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A temperature-sensitive injectable lacrimal plug and its preparation method

A lacrimal duct suppository and injection-type technology, which can be used in pharmaceutical formulations, surgery, drug delivery, etc., can solve the problems of inconvenient implantation and removal of patients' eyes, less description of lacrimal duct suppository preparation techniques, and difficulty in popularization.

Active Publication Date: 2021-07-06
XIAN TAKOMED PHARMA TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] After decades of development, the design and preparation of foreign lacrimal plugs are relatively mature, and more international patents have been applied for. Its curative effect on dry eye disease is clear, but in the existing foreign literature and international patents, there The preparation technique is less described
At the same time, the current internationally used lacrimal plugs are mainly implantable solid lacrimal plugs, which are inconvenient to implant and take out in the eyes of patients, which brings difficulties to their popularization.

Method used

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  • A temperature-sensitive injectable lacrimal plug and its preparation method
  • A temperature-sensitive injectable lacrimal plug and its preparation method
  • A temperature-sensitive injectable lacrimal plug and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038]

[0039] Test results: The solidification temperature of the product is 31°C; in the liquid state of 15°C, the viscosity of the ingredients is about 8mPa·s measured by a viscometer; under the curing condition of 31°C, a columnar product with a diameter of 3mm and a height of 4mm is prepared, measured Obtained its extrusion strength is 15Pa. The results show that the material can basically meet the functional requirements of injectable lacrimal plugs, but the viscosity is low in liquid state and the mechanical strength is low after curing.

Embodiment 2

[0041]

[0042]

[0043] Test results: The solidification temperature of the product is 31°C; in the liquid state of 15°C, the viscosity of the ingredients is about 70mPa·s measured by a viscometer; under the curing condition of 31°C, a columnar product with a diameter of 3mm and a height of 4mm is prepared, measured Obtained its extrusion strength is 15Pa. The results show that the material can basically meet the functional requirements of injectable lacrimal plugs, but the mechanical strength is low after curing.

Embodiment 3

[0045]

[0046] Test results: The solidification temperature of the product is 31°C; in the liquid state of 15°C, the viscosity of the ingredients measured by a viscometer is about 8.1mPa·s; under the curing condition of 31°C, a columnar product with a diameter of 3mm and a height of 4mm is prepared. Its extrusion strength was measured to be 0.50 MPa. The results show that the material can basically meet the functional requirements of injectable lacrimal plug, but the viscosity is low in liquid state.

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Abstract

The invention discloses a temperature-sensitive injectable lacrimal duct suppository and a preparation method thereof. Or the lower lacrimal canaliculus opening of the animal's eye, relying on the body temperature of the human or animal to solidify the liquid injectable lacrimal duct plug to block the lower lacrimal canaliculus opening, wherein the temperature-sensitive composite hydrogel material adopts the concentration of Poloxamer 407, Polox Sharm 188 and water are formulated, and viscosity enhancers and / or strength enhancers are added as needed. The injectable lacrimal plug of the present invention has good fluidity under low temperature conditions, and can be injected into the lower lacrimal canaliculus orifice of humans or animals through a syringe, and the composite temperature-sensitive composite hydrogel can be solidified rapidly by relying on the body temperature of humans or animals. The lacrimal duct opening plays a role in relieving dry eye syndrome, and has the advantages of being simple and convenient in application, easy to operate and popularize.

Description

technical field [0001] The invention relates to a temperature-sensitive injectable lacrimal duct suppository and a preparation method thereof, belonging to the medical research field of multifunctional temperature-sensitive composite hydrogel. Background technique [0002] Dry eye syndrome refers to the abnormal tear quality or quantity caused by any reason, which leads to a decrease in the stability of the tear film, accompanied by ocular discomfort and ocular surface tissue lesions. Common symptoms include dry eyes, easy fatigue, and decreased vision. Studies have shown that dry eye syndrome is caused by insufficient secretion of lacrimal gland tears, mucin layer and oil layer, and excessive tear evaporation. The majority of patients with this symptom are the elderly and office workers who work in front of the computer for a long time. So far, there is no effective treatment for dry eye syndrome. Clinically, physiological saline, artificial tears and anti-immune eye drop...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/14A61L31/06A61L31/04
CPCA61L31/042A61L31/048A61L31/06A61L31/145A61L2400/06A61L2430/36C08L71/02C08L1/286C08L29/04C08L5/08C08L33/02C08L33/26C08L5/12C08L5/06C08L67/04
Inventor 唐永红黄赛鹏齐华锋
Owner XIAN TAKOMED PHARMA TECH
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