Application of B7-H4 fusion protein in preparation of medicine used for treating systemic lupus erythematosus

Abstract

The invention discloses application of a B7-H4 fusion protein in preparation of a medicine used for treating systemic lupus erythematosus. The medicine can be injection dosage forms or oral preparations, including injection, lyophilized powder, tablets, capsules, particles and oral liquid. The provided medicine containing the B7-H4 fusion protein can effectively reduce double-stranded DNA antibodylevel in peripheral blood of a patient with the systemic lupus erythematosus, alleviate inflammatory state of lymphoid tissues of the patient and inhibit inflammatory reaction in body of the patient,also improves conditions such as renal inflammatory pathological change, proteinosis and complement deposition of the patient, and can effectively treat the systemic lupus erythematosus.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to the use of B7-H4 fusion protein in the preparation of medicines for treating systemic lupus erythematosus. Background technique [0002] Systemic lupus erythematosus is a common autoimmune disease characterized by multi-system chronic inflammatory damage to organs and tissues. Its etiology and pathogenesis are not yet fully understood. Effects, causing immune homeostasis imbalance, regulation disorder, antigen-antibody complexes, complement complex deposition in blood vessels, causing immune response and thrombosis, eventually leading to local or systemic tissue and organ damage. Generally speaking, the main cause of death of patients with systemic lupus erythematosus is organ failure and severe infection. Renal failure caused by lupus nephritis is more common in organ failure, and the incidence of lupus nephritis accounts for 50% of patients with systemic lupus erythematos...

AI Technical Summary

Problems solved by technology

These immunosuppressants can inhibit the division and proliferation of immune cells, inhibit their function, thereby exerting a strong immunosuppressive effect and non-specifically killing sensitized lymphocytes, but the side effects of immunosuppressants are very large, including gastrointestinal reactions, Hair loss, liver damage, leukopenia, etc.

Although glucocorticoids and immunosuppressants can effectively alleviate the condition of systemic lupus erythematosus, patients are still widely troubled by the toxic side effects, high recurrence rate and high mortality of the disease drugs. Lupus patients looming

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