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Mesoporous magnesium silicate/ hydroxyapatite/ polyether-ether-ketone composite material, bone restoration and preparation method and application thereof

A technology of hydroxyapatite and polyetheretherketone, which is applied in the field of materials, can solve the problems of looseness, poor mechanical compatibility, and inability to bond firmly to bone repair materials, and achieves accelerated bone healing, good biological activity and biological Compatibility, effect on shortening bone healing time

Inactive Publication Date: 2015-10-28
SHENZHEN KEJU NEW MATERIAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The technical problem to be solved by the present invention is to overcome the loosening and bone resorption of bone repair materials caused by stress shielding caused by the poor mechanical compatibility of existing bone repair materials, or the bone healing speed is too slow and lacks biological activity, which cannot be combined with Defects in the formation of strong bonds in bone

Method used

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  • Mesoporous magnesium silicate/ hydroxyapatite/ polyether-ether-ketone composite material, bone restoration and preparation method and application thereof
  • Mesoporous magnesium silicate/ hydroxyapatite/ polyether-ether-ketone composite material, bone restoration and preparation method and application thereof
  • Mesoporous magnesium silicate/ hydroxyapatite/ polyether-ether-ketone composite material, bone restoration and preparation method and application thereof

Examples

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Effect test

Embodiment 1

[0065] A preparation method of mesoporous magnesium silicate, comprising the steps of:

[0066] (1) Mix 8.5g of P123, 240mL of deionized water and 8g of absolute ethanol, and stir until the solution is clear, then add 20mL of hydrochloric acid with a concentration of 11.9mol / L at 40°C and stir to mix, then add 24g of TEOS Add dropwise into the solution, stir until the solution becomes white and turbid, then add 29.5g of magnesium nitrate hexahydrate, and continue stirring for 2.5h to obtain a reaction solution;

[0067] (2) Aging the reaction solution at 98°C for 48 hours, then removing the supernatant by suction filtration, drying the precipitate at 85°C, and sintering at 600°C for 7 hours to obtain mesoporous magnesium silicate.

[0068] The scanning electron micrographs and transmission electron micrographs of the mesoporous magnesium silicate / hydroxyapatite are shown in figure 1 (a), (b) and figure 1 (c), (d); the mesoporous magnesium silicate / hydroxyapatite has a mesopo...

Embodiment 2

[0070] The preparation method of mesoporous magnesium silicate / hydroxyapatite / polyether ether ketone composite material, it comprises the following steps:

[0071] Put 2kg (20wt%) of the mesoporous magnesium silicate prepared in Example 1, 1.5kg (15wt%) of hydroxyapatite and 6.5kg (65wt%) of polyether ether ketone (particle size is 10 μm) in a mixer Mix evenly to obtain a mixed powder; mix the mixed powder with absolute ethanol, disperse it ultrasonically for 30 minutes at a power of 60W, and then place it in an oven at 65°C to evaporate the absolute ethanol; product mold), and then heated up in a sintering furnace, sintered and formed, and obtained; wherein, the sintering temperature is 350 ° C; the heating rate of the sintering furnace is 1 ° C / min; the holding time is 140 min. The mechanical properties of the mesoporous magnesium silicate / hydroxyapatite / polyether ether ketone composite are shown in Table 1.

Embodiment 3

[0073] A method for preparing a bone prosthesis, comprising the steps of:

[0074] 1.5kg (15wt%) of the mesoporous magnesium silicate prepared in Example 1, 1.5kg (15wt%) of hydroxyapatite powder and 7kg (70wt%) of polyetheretherketone (particle size is 15 μm) were mixed in a mixer Mix the raw materials uniformly in the medium to obtain a mixed powder; mix the mixed powder with absolute ethanol, disperse it ultrasonically for 30 minutes with a power of 70W, and then place it in an oven at 70°C to evaporate the absolute ethanol to obtain a composite powder; then press the composite powder with a mold Molding (the mold of the bone prosthetic product), and then heating up in a sintering furnace, sintering and molding, and the obtained; wherein, the sintering temperature is 360°C; the heating rate of the sintering furnace is 1°C / min; the holding time is 140min. The mechanical properties of the bone restoration are shown in Table 1.

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Abstract

The invention discloses a mesoporous magnesium silicate / hydroxyapatite / polyether-ether-ketone composite material, a bone restoration and a preparation method and application thereof. The preparation method of the mesoporous magnesium silicate / hydroxyapatite / polyether-ether-ketone composite material comprises the steps that 15 wt%-20 wt% mesoporous magnesium silicate, 10 wt%-15 wt% hydroxyapatite and 65 wt%-75 wt% polyether-ether-ketone are uniformly mixed to obtain mixed powder; then the mixed powder is mixed with anhydrous ethanol, ultrasonic dispersion is conducted, and then the anhydrous ethanol is evaporated at the temperature ranging from 65 DEG C to 80 DEG C to obtain composite powder; a mold pressing method is adopted to conduct machining-shaping on the composite powder to obtain the composite material. The composite material is good in biological activity and biocompatibility and good in mechanical compatibility with bone tissues, and the composite material can stimulate bone growth, speed up bone healing and reduce the healing time after the material is implanted into the bone. The bone restoration has the advantages of being good in bone mechanical compatibility and antibacterial property, high in strength, good in fatigue resistance and corrosion resistance and long in service life.

Description

technical field [0001] The invention relates to the field of materials, in particular to a mesoporous magnesium silicate / hydroxyapatite / polyetheretherketone composite material and its preparation method and application, and also relates to a bone restoration and its preparation method. Background technique [0002] At present, the clinically used bone implant materials are mostly titanium-based bone implant materials and ceramic bone implant materials, but these materials have some shortcomings that are difficult to overcome. For example, the structural properties of metal materials are quite different from those of bone, and they lack active, unable to form osseointegration with bone, and easily cause bone resorption. In addition, the dissolution of metal ions may easily lead to fluid accumulation, inflammation, and necrosis; for example, ceramic bone implant materials are not easy to form and process, and have poor toughness, etc. shortcoming. Therefore, the research and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B33/22C08L71/08C08K7/26C08K3/32A61L27/46A61L27/54A61L27/50
Inventor 徐东马旭辉魏杰张珏蔡亮宋文华邬迎阳莫品书杨海灵
Owner SHENZHEN KEJU NEW MATERIAL
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