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Brushite bone cement preparation method

A technology of calcium phosphate rock and bone cement, which is used in medical preparations with non-active ingredients, medical preparations containing active ingredients, bone diseases, etc. Antibacterial properties, unfavorable doctor's operation and other problems, to achieve the effect of being conducive to regeneration, improving anti-collision performance, and prolonging curing time

Inactive Publication Date: 2018-07-17
袁杰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Technical problem to be solved by the present invention: Aiming at the problems that pure brushite bone cement has short curing time, poor injectability, unfavorable operation by doctors, and lack of antibacterial properties, a brushite bone cement is provided. Cement preparation method

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0023] Take 250~300g of calcium hydrogen phosphate dihydrate, 70~80g of calcium carbonate, add 500~600mL of ultrapure water, stir at 300~400r / min for 30~40min, then put it into a rotary evaporator and evaporate it to dryness under reduced pressure. The dried product is transferred to a grinder for grinding, and passed through a 200-mesh sieve to obtain raw material powder. The raw material powder is placed in a muffle furnace and calcined at 1100-1300°C for 10-12 hours. After cooling to room temperature, the calcined product is loaded into In the ball mill, use absolute ethanol as the medium, ball mill at 400~500r / min for 8~10h, filter to remove the absolute ethanol, place in a drying oven, and dry at 60~70°C for 40~50h to obtain β-tricalcium phosphate Powder, mix β-tricalcium phosphate powder and calcium dihydrogen phosphate at a molar ratio of 1:1, put it into a mortar and grind it, and pass through a 400-mesh sieve to obtain bone cement solid phase powder. Take 1~2g of lidoc...

example 2

[0025] Take 250~300g of calcium hydrogen phosphate dihydrate, 70~80g of calcium carbonate, add 500~600mL of ultrapure water, stir at 300~400r / min for 30~40min, then put it into a rotary evaporator and evaporate it to dryness under reduced pressure. The dried product is transferred to a grinder for grinding, and passed through a 200-mesh sieve to obtain raw material powder. The raw material powder is placed in a muffle furnace and calcined at 1100-1300°C for 10-12 hours. After cooling to room temperature, the calcined product is loaded into In the ball mill, use absolute ethanol as the medium, ball mill at 400~500r / min for 8~10h, filter to remove the absolute ethanol, place in a drying oven, and dry at 60~70°C for 40~50h to obtain β-tricalcium phosphate Powder, mix β-tricalcium phosphate powder and calcium dihydrogen phosphate at a molar ratio of 1:1, put it into a mortar and grind it, and pass through a 400-mesh sieve to obtain bone cement solid phase powder. Take 1~2g of lidoc...

example 3

[0027] Take 250~300g of calcium hydrogen phosphate dihydrate, 70~80g of calcium carbonate, add 500~600mL of ultrapure water, stir at 300~400r / min for 30~40min, then put it into a rotary evaporator and evaporate it to dryness under reduced pressure. The dried product is transferred to a grinder for grinding, and passed through a 200-mesh sieve to obtain raw material powder. The raw material powder is placed in a muffle furnace and calcined at 1100-1300°C for 10-12 hours. After cooling to room temperature, the calcined product is loaded into In the ball mill, use absolute ethanol as the medium, ball mill at 400~500r / min for 8~10h, filter to remove the absolute ethanol, place in a drying oven, and dry at 60~70°C for 40~50h to obtain β-tricalcium phosphate Powder, mix β-tricalcium phosphate powder and calcium dihydrogen phosphate at a molar ratio of 1:1, put it into a mortar and grind it, and pass through a 400-mesh sieve to obtain bone cement solid phase powder. Take 1~2g of lidoc...

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Abstract

The invention relates to a brushite bone cement preparation method, which belongs to the technical field of a pavement maintenance material. The method takes silk fibroin as a medical carrier, mutualentanglement is realized through a silk fibroin molecular chain, a three-dimensional network is formed, hydroxyapatite is deposited at a network skeleton, so that the scatter-resistant performance ofthe calcium phosphate bone cement is increased, silk fibroin can control medicine release through chemical bond combination and coating modes, the common medicine burst release effect is effectively controlled, during bone tissue restoration and treatment, the local medicine concentration of a treatment dosage is kept, the pharmaceutical effect of the biomaterial is prolonged, the curative effectof lidocaine for alleviating ache can be effectively performed for a long time in human body, a silk fibroin high molecular chain network is taken to provide a hydroxyapatite deposited template, through complexation effect on calcium ions, a solidification reaction is delayed, the effect for prolonging the solidification time is achieved, brushite is taken as flaky crystal, the accumulation is tight, and compressive strength is increased.

Description

technical field [0001] The invention relates to a preparation method of brushite bone cement, which belongs to the technical field of pavement maintenance materials. Background technique [0002] Bone repair materials are widely used in orthopedics, orthopedics and dentistry. There are three types according to the source, namely, autologous bone, allogeneic bone, and artificial synthetic materials. Although autologous bone is an ideal bone repair material, the source of bone donor is limited and the secondary operation brings pain to the patient. There may be morphological changes in the bone donor area. Dysfunction; Allogeneic bone has immune rejection, which may lead to infectious diseases and tumor formation. Therefore, scientists from various countries have been exploring ideal bone defect repair materials for a long time. [0003] Brushite bone cement is a type of commercially used bone graft material. It can be completely degraded in the body, has good biocompatibilit...

Claims

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Application Information

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IPC IPC(8): A61L27/12A61L27/22A61L27/20A61L27/50A61L27/54A61K31/167A61K47/42A61K47/64A61P19/08A61P29/00A61P31/04
CPCA61K31/167A61K47/42A61L27/12A61L27/20A61L27/227A61L27/50A61L27/54A61L2300/402A61L2300/404A61L2300/412A61L2300/602A61L2400/06A61L2430/02C08L5/08C08L1/284C08L89/00
Inventor 袁杰王文新李静
Owner 袁杰
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