gel nano-particle capable of wrapping drugs with different polarities and preparation method of nano-particle
  • Liquid crystal gel nano-particle capable of wrapping drugs with different polarities and preparation method of nano-particle

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preparation example Construction

[0033] The preparation method of the liquid crystal gel nanometer of the embodiment of the present invention and comparative example, comprises the following steps:

[0034] S1. Weigh the active ingredients of the drug, glyceryl dioleate, phosphatidylcholine, phosphatidylglycerol dilaurate, and nonionic surfactant, and stir to obtain a mixed solution;

[0035] S2, adding ethanol to the mixed solution obtained in S1, and adding it together with ethanol when there are azacarbon nanotubes in the formula, and performing ultrasonic dispersion for 4 minutes to obtain a liquid crystal gel nanoparticle precursor;

[0036] S3. Add water to the liquid crystal gel nanoparticle precursor obtained in S2 to 100wt%, and then disperse it through an ultrasonic probe. The power of the ultrasonic probe is 100W, and the ultrasonic time is 9min. grain.

[0037] The samples of the embodiment of the present invention and comparative example carry out MTT cytotoxicity test in the same way, particle ...

Embodiment 1

[0043] This embodiment provides a liquid crystal gel nanoparticle, which contains the following raw materials in mass percentage: 0.2% by weight of doxorubicin, 1.5% of glyceryl dioleate, 3.0% of soybean phosphatidylcholine, and 0.6% of dilauric acid phosphatidylglycerol , polyoxyethylene 20 sorbitan monooleate 0.2%, ethanol 0.3%, and the balance is water.

[0044] figure 1 For the particle size distribution figure of the doxorubicin-loaded liquid crystal gel nanoparticles of the present invention, from figure 1 It can be clearly seen from the figure that the particle size distribution of doxorubicin-loaded liquid crystal gel nanoparticles is in the range of 60-500 nm, and the particle size distribution of the doxorubicin-loaded liquid crystal gel nanoparticles is mainly in the range of 100-200 nm. figure 2 It is a polarized light micrograph of the coarse dispersion of doxorubicin-loaded liquid crystal gel nanoparticles of the present invention, image 3 It is a micrograph ...

Embodiment 2

[0046] This embodiment provides a liquid crystal gel nanoparticle, which contains the following raw materials in mass percentage: coumarin 60.2wt%, diolein 1.5%, soybean phosphatidylcholine 3.0%, dilaurate phospholipid Acylglycerol 0.6%, polyoxyethylene 20 sorbitan monooleate 0.2%, ethanol 0.3%, and the balance is water.

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Abstract

The invention discloses a liquid crystal gel nano-particle capable of encapsulating drugs with different polarities. The liquid crystal gel nano-particle comprises, in weight percent, 0.1-0.5wt% of drug active components, 1%-3% of dilinolein, 2%-4% of phosphatidylcholine, 0.3%-1% of dilaurate phosphatidyl glycerol, 0.05%-0.5% of non-ionic surface active agents, 0.1%-1% of ethyl alcohol and the rest water, wherein an HLB (hydrophile-lipophile balance) value of the non-ionic surface active agents is 12-18. The liquid crystal gel nano-particle has high encapsulating rate for different drugs and is good in storage stability and low in cytotoxicity.

Description

technical field [0001] The invention belongs to pharmaceutical preparations, and in particular relates to a liquid crystal gel nanoparticle capable of loading drugs with different polarities and a preparation method thereof. Background technique [0002] The biological activity of the active agent is observed in many pharmaceutical products above a certain range of active agent concentration, and when the concentration in the appropriate part of the body is below the lower limit of the concentration of the active agent of the pharmaceutical active agent, the beneficial effect of these active agents will not be produced; When the concentration in the appropriate part of the body is above the upper limit of the concentration of the pharmaceutically active agent, no further increase in the concentration of the pharmaceutically active agent will produce further benefit. In some instances, increasing the concentration of a pharmaceutically active agent above a certain level can r...

Claims

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Application Information

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IPC IPC(8): A61K9/51A61K45/00A61K47/24A61K47/14
CPCA61K9/5123A61K45/00
Inventor 罗亮黄丽萍孟凡玲
Owner 武汉百纳礼康生物制药有限公司
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